Adjuvant Drug-Assisted Bone Healing: Advances and Challenges in Drug Delivery Approaches

Rothe, R; Hauser, Sandra; Neuber, Christin; Laube, Markus; Schulze, Sabine; Rammelt, Stefan; Pietzsch, Jens

doi:10.3390/pharmaceutics12050428

Cited by 30 publications

(26 citation statements)

References 236 publications

(283 reference statements)

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“…Furthermore, several attempts have been undertaken to specifically target BMPs, PTH or OPG in order to improve bone integrity [ 256 ]. Finally, biocompatible polymers may provide novel strategies to enhance bone healing in patients with metastatic bone cancers [ 257 ].…”

Section: Diagnosis and Therapy Of Bone Metastasesmentioning

confidence: 99%

Mechanisms, Diagnosis and Treatment of Bone Metastases

Ban

Fock

Aryee

et al. 2021

Cells

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Bone and bone marrow are among the most frequent metastatic sites of cancer. The occurrence of bone metastasis is frequently associated with a dismal disease outcome. The prevention and therapy of bone metastases is a priority in the treatment of cancer patients. However, current therapeutic options for patients with bone metastatic disease are limited in efficacy and associated with increased morbidity. Therefore, most current therapies are mainly palliative in nature. A better understanding of the underlying molecular pathways of the bone metastatic process is warranted to develop novel, well-tolerated and more successful treatments for a significant improvement of patients’ quality of life and disease outcome. In this review, we provide comparative mechanistic insights into the bone metastatic process of various solid tumors, including pediatric cancers. We also highlight current and innovative approaches to biologically targeted therapy and immunotherapy. In particular, we discuss the role of the bone marrow microenvironment in the attraction, homing, dormancy and outgrowth of metastatic tumor cells and the ensuing therapeutic implications. Multiple signaling pathways have been described to contribute to metastatic spread to the bone of specific cancer entities, with most knowledge derived from the study of breast and prostate cancer. However, it is likely that similar mechanisms are involved in different types of cancer, including multiple myeloma, primary bone sarcomas and neuroblastoma. The metastatic rate-limiting interaction of tumor cells with the various cellular and noncellular components of the bone-marrow niche provides attractive therapeutic targets, which are already partially exploited by novel promising immunotherapies.

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Section: Diagnosis and Therapy Of Bone Metastasesmentioning

confidence: 99%

Mechanisms, Diagnosis and Treatment of Bone Metastases

Ban

Fock

Aryee

et al. 2021

Cells

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“…In the previous sections, it was also shown that different drugs and drug concentrations, respectively, are particularly beneficial, depending on the stage of tissue regeneration. Thus, release materials possessing multiple release mechanisms or materials that release the active ingredient in response to a certain stimulus are the focus of recent research [456][457][458][459][460][461].…”

Section: Drug Release Concepts Mechanisms and Applications In Stem Cell-based Osteogenesis And Angiogenesismentioning

confidence: 99%

Sinking Our Teeth in Getting Dental Stem Cells to Clinics for Bone Regeneration

Shoushrah

Transfeld

Tonk

et al. 2021

IJMS

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Dental stem cells have been isolated from the medical waste of various dental tissues. They have been characterized by numerous markers, which are evaluated herein and differentiated into multiple cell types. They can also be used to generate cell lines and iPSCs for long-term in vitro research. Methods for utilizing these stem cells including cellular systems such as organoids or cell sheets, cell-free systems such as exosomes, and scaffold-based approaches with and without drug release concepts are reported in this review and presented with new pictures for clarification. These in vitro applications can be deployed in disease modeling and subsequent pharmaceutical research and also pave the way for tissue regeneration. The main focus herein is on the potential of dental stem cells for hard tissue regeneration, especially bone, by evaluating their potential for osteogenesis and angiogenesis, and the regulation of these two processes by growth factors and environmental stimulators. Current in vitro and in vivo publications show numerous benefits of using dental stem cells for research purposes and hard tissue regeneration. However, only a few clinical trials currently exist. The goal of this review is to pinpoint this imbalance and encourage scientists to pick up this research and proceed one step further to translation.

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“…Refinements in surgical procedures, implant construction and postoperative care have greatly increased patient outcomes for complex injuries and abnormalities caused by high energy trauma, cancer, developmental deformity and surgery. [101][102][103][104][105] Extensive soft tissue damage, inadequate surgical techniques, infections, and biomechanical instability can lead to large defects with limited internal regenerative potential. These defects represent a significant surgical challenge, associated with high socio-economic costs and have a high impact on the quality of life of patients.…”

Section: Translation Of Bone Engineering Concept From Bench To Bedsidementioning

confidence: 99%

Materials science and design principles of therapeutic materials in orthopedic and bone tissue engineering

Liang

Dong

Shen

et al. 2021

Polymers for Advanced Techs

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The successful materials design for bone-tissue engineering needs to understand the structure and composition of host bone tissue, and selecting appropriate biomimetic natural or tunable synthetic materials (biomaterials), such as polymers, bioceramics, metals, and composites. Materials that improve bone tissue engineering have tremendous potential for clinical applications to treat and regenerate various bone injuries and fractures. The drive to design bone grafts for bridging the gaps in orthopedic tissue regeneration results in a significant research thrust for designing and developing material for bone tissue regeneration. Recently, numerous challenges, including biomaterial designing, can well suit the biological, chemical and mechanical microenvironment of natural orthopedic tissues and adopt vascularization. Novel bio-inspired materials attempt to enhance the biofunctionality that reconstruct microlevel biofactor and topographical signals from the extracellular environment are rapidly developing. The most important paradigm shift in orthopedic tissue engineering is the careful selection of scaffold, signals, and cell types to design biomaterials. Notwithstanding, the clinical outcome of orthopedic tissue regeneration was so vibrant years ago; however, so far, it failed to achieve the expected results and failed to translate in the clinical setting. In the current review, we discuss the aims and mechanism of bone tissue regeneration, biomaterial designing, and orthopedic tissue engineering requirements. Next, we highlight the principle for orthopedic tissue engineering and describe the strategies for enhancing material Bio-functionality. Finally, we give the bench to bedside concept and concluding remarks with a special focus on future. The main purpose of current paper is to give a comprehensive overview, which is helpful for the researcher to distill this information and design future research strategies for designing materials for orthopedic and bone tissue engineering.

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Adjuvant Drug-Assisted Bone Healing: Advances and Challenges in Drug Delivery Approaches

Cited by 30 publications

References 236 publications

Mechanisms, Diagnosis and Treatment of Bone Metastases

Mechanisms, Diagnosis and Treatment of Bone Metastases

Sinking Our Teeth in Getting Dental Stem Cells to Clinics for Bone Regeneration

Materials science and design principles of therapeutic materials in orthopedic and bone tissue engineering

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