Deleterious effects of potassium bromate administration on renal and hepatic tissues of Swiss mice

Abstract

Potassium bromate (KBrO) is widely used as a food additive and is a major water disinfection by-product. The present study reports the side effects of KBrO administration in Swiss mice. Animals were randomly divided into three groups: control, low dose KBrO (100 mg/kg/day) and high dose KBrO (200 mg/kg/day) groups. Administration of KBrO led to decreased white blood corpuscles (WBCs), red blood corpuscles (RBCs) and platelets count in the animals of both the high and the low dose groups. Altered lipid profile represented as low density lipoprotein (LDL), high density lipoprotein (HDL) and cholesterol levels were observed in plasma samples of both KBrO treated groups of mice. Also, an increased plasma level of LDH was detected in both KBrO treated groups. Histological investigations showed impaired renal and hepatic histology that was concomitant with increased plasma Creatinine level in both of KBrO-treated groups. Nevertheless, decreased glutathione (GSH) level in both renal and hepatic tissue of mice after KBrO intake was detected. These results show that KBrO has serious damaging effects and therefore, its use should be avoided.

Deleterious effects of perinatal exposure to potassium bromate on the development of offspring of Swiss mice

“…Owing to its hazardous potential, the use of KBrO 3 has been banned in several countries (Oloyede and Sunmonu, 2009). The adverse side effects of KBrO 3 include hematological alterations and altered histomorphology and normal functioning of liver and kidney (Altoom et al, 2018). Several studies have demonstrated reduced body weight gain, suppressed locomotor activities, and ataxia in adult mice following bromate ingestion (Ajarem et al, 2016; Altoom et al, 2018; Kurokawa et al, 1990).…”

“…Appearance of the vaginal plug was considered the first day of gestation. Pregnant mice were randomly divided into two groups each comprising 10 mothers as follows: Control group (Control): Pregnant mice received 1 ml drinking water daily by oral intubation from gestational day (D) 5 to postnatal D21. Bromate-exposed group (KBrO 3 ): Pregnant mice received a daily oral dose of KBrO 3 (200 mg/kg body weight; Altoom et al, 2018; Kurokawa et al, 1990) dissolved in bottled drinking water by oral intubation from gestational D5 to postnatal D21. …”

“…Bromate-exposed group (KBrO 3 ): Pregnant mice received a daily oral dose of KBrO 3 (200 mg/kg body weight; Altoom et al, 2018; Kurokawa et al, 1990) dissolved in bottled drinking water by oral intubation from gestational D5 to postnatal D21.…”

Propolis prevents inhibition of apoptosis by potassium bromate in CCD 841 human colon cell

“…Potassium bromate (KBrO 3 ) has been known as a mutagen agent inducing carcinogenesis, and humans might be exposed to potassium bromate either through drinking water (as a byproduct of ozonisation) or bakery products (as a food additive) . It has been shown that potassium bromate induces oxidative stress and DNA damage in cell culture and inhibits apoptotic pathways in experimental animal studies . In this study, we aimed to investigate possible cancer‐induced effect of potassium bromate in normal colon cell line by determining the molecules in apoptosis pathways.…”

The Alleviative Effect of Vitamin B2 on Potassium Bromate-Induced Hepatotoxicity in Male Rats

“…Its traces can be cited in multiple packaged and municipality supply water after ozonization during the filtration process [ 1 ]. Also, it is used in improving flour quality and dough conditioning in the baking industry as well as in the preparation of beverages, cheese, and fish paste [ 2 – 4 ]. Hence, PB in various consumer items poses mild to severe toxicity to critical organs, viz., the kidney, liver, and brain in the living systems [ 5 – 7 ].…”