Delayed skin reaction after mRNA-1273 vaccine against SARS-CoV-2: a rare clinical reaction

Hoff, Norman-Philipp; Freise, Noemi F.; Schmidt, Albrecht; Firouzi-Memarpuri, Parnian; Reifenberger, Julia; Luedde, Tom; Bölke, Edwin; Meller, Stephan; Homey, Bernhard; Feldt, Torsten; Jensen, Björn; Keitel, Verena; Schmidt, Livia; Maas, Kitti; Haussmann, Jan; Tamaskovics, Bálint; Budach, Wilfried; Fischer, Johannes C.; Buhren, Bettina Alexandra; Knoefel, Wolfram Trudo; Schneider, Marion; Gerber, Peter Arne; Pedoto, Alessia; Häussinger, Dieter; Grebe, Olaf; Griensven, Martijn van; Braun, Stephan Alexander; Salzmann, Stefan; Rezazadeh, Amir; Matuschek, Christiane

doi:10.1186/s40001-021-00557-z

Cited by 17 publications

(38 citation statements)

References 17 publications

(36 reference statements)

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“…Cutaneous reactions of COVID‐19 vaccine most often occur after the first dose 12,13,16,17,19 which is consistent with Grieco et al' findings 28 . According to our review findings, recurring infrequently after administering the second dose of the COVID‐19 vaccine and only six persons were given the advice do not to apply the second dose due to diffuse urticaria and maculopapular rash.…”

Section: Discussionsupporting

confidence: 91%

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Cutaneous adverse reactions of COVID ‐19 vaccines: A systematic review

Qaderi

Golezar

Mardani³

et al. 2022

Dermatologic Therapy

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Background: Numerous vaccines are implementation for the prevention of severe course and lethal outcome of coronavirus disease 2019 .Objective: This systematic review aims to summarize and integrated the ndings of studies regarding cutaneous side effects of COVID-19 vaccines.Methods: This systematic review conducted by searching the scienti c databases of PubMed, Scopus, Science direct, and Web of knowledge from the beginning of the COVID-19 to10/5/2021. Articles were reviewed and analyzed based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist.Results: Seventeen studies were included after the screening of search results based on to the eligibility criteria. The results showed that injection site reactions and delayed large local reactions were the most common side effects arising from all vaccine types. Most cutaneous reactions occurred in middleaged women, after the rst dose of vaccine, and 1-21 days after vaccination. Most cutaneous reactions were self-limiting, need little or no therapeutic intervention, and were not regarded as a barrier to injecting a second dose. Limitations:Conclusion: In certain groups such as patients with allergies and a history of local injection reactions, pre-vaccination counseling and the use of appropriate medications may be helpful. However, more studies are needed to investigate the side effect pro le of all COVID-19 vaccines.This study was a systematic review that was performed by searching the scienti c databases of PubMed, Scopus, Science direct, and Web of knowledge for relevant English articles published from the beginning of the COVID-19 to10/5/2021. Analysis of retrieved articles was performed in four-step selection process of identi cation, screening, eligibility, and inclusion criteria, based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist. Search strategyWe conducted a comprehensive search on the scienti c databases using MeSH keywords including: COVID-19 OR SARS-CoV-2 OR Coronavirus OR "Corona virus" OR COVID; AND vaccine OR vaccines OR vaccination OR sputnik OR astrazeneca OR P zer OR sinopharm OR moderna OR bharat OR "Johnson &Johnson"; AND effect OR reaction OR adverse OR subsequence OR consequence OR complication OR outcome OR aftereffect OR disorder OR disturbance OR sequel; AND skin OR cutaneous OR Derm OR dermis OR keratinocyte OR dermatology.To nd more studies, the references in the relevant papers were also followed up. The search was performed by two independent researchers. Study selectionIn the rst step two researchers reviewed the retrieved articles and removed the duplicates. In other steps, the researchers screened the title and abstract of the records and the ineligible studies were removed. Then, the authors surveyed the full-text of the remaining studies based on inclusion and exclusion criteria and the eligible studies (case report, case series, and cross-sectional) were identi ed.We excluded the articles which were topic to at least one of the following criteria: N...

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Section: Discussionsupporting

confidence: 91%

“…Besides, 18 individuals did not plan to receive the second dose 8,16,17 . No long‐term cutaneous sequelae remain in any of the affected persons 13 …”

Section: Resultsmentioning

confidence: 99%

Cutaneous adverse reactions of COVID ‐19 vaccines: A systematic review

Qaderi

Golezar

Mardani³

et al. 2022

Dermatologic Therapy

View full text Add to dashboard Cite

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“…In the study by Català et al, the ‘COVID arm’ was much more common in females (95.4%) and is more likely to be associated with systemic symptoms (64.6%) than other post-vaccination eruptions [ 2 ]. It can manifest as a solitary pink patch or plaque associated with erythema, induration, pruritus, and/or tenderness ( Figure 1 ) [ 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 ]. Severe reactions with lesion sizes of >10 cm have been reported [ 9 ].…”

Section: Resultsmentioning

confidence: 99%

“…Histopathology of DLLLs showed perivascular lymphocytic infiltrates with eosinophils and scattered mast cells consistent with a delayed T-cell mediated hypersensitivity reaction [ 9 , 89 ]. The presence of prominently dilated vessels with edematous endothelial layers was a consistent feature [ 13 ]. ‘COVID arm’ typically resolves within one week of treatment with topical corticosteroid, oral antihistamines, and symptomatic therapy.…”

Section: Resultsmentioning

confidence: 99%

Cutaneous Complications of mRNA and AZD1222 COVID-19 Vaccines: A Worldwide Review

et al. 2022

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Because of the increasing emergence of cutaneous reactions from COVID-19 vaccines worldwide, we investigated the published reports of these complications. We searched the PubMed, Google Scholar, and Scopus databases and the preprint server bioRxiv for articles on cutaneous complications linked to mRNA-1273 (Moderna), BNT162b2 (Pfizer–BioNTech), and AZD1222 (AstraZeneca–Oxford University) vaccines published until 30 September 2021. Eighty studies describing a total of 1415 reactions were included. Cutaneous reactions were more prevalent in females (81.6%). Delayed large local reactions were the most common complication (40.4%), followed by local injection site reactions (16.5%), zoster (9.5%), and urticarial eruptions (9.0%). Injection site and delayed large local reactions were predominantly caused by the mRNA-1273 vaccine (79.5% and 72.0%, respectively). BNT162b2 vaccination was more closely linked to distant reactions (50.1%) than mRNA-1273 (30.0%). Zoster was the most common distant reaction. Of reactions with adequate information for both vaccine doses, 58.3% occurred after the first dose only, 26.9% after the second dose only, and 14.8% after both doses. Overall, a large spectrum of cutaneous reaction patterns occurred following the COVID-19 vaccination. Most were mild and without long-term health implications. Therefore, the occurrence of such dermatologic complications does not contraindicate subsequent vaccination.

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“…the of an adaptive immune response, as suggested by previous publications. 8 The American Academy of Dermatology and the International League of Dermatological Societies organized a study further characterizing the morphology of cutaneous reactions for both the first and second doses of the available mRNA vaccines. Between December 24, 2020 and February 14, 2021, they gathered relevant information for a total of 414 patients, and 71 cases were reported after receiving mRNA vaccines.…”

mentioning

confidence: 99%

Postoperative Cutaneous Manifestations as the First Presentation of COVID-19 Infection or a Postvaccination Sequel

Minawi

Abdelgawad

Saloussy

et al. 2022

Plastic and Reconstructive Surgery - Global Open

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Summary: Since its first emergence, coronavirus disease 2019 (COVID-19) took the world by surprise, causing more than two million deaths and 100 million infections to date. The virus’s most prevalent clinical symptoms have become well known, yet the rarer symptoms, on the other hand, need to be more widely recognized. Various studies have reflected the possibilities of potential skin lesions being the presenting signs of COVID-19 infection. Acquaintance with the cutaneous presentations of COVID-19 may help in early diagnosis and management of infected patients. Herein we report two cases that presented for plastic surgical interventions in which skin manifestations were the first indicators of COVID-19 infection or postvaccination sequel. The cases were operated upon in different hospitals by different surgical teams.

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Delayed skin reaction after mRNA-1273 vaccine against SARS-CoV-2: a rare clinical reaction

Cited by 17 publications

References 17 publications

Cutaneous adverse reactions of COVID ‐19 vaccines: A systematic review

Cutaneous adverse reactions of COVID ‐19 vaccines: A systematic review

Cutaneous Complications of mRNA and AZD1222 COVID-19 Vaccines: A Worldwide Review

Postoperative Cutaneous Manifestations as the First Presentation of COVID-19 Infection or a Postvaccination Sequel

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