Delayed brainstem auditory evoked responses in diabetic patients

Abstract

The incidence of subclinical central diabetic neuropathy is unclear due to difficulty in detecting latent alterations of central neural transmission process. The aim of this study was to evaluate a central neuroconductive mechanism in diabetics by brainstem auditory evoked responses (BAER). We found increased latencies of peaks I, III, V in diabetics as compared to control subjects. These BAER abnormalities were demonstrated in 62 per cent of insulin-controlled diabetics and in 33 per cent o patients treated by diet, or peroral drugs. No alterations in brainstem responses were observed in patients with latent diabetes. We did not find any correlation between the BAER abnormalities and the duration of the disease, the blood glucose level or the level of control of the diabetes.

Effects of the Chinese Yi-Qi-Bu-Shen Recipe extract on brainstem auditory evoked potential in rats with diabetes

“…It has been confirmed by experiments that all BAEP waves PL and IPL were significantly delayed in diabetes patients (Donald et al, 1981;Buller et al, 1988;Liu et al, 1993;Ryu and Chin, 1995). Additionally, He et al (2004) demonstrated that there were significant prolongations of BAEP waves I, II, IV, and V PL of rats with diabetes by the 28th day, and wave III PL and I-V IPL were delayed on the 42th day, which was positively correlated with their courses.…”

“…In 1981, Donald et al (1981) made use of brain stem auditory evoked potential (BAEP) to study diabetes. Afterward, research showed that waves V peak latency (PL) and waves I-V interpeak latency (IPL) were significantly delayed in diabetes (Buller et al, 1988;Liu et al, 1993;Ryu and Chin, 1995) suggesting that the central brainstem function was damaged. There is no effective treatment or drug for electrophysiological abnormalities, and the mechanism leading to the functional loss of brain neurons is unknown.…”

Evaluation of hearing loss in patients with type 2 diabetes mellitus

“…[10][11][12] However, not all authors agree that diabetes mellitus can lead to a sensorineural hearing impairment. [13][14][15] The effects of different variables such as duration of diabetes, blood sugar control, and presence of end-organ damage on hearing loss have yet not been clarified despite several studies on this topic. 9 Although there is mounting evidence for a relationship between diabetes and hearing impairment the awareness of auditory organ involvement in the course of diabetes is still not widespread among healthcare providers involved in diabetes care.…”

Impulse activity of neurons of the sensorimotor cortex of rabbits with experimental diabetes mellitus

“…Along with biochemical and molecular-biological studies, electrophysiological investigations (using electroencephalography [12] and the method of evoked potentials [8,11] are being carried out; however, studies directly devoted to specilicities of neuronal activity are lacking.…”