Deleterious effects of perinatal exposure to potassium bromate on the development of offspring of Swiss mice

Abstract

The present study aimed to investigate the impact of perinatal potassium bromate (KBrO 3) exposure on the development of sensorimotor reflexes and redox status, and on the histological architecture of the brain, liver, and kidney of newborn mice. Pregnant mice received 1-ml bottled drinking water daily by oral intubation and served as the control group. Another group of pregnant mice were supplemented orally with 200 mg/kg body weight KBrO 3 dissolved in drinking water from gestation day 5 to postnatal day 21. KBrO 3 induced a decrease in the postnatal body weight in the newborn mice. KBrO 3-exposed newborn mice showed poor performance and delayed development of the sensorimotor reflexes. Histological changes, increased lipid peroxidation, and altered antioxidants were reported in the cerebrum, cerebellum, medulla oblongata, liver, and kidney of the KBrO 3exposed newborn mice. In conclusion, these findings demonstrated that perinatal exposure to bromate induced oxidative stress, histological and behavioral alterations, and was a potential teratogen in newborn mice.

Lycopene reduces potassium bromate-induced structural alterations in the jejunal mucosa of adult rats

“…Previous studies have reported the serious destructive effect of KBrO 3 on different organs such as the kidney [3] , liver [4] , thyroid gland [5] , and the central nervous system [6] . Oxidative DNA damage was also reported as one of the serious effects of bromate [7] and therefore it was considered as a potential carcinogen in both humans and animals [8] and was banned from use in manufactured goods in several countries [9] .…”