BackgroundPotassium bromate (KBrO3) is widely used as a food additive and is a major water disinfection by-product. The present study reports the side effects of KBrO3 administration on the brain functions and behaviour of albino mice.MethodsAnimals were divided into three groups: control, low dose KBrO3 (100 mg/kg/day) and high dose KBrO3 (200 mg/kg/day) groups.ResultsAdministration of KBrO3 led to a significant change in the body weight in the animals of the high dose group in the first, second and the last weeks while water consumption was not significantly changed. Neurobehavioral changes and a reduced Neurotransmitters levels were observed in both KBrO3 groups of mice. Also, the brain level of reduced glutathione (GSH) in KBrO3 receiving animals was decreased. Histological studies favoured these biochemical results showing extensive damage in the histological sections of brain of KBrO3-treated animals.ConclusionsThese results show that KBrO3 has serious damaging effects on the central nervous system and therefore, its use should be avoided.
Potassium bromate (KBrO) is widely used as a food additive and is a major water disinfection by-product. The present study reports the side effects of KBrO administration in Swiss mice. Animals were randomly divided into three groups: control, low dose KBrO (100 mg/kg/day) and high dose KBrO (200 mg/kg/day) groups. Administration of KBrO led to decreased white blood corpuscles (WBCs), red blood corpuscles (RBCs) and platelets count in the animals of both the high and the low dose groups. Altered lipid profile represented as low density lipoprotein (LDL), high density lipoprotein (HDL) and cholesterol levels were observed in plasma samples of both KBrO treated groups of mice. Also, an increased plasma level of LDH was detected in both KBrO treated groups. Histological investigations showed impaired renal and hepatic histology that was concomitant with increased plasma Creatinine level in both of KBrO-treated groups. Nevertheless, decreased glutathione (GSH) level in both renal and hepatic tissue of mice after KBrO intake was detected. These results show that KBrO has serious damaging effects and therefore, its use should be avoided.
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