Delivery Systems Made of Natural‐Origin Polymers for Tissue Engineering and Regenerative Medicine Applications

Martins, Albino; Ferreira, Helena; Reis, Rui L.; Neves, Nuno M.

doi:10.1002/9781119126218.ch31

Cited by 5 publications

(4 citation statements)

References 144 publications

(183 reference statements)

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“…On-demand release kinetics optimize drug specificity, quantity, and reduce drug toxicity. The physiological environment including active enzymes and pH, or external stimuli like temperature, physical fields, light, or ultrasound ( Figure 10), are feasible triggers in designed drug delivery systems [12,35,[205][206][207][208][209][210][211][212][213][214][215].…”

Section: Triggered Drug Deliverymentioning

confidence: 99%

Adjuvant Drug-Assisted Bone Healing: Advances and Challenges in Drug Delivery Approaches

et al. 2020

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Bone defects of critical size after compound fractures, infections, or tumor resections are a challenge in treatment. Particularly, this applies to bone defects in patients with impaired bone healing due to frequently occurring metabolic diseases (above all diabetes mellitus and osteoporosis), chronic inflammation, and cancer. Adjuvant therapeutic agents such as recombinant growth factors, lipid mediators, antibiotics, antiphlogistics, and proangiogenics as well as other promising anti-resorptive and anabolic molecules contribute to improving bone healing in these disorders, especially when they are released in a targeted and controlled manner during crucial bone healing phases. In this regard, the development of smart biocompatible and biostable polymers such as implant coatings, scaffolds, or particle-based materials for drug release is crucial. Innovative chemical, physico- and biochemical approaches for controlled tailor-made degradation or the stimulus-responsive release of substances from these materials, and more, are advantageous. In this review, we discuss current developments, progress, but also pitfalls and setbacks of such approaches in supporting or controlling bone healing. The focus is on the critical evaluation of recent preclinical studies investigating different carrier systems, dual- or co-delivery systems as well as triggered- or targeted delivery systems for release of a panoply of drugs.

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Section: Triggered Drug Deliverymentioning

confidence: 99%

Adjuvant Drug-Assisted Bone Healing: Advances and Challenges in Drug Delivery Approaches

et al. 2020

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“…size and degradation rate in the biological environment) will also influence the release of the drugs [25]. Efforts were also made to achieve a drug release in a pulsatile fashion, triggered by changes in the neighboring milieu (self-regulated delivery systems using different mechanisms, such as pH-sensitive polymers, enzymes, illness markers and pH-dependent drug solubility) or by an external stimulus (externally triggered systems by a magnetic, thermal, ultrasonic, electric or irradiation stimulus) [26][27][28]. Among the wide variety of natural, semisynthetic or synthetic materials that can be used to produce DDS, biodegradable polymers (e.g.…”

Section: Article Highlightsmentioning

confidence: 99%

Biodegradable polymers: an update on drug delivery in bone and cartilage diseases

Lima

Ferreira

Reis

et al. 2019

Expert Opinion on Drug Delivery

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Introduction: The unique structure of bone and cartilage makes the systemic delivery of free drugs to those connective tissues very challenging. Consequently, effective and targeted delivery for bone and cartilage is of utmost importance. Engineered biodegradable polymers enable designing carriers for a targeted and temporal controlled release of one or more drugs in concentrations within the therapeutic range. Also, tissue engineering strategies can allow drug delivery to advantageously promote the in situ tissue repair. Areas covered: This review article highlights various drug delivery systems (DDS) based on biodegradable biomaterials to treat bone and/or cartilage diseases. We will review their applications in osteoporosis, inflammatory arthritis (namely osteoarthritis and rheumatoid arthritis), cancer and bone and cartilage tissue engineering. Expert opinion: The increased knowledge about biomaterials science and of the pathophysiology of diseases, biomarkers, and targets as well as the development of innovative tools has led to the design of high value-added DDS. However, some challenges persist and are mainly related to an appropriate residence time and a controlled and sustained release over a prolonged period of time of the therapeutic agents. Additionally, the poor prediction value of some preclinical animal models hinders the translation of many formulations into the clinical practice.

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“…All these factors can lead to regulatory issues for commercial approval. 57 The advantages and disadvantages of the protein discussed in the present article are summarized in Table 2.…”

Section: Advantages and Disadvantages Of Protein Nanoparticlesmentioning

confidence: 99%

Protein: a versatile biopolymer for the fabrication of smart materials for drug delivery

2019

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Drug delivery is a broad field which deals with the delivery of pharmaceutical compounds to the desired site with an aim to achieve maximum therapeutic effect and minimum toxicity in treating a diseased condition. To achieve the goal, a carrier system is required for controlled and sustained drug release. Polymers are an all-time favourite matrix used to control the release of drug at the desired rate. Among the polymers, the biopolymers derived from proteins are attracting considerable attention due to their utility in delivering vaccine and chemotherapeutics in clinical application. Additionally, they are biocompatible, biodegradable, and in certain cases, cost-effective. The review addresses the source, structure and characterization of different proteins used as drug delivery carriers. Along with this, the factors contributing to the release of drug from the protein carrier has also been discussed.

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Delivery Systems Made of Natural‐Origin Polymers for Tissue Engineering and Regenerative Medicine Applications

Abstract: DELIVERY SYSTEMS MADE OF NATURAL-ORIGIN POLYMERS entrapped material against degradation by, for example, light or enzymes, incorpora-Au: We have abridged the running head due to space constraint. Could you please confirm that it is OK?

Cited by 5 publications

References 144 publications

Adjuvant Drug-Assisted Bone Healing: Advances and Challenges in Drug Delivery Approaches

Adjuvant Drug-Assisted Bone Healing: Advances and Challenges in Drug Delivery Approaches

Biodegradable polymers: an update on drug delivery in bone and cartilage diseases

Protein: a versatile biopolymer for the fabrication of smart materials for drug delivery

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