Delayed emergence of striatal dopaminergic hyperactivity after anterolateral ischemie cortical lesions in humans; Evidence from turning behavior

Bracha, H. Stefan; Lyden, Patrick D.; Khansarinia, Saeid

doi:10.1016/0006-3223(89)90174-1

Cited by 26 publications

(7 citation statements)

References 37 publications

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“…Strong directional turning biases in rodents and humans can result from experimental lesions or ischemia, respectively, that alter the pathways in the forebrain related to motor function [ 11 , 24 ]. A stably maintained asymmetric motor activity in our mouse models should also be reflected by asymmetric activity in the brain.…”

Section: Resultsmentioning

confidence: 99%

“…Models of atypical asymmetries in motor behavior in nonhuman animals are rare. One exception is a turning bias, or directional circling, which can occur across species [ 9 – 11 ]. In humans, based on automated rotometer measures, there is a natural or typical tendency to turn in a preferred direction, which correlates with handedness [ 12 – 16 ].…”

Section: Introductionmentioning

confidence: 99%

“…In humans, based on automated rotometer measures, there is a natural or typical tendency to turn in a preferred direction, which correlates with handedness [ 12 – 16 ]. Atypical turning asymmetries can be linked to neurological and neuropsychiatric disorders such as hemi-Parkinson, schizophrenia, and ischemia, resulting in an exaggerated turning in a preferred direction [ 11 , 17 – 20 ].…”

Section: Introductionmentioning

confidence: 99%

“…Paw preference, the acquired tendency to use mostly the left or right paw during a repeated food-reaching task, also correlates with an asymmetry in dopamine levels in the striatum [ 25 ]. Similarly, in human disorders such as hemi-Parkinson or schizophrenia, asymmetric changes in dopamine signaling also appear to underlie atypical turning biases [ 11 , 16 – 20 ].…”

Section: Introductionmentioning

confidence: 99%

“…Cortical glutamatergic input converges with dopaminergic input onto the principal projection neurons of the striatum, the gamma-Aminobutyric acid-producing (GABAergic) medium spiny neurons, to regulate motor output, suggesting that input from the cortex may also contribute to asymmetric striatal output and therefore asymmetric motor behavior. Examples of alterations in glutamatergic input causing atypical motor asymmetries include patients with cortical ischemic lesions and exhibiting hemispatial neglect [ 11 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

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Early uneven ear input induces long-lasting differences in left–right motor function

et al. 2018

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How asymmetries in motor behavior become established normally or atypically in mammals remains unclear. An established model for motor asymmetry that is conserved across mammals can be obtained by experimentally inducing asymmetric striatal dopamine activity. However, the factors that can cause motor asymmetries in the absence of experimental manipulations to the brain remain unknown. Here, we show that mice with inner ear dysfunction display a robust left or right rotational preference, and this motor preference reflects an atypical asymmetry in cortico-striatal neurotransmission. By unilaterally targeting striatal activity with an antagonist of extracellular signal-regulated kinase (ERK), a downstream integrator of striatal neurotransmitter signaling, we can reverse or exaggerate rotational preference in these mice. By surgically biasing vestibular failure to one ear, we can dictate the direction of motor preference, illustrating the influence of uneven vestibular failure in establishing the outward asymmetries in motor preference. The inner ear–induced striatal asymmetries identified here intersect with non–ear-induced asymmetries previously linked to lateralized motor behavior across species and suggest that aspects of left–right brain function in mammals can be ontogenetically influenced by inner ear input. Consistent with inner ear input contributing to motor asymmetry, we also show that, in humans with normal ear function, the motor-dominant hemisphere, measured as handedness, is ipsilateral to the ear with weaker vestibular input.

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Section: Resultsmentioning

confidence: 99%