Demographic and risk factors in patients with head and neck tumors

Abstract

The association between human papillomavirus (HPV) infection and the development of head and neck cancer has been documented recently. In this study on 86 head and neck cancer patients and 124 controls, data regarding demographics, behavioral risk factors, and risks related to HPV exposure were collected. HPV detection was carried out using polymerase chain reaction in the tumors and in oral exfoliated cells, and HPV typing by a reverse line blot assay specific for 37 HPV types. Sera were tested by an enzyme-linked immunosorbent assay specific for HPV proteins. Head and neck cancer cases report significantly more oral-anal contact (P = 0.02) and tobacco and alcohol use than controls (P = 0.001; P = 0.02, respectively). High-risk HPV DNA was detected in 43% of oral washings of cases and 4% of controls (P < 0.0001). The association between the presence of high-risk HPV DNA in oral exfoliated cells and in tumor tissues was statistically significant (adjusted P < 0.0001). The prevalence of HPV-specific antibodies was significantly higher in cases than in controls (adjusted P < 0.0001). These results provide epidemiological and immunological evidence for HR HPV as a strong risk factor (OR = 44.3, P < 0.0001) for head and neck cancer, even after controlling for age, tobacco and alcohol use. The detection of high-risk HPV DNA in oral exfoliated cells and HPV-specific antibodies in serum can be considered as clinically relevant surrogate markers for the presence of a HPV-associated head and neck cancer, with a high sensitivity (83%) and specificity (88%).

Human Papillomavirus Infection and Prognostic Predictors in Patients with Oropharyngeal Squamous Cell Carcinoma

“…Human papillomavirus has been established as an important etiologic factor in a subset of OSCC and plays a role in carcinogenesis (Gillison et al, 2000). HPV infection has been detected in 19%-75% of all oropharyngeal cancers with HPV-16 as the main subtype accounting for 85%-95% of the tumors (Gillison et al, 2000;Herrero et al, 2003;Kreimer et al, 2005;Tachezy et al, 2009St Guily et al, 2011. The HPV infection rate in our study was 16.7%, a little lower than that reported previously.…”

Prevalence of Human Papillomavirus Infection in Oral Squamous Cell Carcinoma: a Case-control Study in Wuhan, China

“…Tobacco use is proved to be an independent risk factor in this study (p=0.015). People consumed tobacco have increased risk in developing OSCC compared with non-smokers (OR=2.7, 95% CI=1.2-6.0), which is lower than other study (Tachezy et al, 2009). Alcohol consumption is also as an important risk factor for the prevalence of OSCC.…”

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“…Infection with HR_HPV has been regarded as a potential risk for the development of oral squamous cell carcinoma (OSCC). A number of studies have detected HR-HPV DNA in a considerable proportion of oral cancers with wide variations from 0% to 100% prevalence in oral tissues, perhaps reflecting the characteristic variations in different populations [10][11][12]. Oral cancer is extremely increasing in the Sudan, particularly among men [13].…”

“…Oral cancer is extremely increasing in the Sudan, particularly among men [13]. Several studies have linked the etiology of oral cancer to the oral use of Toombak (tobacco specific nitrose amine rich tobacco) [14,15] and HPV infection [4][5][6][7][8][9][10][11][12][13][14][15][16]. In Sudan the prevalence of HPV was reported to be 65% [17].…”