Deltamethrin induced oxidative stress in kidney and brain of rats: Protective effect of Artemisia campestris essential oil

Saoudi, Mongi; Badraoui, Riadh; Bouhajja, Houda; Ncir, Marwa; Rahmouni, Fatma; Grati, Malek; Jamoussi, Kamel; Feki, Abdelfattah El

doi:10.1016/j.biopha.2017.08.030

Cited by 51 publications

(25 citation statements)

References 40 publications

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“…28,29 Malondialdehyde, an endproduct of LPO and oxidative stress, was shown to increase after 48 hours of DEL administration. [30][31][32] However, in our study, MDA level has not changed upon the 24 hours administration of DEL alone and its combination with other insect repellants. In view of the above results, it could be stated that 24 hours exposure to DEL alone and its combination with other insect repellents were not able to induce significant LPO.…”

Section: Discussioncontrasting

confidence: 69%

“…DEL induces lipid peroxidation (LPO) subsequently free radical generation and diminishes the intracellular antioxidant enzymes which cause nephrotoxicity and hepatotoxicity . Malondialdehyde, an end‐product of LPO and oxidative stress, was shown to increase after 48 hours of DEL administration . However, in our study, MDA level has not changed upon the 24 hours administration of DEL alone and its combination with other insect repellants.…”

Section: Discussioncontrasting

confidence: 64%

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Oxidative stress and neuromodulatory effects of deltamethrin and its combination with insect repellents in rats

Magesh

Anitha

Vijayaraghavan

et al. 2019

Environmental Toxicology

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Deltamethrin (DEL) and other synthetic repellents like N,N‐diethyl benzamide (DEB), N,N‐diethyl phenylacetamide (DEPA), and N,N‐diethyl meta toluamide (DEET) are widely used due their high efficacy against mosquitoes. We evaluated the safe dose on exposure to insecticide and insect repellent individually and in combination in Wistar rats. Rats were administrated with individual chemicals DEL, DEB, DEPA, and DEET and in combination of DEL along DEB, DEPA, and DEET. The reduced glutathione and its detoxifying enzymes were significantly increased in DEL treated rats. Serotonin, dopamine, and noradrenaline were increased in DEL alone and its combination groups. Histopathology revealed that DEL and along with other insect repellants can cause lung toxicities. This study suggests that DEL in combination with other insect repellents showed antagonistic effect against oxidative stress, and there was no significant toxicological effect in the combination groups. The insect repellents with DEL cause less toxic effect and is safe for use.

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Section: Discussioncontrasting

confidence: 69%

Section: Discussioncontrasting

confidence: 64%

Oxidative stress and neuromodulatory effects of deltamethrin and its combination with insect repellents in rats

Magesh

Anitha

Vijayaraghavan

et al. 2019

Environmental Toxicology

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“…Numerous investigations have indicated that it increases the risk of neurodegenerative diseases (51-54), as it inhibits nerve impulse by altering voltage-sensitive sodium channel kinetics and ligand-gated ion channels (GABA receptors, nicotinic acetylcholine receptors, and glutamate receptors) (14,54). Its toxicity in the brain has been demonstrated in rats through the inhibition of acetylcholinesterase (AChE) activity (16,17). Probably due to its lipophilic nature, deltamethrin inhibits AChE activity by reducing the acetylcholine binding space at the aromatic, hydrophobic surface of AChE (17,55).…”

Section: Pyrethroidsmentioning

confidence: 99%

“…On the other arm of the oxidation balance, deltamethrin was reported to substantially decrease antioxidative activities of SOD, CAT, and GPx, and GSH in rat brain tissue (16,17,27). Similar effect on antioxidant enzymes was reported for cypermethrin (80 mg/kg, single dose) (79).…”

Section: Pyrethroidsmentioning

confidence: 99%

Pyrethroid exposure and neurotoxicity: a mechanistic approach

Mohammadi

Ghassemi-Barghi

Malakshah

et al. 2019

Archives of Industrial Hygiene and Toxicology

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Pyrethroids are a class of synthetic insecticides that are used widely in and around households to control the pest. Concerns about exposure to this group of pesticides are now mainly related to their neurotoxicity and nigrostriatal dopaminergic neurodegeneration seen in Parkinson’s disease. The main neurotoxic mechanisms include oxidative stress, inflammation, neuronal cell loss, and mitochondrial dysfunction. The main neurodegeneration targets are ion channels. However, other receptors, enzymes, and several signalling pathways can also participate in disorders induced by pyrethroids. The aim of this review is to elucidate the main mechanisms involved in neurotoxicity caused by pyrethroids deltamethrin, permethrin, and cypermethrin. We also review common targets and pathways of Parkinson’s disease therapy, including Nrf2, Nurr1, and PPARγ, and how they are affected by exposure to pyrethroids. We conclude with possibilities to be addressed by future research of novel methods of protection against neurological disorders caused by pesticides that may also find their use in the management/treatment of Parkinson’s disease.

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“…In this study, co-exposure to As and DM resulted in the inhibition of all the antioxidant enzyme activities measured except in the testis, where the toxicants caused an increase in CAT activity. Inhibition of antioxidant enzyme activity has been reported following exposure of animals to either As or DM [33][34][35][36]. The observed decrease in SOD, CAT and GPx activities may be due to oxidative inactivation of the proteins arising through the damaging effect of free radicals generated by both As and DM.…”

Section: Discussionmentioning

confidence: 99%

Catechin Attenuates the Effect of Combined Arsenic and Deltamethrin Toxicity by Abrogation of Oxidative Stress and Inflammation in Wistar Rats

Kayode¹,

Arinola²,

Adesola³

et al. 2019

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This study was aimed at evaluating the protective role of catechin (CT) against toxicity induced by combined exposure to arsenic (As) and deltamethrin (DM) in rats. Thirty-five (35) male Wistar rats were divided into 5 groups of 7 animals each. Treatment of each group was as follows: Control (C) administered corn oil (1ml kg -1 ), catechin only (CT) at 40mg kg -1 , As+DM administered As (100ppm) in their drinking water and DM at a dose of 7.5mg kg -1 (1/20 th LD 50 ), As+DM-CT 40 treated as As+DM in addition to oral administration of CT at 40mg kg -1 while the last group, As+DM-CT 80 received the same treatment as As+DM, along with oral CT treatment at a dose of 80mg kg -1 . The treatment lasted for 28 days. Effect of the treatment in inducing oxidative damage was appraised by estimating levels of lipid peroxidation, protein oxidation, glutathione and total antioxidant capacity in the liver, kidney, and testis of the rats. Also, the activities of superoxide dismutase, catalase, and glutathione peroxidase were assayed in the tissues. For the evaluation of inflammation, plasma levels of interleukin-6, tumor necrosis factor-alpha and 8-nitroguanine were determined. The result showed that the combination of As and DM gave rise to marked alterations of these parameters but supplementation with CT attenuated these effects.

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Deltamethrin induced oxidative stress in kidney and brain of rats: Protective effect of Artemisia campestris essential oil

Cited by 51 publications

References 40 publications

Oxidative stress and neuromodulatory effects of deltamethrin and its combination with insect repellents in rats

Oxidative stress and neuromodulatory effects of deltamethrin and its combination with insect repellents in rats

Pyrethroid exposure and neurotoxicity: a mechanistic approach

Catechin Attenuates the Effect of Combined Arsenic and Deltamethrin Toxicity by Abrogation of Oxidative Stress and Inflammation in Wistar Rats

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