Delay in the diagnosis and treatment of breast cancer in Vietnam

Nguyen, Sang M.; Nguyen, Quang T.; Nguyen, Lan; Pham, Anh; Luu, Hung N.; Trần, Hương Thanh; Tran, Tien Anh; Shu, Xiao‐Ou

doi:10.1002/cam4.4244

Cited by 18 publications

(22 citation statements)

References 35 publications

(38 reference statements)

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“…Our research revealed that clinical profile and tumor characteristics varied significantly between breast cancer patients in Italy and Vietnam. The variations in presenta-tion, clinicopathological profiles, biomarkers, and molecular subtypes might be attributed to the differences in race, lifestyle, living environment, and late diagnosis expression [3,17,18]. Our findings from this study are roughly in accord with those reported in Vietnam and Italy, respectively [6,9,[18][19][20][21].…”

Section: Discussionsupporting

confidence: 86%

“…Similar characteristics of Vietnamese breast cancer patients were also reported in other recent studies [18,25]. For instance, a study by Vu Hong Thang also compared those features among Vietnamese and Swedish patients with breast cancer [19,26].…”

Section: Discussionsupporting

confidence: 68%

“…Lack of knowledge, being too busy, staying far from treatment facilities, bearing high treatment costs, and not receiving good quality healthcare service, ... might be some reasons leading to the delay in the treatment [10]. In addition, the participation rate in breast cancer screening programs in Vietnam and other Asian countries was lower compared to Western countries [3,18]. There is not enough information provided about screening processes and how screening services are integrated with other areas of the health system.…”

Section: Discussionmentioning

confidence: 99%

“…There is not enough information provided about screening processes and how screening services are integrated with other areas of the health system. Thus, several patients arrived at the hospital when their tumor had already become large in size and their disease stage was late with high grade and accompanying metastasis [18]. Delay in cancer diagnosis is also a major contributor to an increased risk of premature mortality, lower cancer survival rate, and a higher cancer burden.…”

Section: Discussionmentioning

confidence: 99%

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Comparative Study on Clinicopathological Characteristics of Breast Cancer in Vietnam and Italy

Nguyen-Phuong¹,

Nguyễn-Thanh²,

Tanda³

et al. 2022

Clin. Exp. Obstet. Gynecol.

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Background: In Vietnam and Italy, breast cancer (BC) occurs in women more frequently than any other cancer. Vietnam has a substantially lower incidence of breast cancer than Italy, but a higher mortality rate. Most Vietnamese patients present to the hospital with severe tumors at the late stages of diagnosis. The purpose of this study was to compare clinicopathologic features, biomarkers, and subtypes of BC between Vietnamese women and Italian ones. Methods: The sample was collected from all Vietnamese patients undergoing surgery with the diagnosis of primary invasive breast carcinoma in Hue Central Hospital as well as Hue University Hospital in Vietnam during 1 year from April 2016 to April 2017, and from the same category of women in Sassari University Hospital, Italy during the year 2016. The study parameters in both groups consisted of age at diagnosis, tumor size, histologic grade, histologic type, axillary node status, stages of diagnosis, biomarkers (Estrogen Receptor -ER, Progesterone Receptor -PR, Ki-67 cell proliferation marker -Ki-67, Human epidermal growth factor receptor 2 -HER2), and molecular subtypes of BC. Results: 323 patients were collected in total (235 from Sassari, Italy, and 88 from Thua Thien -Hue province, Vietnam). Vietnamese patients were diagnosed at a younger age than Italian patients, at just 52.5 on average, while the figure for Italian was 62. The Vietnamese BC patients also had a bigger tumor in size, higher grade, more axillary node positivity as well as a later stage of disease in comparison with Italian ones. The proportion of ER-positive was higher in the Italian group than that in Vietnam (88.1 vs 55.7%). The high Ki-67 expression prevalence was significantly higher in Vietnamese patients compared with Italian (81.8 vs 45.1%). The HER2-positive rate in Vietnam was 33%, higher than that in Italy (8.1%). Histologic grade and cell proliferation index Ki-67 were significantly correlated with HER2 positivity in both groups. Conclusions: Vietnamese patients demonstrated more aggressive tumor features and worse prognostic biomarkers than Italian patients. The prevalence of HER2 positive and high Ki-67 expression in Vietnamese patients was considerably higher than in Italian patients. The remarkable differences in clinicopathological characteristics between the two populations suggest the diversity of biological tumor, ethnicity, and environment as well as the effectiveness of the screening program.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionsupporting

confidence: 68%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Comparative Study on Clinicopathological Characteristics of Breast Cancer in Vietnam and Italy

Nguyen-Phuong¹,

Nguyễn-Thanh²,

Tanda³

et al. 2022

Clin. Exp. Obstet. Gynecol.

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“…Our previous study described the characteristics of cases, in which 94 (19.2%) participants were diagnosed at stage I, 240 (49.2%) were diagnosed at stage II, and 119 (24.3%) were diagnosed at stage III and IV. 18 …”

Section: Resultsmentioning

confidence: 99%

Menstrual and Reproductive Factors in Association With Breast Cancer Risk in Vietnamese Women: A Case-Control Study

et al. 2022

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Objectives Though menstrual and reproductive factors have been associated with the risk of breast cancer in many populations, very few studies have been conducted among Vietnamese women. This study aimed to assess the association between menstrual and reproductive factors and the risk of breast cancer in Vietnamese women. Methods A retrospective case-control study of 490 breast cancer cases and 468 controls was conducted in Northern Vietnam. Unconditional logistic regression models adjusting for confounders were used to estimate odds ratios (ORs) and their 95% confidence intervals (CIs) for the associations of menstrual and reproductive factors with the risk of breast cancer; overall and by cancer subtype. Results Among breast cancer patients, the luminal B subtype was the most frequent (48.6%), followed by HER2-overexpressing (24.5%), luminal A (16.7%), and triple-negative breast cancer (TNBC; 10.2%). Among menopausal women, menopausal age at 50 years or older (OR = 1.71, 95% CI: 1.15-2.57 vs. <50 y) was associated with an increased risk of breast cancer. Earlier age at menarche (<13 y) was associated with a significantly increased risk of breast cancer (OR = 2.66, 95% CI: 1.08-7.51) among premenopausal women only and the luminal A subtype of breast cancer (OR = 3.06, 95% CI: 1.04-8.16). Having more than two children was associated with a reduced risk of premenopausal (OR = .42, 95%CI: .21-.83), luminal B (OR = .43, 95% CI: .24-.79), and TNBC (OR = .34, 95% CI: .14-.89). Later menopause was positively associated with the risk of breast cancer with HER2 overexpression (OR = 2.19, 95% CI: 1.14-4.23). Conclusion Associations of menstrual and reproductive factors with breast cancer among Vietnamese women, particularly for among premenopausal women and for the luminal A subtype, are generally consistent with those reported from other countries. These findings suggest that changes in menstrual and reproductive patterns among young Vietnamese women may contribute to the recent rising incidence of breast cancer in Vietnam.

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