Adzope's Municipal Artificial Lake which serves as a drinking water supply to the population is prone to pollution due to human activities and increasing urbanization. Thus, it is essential to protect this surface water supply for sustainable use. The objective of this study is to determine the protection zones around this water reservoir in order to preserve the stored water quality. To achieve this, a methodological approach based on a Geographic Information System (GIS) was adopted. This methodological approach first consisted to assess the water reservoir vulnerability to pollution according to certain hydrological parameters (slope, land use, soil type, runoff, and drainage network density) and then to determine the protection zones according to the different vulnerability classes. After the scoring of different parameters, a weight was assigned to each, from the multi-criteria method (AHP). The combination of the weighted parameters in the GIS enabled to establish the water reservoir vulnerability indexes map. The vulnerability map established subsequently presents five (5) vulnerability classes in the watershed: very low (12%) and low (23%) in the North and South of the study area, moderate (32%) disseminated throughout the study area, high (20%) and very high (13%) particularly in the West and North of the water reservoir and in the East of study area. This water reservoir vulnerability map is potentially influenced by the land use parameter according to the sensitivity analysis test. The different vulnerability classes then allowed the delimitation of three protection zones (Zone 1, Zone 2 and Zone 3) around the water reservoir. The immediate protection zone (Zone 1) has a width between 100 and 450 m around the water reservoir with *Geographic Information System for protection zones delineation around a surface water resource.