Human Papillomavirus Infection and Prognostic Predictors in Patients with Oropharyngeal Squamous Cell Carcinoma

Huang, Hui Qiang; Zhang, Bin; Chen, Wen; Zhou, Shuang-mei; Zhang, Yongxia; Gao, Li; Xu, Zhengang; Qiao, You‐Lin; Tang, Ping-zhang

doi:10.7314/apjcp.2012.13.3.891

Cited by 35 publications

(32 citation statements)

References 28 publications

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“…Supporting this hypothesis, two large studies both conducted in >5,000 individuals from United States [17] and China [19], reported an overall prevalence of oral HPV infection of 6.8% and 0.6%, respectively. Of interest, these data reflect the rates of HPV-positive OPSCC in these different areas [42,43]. The percentage of HPV-driven OPSCC has been reported to be low in Northeast Italy [10].…”

Section: Discussionmentioning

confidence: 91%

Prevalence and Determinants of Oral Human Papillomavirus Infection in 500 Young Adults from Italy

et al. 2017

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Although the prevalence of human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC) is increasing in developed countries and becoming a relevant health issue, the natural history of oral HPV infection is still unclear. Estimating the infection’s prevalence in specific populations and identifying risk factors can widen our understanding of its natural history and help to delineate appropriate prevention strategies. This study sought to (i) determine oral HPV prevalence and genotype distribution in a large series of young Italian adults, (ii) validate an oral rinse sampling/storage protocol, and (iii) pinpoint factors associated with oral HPV infection. Five hundred students, nurses, and technicians (19–35 years-old) studying and working at/for the University of Padua were recruited. Each participant was provided with an oral rinse sampling kit and instructions for use. They were also asked to complete an anonymous questionnaire concerning their demographic characteristics and behaviors. The questionnaires and oral rinse containers were labeled with the same identification code number. The oral rinse samples were tested using a bead-based multiplex BSGP5+/6+-MPG genotyping assay which amplifies the L1 region of 51 mucosal HPV types. The prevalence of oral HPV infection was 4.0% (95% confidence interval (CI), 2.5%-6.1%); those of 14 high-risk HPV types and of HPV-type 16 (HPV16) infection were 2.2% (95% CI, 1.1%-3.9%) and 1.6% (95% CI, 0.6%-3.1%), respectively. HPV16 was the most frequent genotype (40.0% of oral HPV infections). No association was found between oral infection and the co-variables studied (gender, tobacco, alcohol and illegal drug use, number of sex and oral sex partners, HPV vaccination status, history of HPV and sexually transmitted infections, abnormal pap smears, recurrent tonsillitis and tonsillectomy). The oral rinse sampling protocol outlined here proved to be simple, efficient and well tolerated, and the prevalence rate can be considered reliable and thus useful to guide future research. Determinants of oral HPV infection are still unclear and further studies are certainly warranted.

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Section: Discussionmentioning

confidence: 91%

Prevalence and Determinants of Oral Human Papillomavirus Infection in 500 Young Adults from Italy

et al. 2017

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“…HPV causes cervical cancer (Harald, 2002) and is a factor that predicts better prognosis of patients with oropharyngeal cancer (Gillison, 2000;D'Souza, 2007;Fakhry, 2008;Ang, 2010;Chaturvedi, 2011;Huang et al, 2012). HPV positive oropharyngeal cancers are increasing in Turkish patients as in the Western world (Tural et al, 2013).…”

mentioning

confidence: 99%

Lack of Association between High-risk Human Papillomaviruses and Oral Squamous Cell Carcinoma in Young Japanese Patients

Rushatamukayanunt

Morita²,

Matsukawa³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…In China, although there lacks systematic analysis of the incidence trend of HPVpositive OSCC, HPV infection was recently detected in 17% of OSCCs from China (5), close to 18% to 36% in most studies from developed countries (6)(7)(8). Compared with OSCC caused by smoking and drinking, HPVpositive OSCC represents a distinct molecular and clinicopathologic disease entity with a favorable prognosis (3,5,9).…”

Section: Introductionmentioning

confidence: 99%

Oral Human Papillomavirus Infection and Its Risk Factors among 5,410 Healthy Adults in China, 2009–2011

Hang

Liu

et al. 2014

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Despite the established link between oral human papillomavirus (HPV) infection and a subset of oropharyngeal squamous cell carcinoma (OSCC), little is known about the epidemiology of oral HPV infection among healthy adults in China.Methods: Oral swab specimens and questionnaires were collected from 5,410 individuals (ages 25-65 years). HPV DNA in oral exfoliated cells was tested by general primer-mediated (SPF1/GP6þ) PCR and sequencing. Univariate and multivariate analyses were performed to assess the associations between exposure factors and oral infection.Results: Alpha mucosal HPV types were detected in 0.67% [95% confidence interval (CI), 0.47%-0.93%] of 5,351 b-globin-positive specimens, and cutaneous HPV in 5.46% (95% CI, 4.86%-6.10%). HPV 16 and 3 were the most prevalent types of a mucosal (0.43%; 95% CI, 0.27%-0.64%) and cutaneous HPV (4.17%; 95% CI, 3.65%-4.74%), respectively. The prevalence of a mucosal HPV decreased with increasing age (25-65 years) from 0.93% to 0.36% (P trend ¼ 0.033), and was associated with self-reported history of oral disease [adjusted odds ratio (OR), 4.78; 95% CI, 1.07-21.41]. In 1,614 heterosexual couples, cutaneous HPV in one partner was found to increase the other partner's risk of cutaneous HPV infection (adjusted OR, 2.33; 95% CI, 1.22-4.48).Conclusions: Oral HPV infection, particularly with a mucosal types, is rare among healthy adults in China. A younger age and a history of oral disease imply higher risk of a mucosal HPV infection.

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Human Papillomavirus Infection and Prognostic Predictors in Patients with Oropharyngeal Squamous Cell Carcinoma

Cited by 35 publications

References 28 publications

Prevalence and Determinants of Oral Human Papillomavirus Infection in 500 Young Adults from Italy

Prevalence and Determinants of Oral Human Papillomavirus Infection in 500 Young Adults from Italy

Lack of Association between High-risk Human Papillomaviruses and Oral Squamous Cell Carcinoma in Young Japanese Patients

Oral Human Papillomavirus Infection and Its Risk Factors among 5,410 Healthy Adults in China, 2009–2011

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