Prevalence of Human Papillomavirus Infection in Oral Squamous Cell Carcinoma: a Case-control Study in Wuhan, China

Gan, Lili; Zhang, Hao; Guo, Jihua; Fan, Mingwen

doi:10.7314/apjcp.2014.15.14.5861

Cited by 33 publications

(22 citation statements)

References 38 publications

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“…When analyzed for oral cavity, high-risk HPV infection was not significantly associated with oral cancer, that is in line with what is seen elsewhere Dahlstrom et al, 2003;Smith et al, 2004a,b;Pintos et al, 2008]. On the contrary, a strong relationship between high-risk HPV infection and oral cancer has been observed in other studies suggesting that HPV may be implicated in oral carcinogenesis [Gillison et al, 2000;Hansson et al, 2005;Anaya-Saavedra et al, 2008;Gan et al, 2014]. Beyond real association of high-risk HPV infection with a small fraction of oral cancer cases, it has been reported that misclassification of base of tongue cancer as oral instead of oropharyngeal cancer could result in an overestimate the association between high-risk HPV infection and oral cancer [Hobbs et al, 2006;Chaturvedi, 2012].…”

Section: Discussionsupporting

confidence: 88%

Oropharyngeal and laryngeal but not oral cancers are strongly associated with high‐risk human papillomavirus in 172 Greek patients

Tsimplaki

Argyri

Sakellaridis

et al. 2016

Journal of Medical Virology

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A strong and consistent association has been reported between human papillomavirus (HPV) infection and oropharyngeal cancer, whereas a similar link has not yet been clarified in oral and laryngeal cancer. The purpose of this study was to investigate the association between HPV infection and head and neck squamous cell carcinoma (HNSCC) in Greek patients. Cytological or tissue specimens from 172 cases patients with HNSCC and cytological specimens from 91 control subjects were analyzed for HPV DNA detection and genotyping using a microarray-based assay. Multivariate logistic regression was used to estimate odds ratios (ORs) for the association between the presence of HPV infection and HNSCC for each of the tumor site, after adjustment for potential confounders. The adjusted ORs for positivity to high-risk HPV infection for oropharyngeal and laryngeal cancer were 20.3 (95% CI: 1.7-250.1) and 22.8 (95% CI: 2.5-206.2), respectively. High-risk HPV infection was not significantly associated with oral cancer. HPV infection was independently associated with poorly differentiated tumors (OR = 2.8; 95% CI: 1.1-7.5). Our results suggest a strong association of high-risk HPV infection with oropharyngeal and laryngeal cancer. J. Med. Virol. 89:170-176, 2017. © 2016 Wiley Periodicals, Inc.

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Section: Discussionsupporting

confidence: 88%

Oropharyngeal and laryngeal but not oral cancers are strongly associated with high‐risk human papillomavirus in 172 Greek patients

Tsimplaki

Argyri

Sakellaridis

et al. 2016

Journal of Medical Virology

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“…A study conducted by Gan et al . [10] in Chinese population reported the prevalence of combined infection in the development of cancerous lesion in the oral region, due to the presence of HPV16/18 along with traditional factors (tobacco and alcohol). They found that patients with preexisting HPV infection and history of tobacco and alcohol consumption have a high risk of developing cancer in the oral region.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of human papillomavirus16 DNA and p16^INK4a protein in oral squamous cell carcinoma: A systematic review and meta-analysis

Smitha¹,

Mohan

Hemavathy

2017

J Oral Maxillofac Pathol

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Background and Aim:Indian patients with oral squamous cell carcinoma (OSCC) are etiologically associated with the use of tobacco and alcohol; yet, a proportion of tumors that may harbor human papillomavirus (HPV) infections cannot be neglected. The following meta-analysis was conducted to address the association of p16INK4a and HPV DNA with OSCC. In addition, the study also provides the updated prevalence of HPV-induced OSCC.Materials and Methods:Literature survey was performed using databases such as PubMed with the help of the following keywords – “HPV infection,” “oral squamous cell carcinoma,” “p16INK4a,” “HPV DNA,” “E6,” “E7,” “L1,” “L2” and “LCR.” Proportion method was performed to derive the forest plot using MedCalc statistical software version 16.4.3.Results:Among 145 research articles, 33 articles were selected for further analysis, in which 13 articles were related to HPV DNA detection in tissues, 11 articles detected the overexpression of p16INK4a and nine articles reported the detection of both HPV DNA and p16INK4a expression. Meta-analysis revealed significant heterogeneity (P < 0.0001) among the articles. Overall, the study consisted of 3339 patients with OSCC, among which 559 patients were diagnosed with the presence of HPV16 DNA with a random proportion of 20.1% at 95% confidence interval (CI) (13.9–27.1, P < 0.0001). Overexpression of p16INK4a protein was observed in 709 patients with a random proportion of 25.4% at 95% CI (14.3–38.3, P < 0.0001).Conclusion:HPV DNA and expression of p16INK4a was suggested as gold standard for the detection of HPV infection in many cases of cancers. Frequency of HPV infection is significantly higher in patients with OSCC as identified through the detection of HPV DNA and p16INK4a expression. Even though the association of HPV infection has been established in head and neck cancer, this review could further the establishment of molecular level interaction of HPV in patients with oral cancer.

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“…There is a wide variation in the prevalence of HPV shown in many studies worldwide. [ 6 7 8 9 10 11 ] It ranges from 15% in a study done by Benzamin et al . to 49% in another study done by Hammarstedt et al .…”

Section: Discussionmentioning

confidence: 99%

Human papillomavirus 16 and 18 in squamous cell carcinoma of oral cavity and sexual practices: A pilot study at a Tertiary Care Hospital of North India

Parshad

Nandi

Marwah

et al. 2015

Natl J Maxillofac Surg

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Context:Oral squamous cell carcinoma (OSCC) is the most common malignancy in India and tobacco and betel nut chewing are well established risk factors. Despite successful campaigns to help people shun this habit in developing countries the incidence has rather gone up and HPV and sexual practices are now definitely implicated for this.Aim:An attempt was made to generate Indian data on role of HPV and sexual practices in relation to OSCC.Settings and Design:A prospective observational study was conducted on 50 patients with oral squamous cell carcinoma.Materials and Methods:Tissue biopsies from fifty patients of oral squamous cell carcinoma (OSCC) were subjected to PCR analysis to look for presence of HPV 16 and 18. Fifty patients with benign lesions were taken as control.Statistical Methods Used:The data was statistically analysed using SPSS version 22 and chi square test.Results:42% of OSCC patients were found to harbour HPV 16 and 18 whereas only 8% of patients with benign lesions had HPV 16 and 18. A significant number of HPV positive patients i.e. 9 out of 21 gave history of multiple sexual partners and oral sex.Conclusions:This high percentage of HPV in OSCC in an Indian population from a tertiary care centre in north India and its association with prevailing sexual practices is quite significant.

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Prevalence of Human Papillomavirus Infection in Oral Squamous Cell Carcinoma: a Case-control Study in Wuhan, China

Cited by 33 publications

References 38 publications

Oropharyngeal and laryngeal but not oral cancers are strongly associated with high‐risk human papillomavirus in 172 Greek patients

Oropharyngeal and laryngeal but not oral cancers are strongly associated with high‐risk human papillomavirus in 172 Greek patients

Prevalence of human papillomavirus16 DNA and p16^INK4a protein in oral squamous cell carcinoma: A systematic review and meta-analysis

Human papillomavirus 16 and 18 in squamous cell carcinoma of oral cavity and sexual practices: A pilot study at a Tertiary Care Hospital of North India

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Prevalence of Human Papillomavirus Infection in Oral Squamous Cell Carcinoma: a Case-control Study in Wuhan, China

Cited by 33 publications

References 38 publications

Oropharyngeal and laryngeal but not oral cancers are strongly associated with high‐risk human papillomavirus in 172 Greek patients

Oropharyngeal and laryngeal but not oral cancers are strongly associated with high‐risk human papillomavirus in 172 Greek patients

Prevalence of human papillomavirus16 DNA and p16INK4a protein in oral squamous cell carcinoma: A systematic review and meta-analysis

Human papillomavirus 16 and 18 in squamous cell carcinoma of oral cavity and sexual practices: A pilot study at a Tertiary Care Hospital of North India

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Prevalence of human papillomavirus16 DNA and p16^INK4a protein in oral squamous cell carcinoma: A systematic review and meta-analysis