Effects of the Chinese Yi-Qi-Bu-Shen Recipe extract on brainstem auditory evoked potential in rats with diabetes

Liu, De Shan; Gao, Wei; Lin, Wei; Hao, Yuan Yuan; Zhong, Li Hong; Li, Wei; Inoguchi, Toyoshi; Takayanagi, Ryoichi

doi:10.1016/j.jep.2011.05.033

Cited by 6 publications

(9 citation statements)

References 21 publications

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“…The BAEP measurements were similar in shape and amplitude to those recorded by other laboratories (Galbraith et al, 2006;Jirka et al, 1985;Liu et al, 2011;Rice et al, 2011). As shown in Figure 1, BAEP horizontal channel P1 and P2 from all frequencies were clear.…”

Section: Resultssupporting

confidence: 81%

Altered brainstem auditory evoked potentials in a rat central sensitization model are similar to those in migraine

Arakaki¹,

Galbraith²,

Pikov³

et al. 2014

Brain Research

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Migraine symptoms often include auditory discomfort. Nitroglycerin (NTG)-triggered central sensitization (CS) provides a rodent model of migraine, but auditory brainstem pathways have not yet been studied in this example. Our objective was to examine brainstem auditory evoked potentials (BAEPs) in rat CS as a measure of possible auditory abnormalities. We used four subdermal electrodes to record horizontal (h) and vertical (v) dipole channel BAEPs before and after injection of NTG or saline. We measured the peak latencies (PLs), interpeak latencies (IPLs), and amplitudes for detectable waveforms evoked by 8, 16, or 32 KHz auditory stimulation. At 8 KHz stimulation, vertical channel positive PLs of waves 4, 5, and 6 (vP4, vP5, and vP6), and related IPLs from earlier negative or positive peaks (vN1-vP4, vN1-vP5, vN1-vP6; vP3-vP4, vP3-vP6) increased significantly 2 hours after NTG injection compared to the saline group. However, BAEP peak amplitudes at all frequencies, PLs and IPLs from the horizontal channel at all frequencies, and the vertical channel stimulated at 16 and 32 KHz showed no significant/consistent change. For the first time in the rat CS model, we show that BAEP PLs and IPLs ranging from putative bilateral medial superior olivary nuclei (P4) to the more rostral structures such as the medial geniculate body (P6) were prolonged 2 hours after NTG administration. These BAEP alterations could reflect changes in neurotransmitters and/or hypoperfusion in the midbrain. The similarity of our results with previous human studies further validates the rodent CS model for future migraine research.

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Section: Resultssupporting

confidence: 81%

Altered brainstem auditory evoked potentials in a rat central sensitization model are similar to those in migraine

Arakaki¹,

Galbraith²,

Pikov³

et al. 2014

Brain Research

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“…Ohwi (12 g), Coptis chinensis Franch (3 g) . 8 All nine Chinese herbs in YQBS were provided by Shandong Bokang Traditional Chinese Medicine Co. Ltd. (Qingzhou, China). The above nine crude drugs were decocted and made into powder followed by adding 20 times the amount of water to decoct and concentrate all the drugs 3 times, 2 h each time.…”

Section: Methodsmentioning

confidence: 99%

“…The hybrid medicine formula YQBS is composed of Astragali Radix, Rehmanniae Radix Praeparata, Polygonati Rhizoma, Lycii Fructus, Epimedii Folium, Puerariae Lobatae Radix, Chuanxiong Rhizoma, Atractylodis Rhizoma, and Coptidis Rhizoma, which are mainly used to invigorate the kidney and also to activate blood circulation and eliminate phlegm. 8 Previous limited evidence has suggested the potential therapeutic effect of YQBS on patients with diabetic cognitive dysfunction by lowering their blood glucose and improving their memory, by protecting hippocampal neuronal cells from damage, and by a protective effect on the electrophysiological function of the brain in diabetic rats. 8 , 9 Herein we performed comprehensive analyses to determine the protective effects of YQBS on cognitive dysfunction under diabetic condition and also elucidated the underlying mechanism through characterizing the metabolic neurotransmitters in the hippocampus.…”

Section: Introductionmentioning

confidence: 99%

“… 8 Previous limited evidence has suggested the potential therapeutic effect of YQBS on patients with diabetic cognitive dysfunction by lowering their blood glucose and improving their memory, by protecting hippocampal neuronal cells from damage, and by a protective effect on the electrophysiological function of the brain in diabetic rats. 8 , 9 Herein we performed comprehensive analyses to determine the protective effects of YQBS on cognitive dysfunction under diabetic condition and also elucidated the underlying mechanism through characterizing the metabolic neurotransmitters in the hippocampus.…”

Section: Introductionmentioning

confidence: 99%

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YQBS Improves Cognitive Dysfunction in Diabetic Rats: Possible Association with Tyrosine and Tryptophan Metabolism

Liu¹,

Cai²,

Wang³

et al. 2023

DMSO

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Objective This study is aimed to determine the metabolomic effects of the hybrid medicine formula Yi-Qi-Bu-Shen (YQBS) on the neurotransmitter aspects of cognitive impairment in diabetic rats. Methods In the current study, streptozotocin (STZ) was used to induce diabetic animal model in male Sprague Dawley (SD) rats. After successful establishment of diabetic SD rats’ model, age-matched healthy SD rats and diabetic SD rats were treated with low and high doses of YQBS, and then tested for learning memory ability and analyzed for pathological changes. In addition, neurotransmitter metabolic changes in hippocampal subdivisions of rats from different treated groups were analyzed using liquid chromatography-mass spectrometry (LC-MS) technique. Results YQBS could significantly improve memory-cognitive impairment in diabetic rats as evidenced by the shortening of latency to target and the reduction of latency first entrance to target. Moreover, YQBS also improved the pathological alterations in the hippocampal region in the brains of diabetic rats. Metabolomic analysis showed that the expression of noradrenaline hydrochloride was down-regulated and the expressions of levodopa and 5-hydroxytryptophan were up-regulated in the hippocampal tissues of diabetic rats treated with YQBS. Conclusion These findings demonstrate that YQBS has protective effects against diabetic cognitive dysfunction, which might act through alteration in tyrosine and tryptophan metabolism.

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“…A herbal formula is prepared by boiling the herbal mixture with water before it is administered to the patients, and most in vivo and in vitro experimental models using a herbal formula as a treating agent have dealt with the water extract produced in the laboratory. [ 1 2 ] The therapeutic effect of a herbal formula is attributed to the synergistic property that results from the combination and interaction of bioactive constituents from herbal medicines. [ 3 ] Thus, the extraction method must be designed to produce efficiently the bioactive compounds from the herbal formula, so that those compounds can contribute to exert the curative effect.…”

Section: Introductionmentioning

confidence: 99%

Optimization of the extraction process for the seven bioactive compounds in Yukmijihwang-tang, an herbal formula, using response surface methodology

Shin

Seo

2014

Phcog Mag

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Background:Yukmijihwang-tang (YJT) contains multiple bioactive compounds. Heat-reflux extraction was employed and optimized for the extraction of the bioactive compounds in YJT.Objective:The determination of optimal conditions with maximum yields of bioactive compounds, gallic acid, 5-hydroxymethylfurfural, morroniside, loganin, paeoniflorin, benzoic acid and paeonol, in YJT.Materials and Methods:The extraction ratio (ratio of water to herbal formula), extraction time and extraction number were set as individual values and the yields of the seven compounds were the response values that were optimized with a Box–Behnken design.Results:The optimal conditions obtained from response surface methodology (RSM) were 1:11.99 for the extraction ratio, 94.53 min for the extraction time and 2.21 for the extraction number. Under the optimal conditions, the response value of the experiment closely agreed with the predicted response value.Conclusions:The result suggests that RSM is successfully applied for optimizing the extraction of the marker compounds in YJT.

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Effects of the Chinese Yi-Qi-Bu-Shen Recipe extract on brainstem auditory evoked potential in rats with diabetes

Cited by 6 publications

References 21 publications

Altered brainstem auditory evoked potentials in a rat central sensitization model are similar to those in migraine

Altered brainstem auditory evoked potentials in a rat central sensitization model are similar to those in migraine

YQBS Improves Cognitive Dysfunction in Diabetic Rats: Possible Association with Tyrosine and Tryptophan Metabolism

Optimization of the extraction process for the seven bioactive compounds in Yukmijihwang-tang, an herbal formula, using response surface methodology

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