Delayed‐type hypersensitivity to contact allergens in psoriasis

Abstract

The possibility for patch testing procedures to detect contact allergy was examined in 85 hospitalized patients with forms of psoriasis. Exclusion criteria were active lesions on the back, the use of strong topical corticosteroids, methotrexate, cyclosporin and UV therapy. After screening, a group of 47 patients with different forms of psoriasis were selected for patch testing. Personal history, including topical treatment, occupation and domestic circumstances, were reasons to extend the standard series of allergens. Tars, nickel sulfate, perfume and balsam of Peru scored high. The overall positive rate was 68%. This is higher than that observed in earlier studies. The unexpected results are discussed in the light of the possible mechanism of action.

Analysis of selected allergic reactions among psoriatic patients

“…The research concerning contact hypersensitivity in psoriasis patients Potato Carrot have not shown univocal results. There are some weakly expressed data about contact hypersensitivity in psoriasis patients contrary to strongly expressed hypersensitivity connected with contact allergens in patients with palmoplantar pustulosis [15][16][17]. Our research shows that there is weakly expressed contact hypersensitivity in psoriasis patients.…”

Implication of Responses to Bacterial Heat Shock Proteins, Chronic Microbial Infections, and Dental Metal Allergy in Patients With Pustulosis Palmaris Et Plantaris

“…Some HSPs could be targets for T cells possessing ␥␦-receptors, which are predominant in skin with various immune disorders. It has been demonstrated that antibodies that reacted with periodontopathic HSPs can be found in serum samples from patients with periodontal disease 9,14,23,24) . These data suggest that HSP-producing chronic infectious bacteria could trigger PPP.…”

“…Evidence for such exceptional cases include reproducible positive patch test reactions to various metals and analytical results of dental metal testing demonstrating the presence of metals to which the patients are undoubtedly hypersensitive. Dramatic curative effects of allergenic metal elimination have been reported 9,17) . It is valuable to examine the relationship between dental metal allergy and other humoral immune responses to various antigens in patients with PPP.…”

“…The etiology of PPP has not yet been clarified. A close relationship between infection and PPP has been reported by many research groups; these include infections by Streptococcus pyogenes 3) , Mycobacterium 9) , human papilloma virus 22) , Coxsackie B virus 13) , and fungi 1,6) . Heat shock proteins (HSPs) are highly conserved molecules and distributed widely in nature 27) .…”

Psoriasis and Contact Sensitivitiy

“…Deriye temas ederek dermatite neden olan iritan ya da alerjen maddeler psoriasis lezyonlarını tetikleyebilen ekzojen faktörler arasında sayılmaktadırlar. Birçok araştırmacı tedaviye dirençli olan el içi-ayak tabanı gibi lokalizasyonlardaki psoriasis lezyonlarında kontakt dermatitin hastalığı tetikleyen bir faktör olabileceğini ve Koebner fenomeni nedeniyle kontakt dermatit kliniğinin maskelenebileceğini düşünmüşlerdir (1,2). Ayrıca psorisis lezyonlarında dermal papillalar üzerinde ince olan epidermisin bariyer fonksiyonunun tedavide sık kullanılan keratolitik ajanlar nedeniyle bozulması alerjen maddelerin deriye penetrasyonunu kolaylaştırabilir (2).…”