Degradation of Structurally Defined Graphene Nanoribbons by Myeloperoxidase and the Photo‐Fenton Reaction

Luan, Xiangfeng; Martín, Cristina; Zhang, Pengfei; Li, Qian; Vacchi, Isabella Anna; Delogu, Lucia Gemma; Mai, Yiyong; Bianco, Alberto

doi:10.1002/anie.202008925

Cited by 28 publications

(19 citation statements)

References 57 publications

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“…demonstrated that carboxyl‐functionalized graphene nanoribbons (GNRs) can be efficiently degraded by MPO or photo‐Fenton reaction. The results showed that both MPO and photo‐Fenton reactions degraded GNRs almost completely after 120 h. [ 44 ] Table 1 lists the enzymes studied to date, their source, and the redox potentials of their intermediates during the peroxidase cycle. [ 17,43,45,46 ] Previous studies in this domain have already elucidated these enzymes’ action mechanisms, especially HRP and MPO.…”

Section: Biodegradation Of Carbon‐based Nanomaterialsmentioning

confidence: 99%

Biodegradation of Carbon‐Based Nanomaterials: The Importance of “Biomolecular Corona” Consideration

Mokhtari‐Farsani

Hasany

Lynch

et al. 2021

Adv Funct Materials

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It has been over a decade since oxidative enzymes were first used to degrade carbon‐based nanomaterials (CBNs). Although enormous progress has been achieved in this field, many questions and problems remain unresolved that need to be answered to usher these materials toward their true destiny. Nanobioscience researchers now know that ignoring the biomolecular corona (BMC) in nanobiomedical studies, either inadvertently or intentionally, is by no means justified. However, a major drawback to progress is that BMC effects on CBN biodegradation have been omitted from a large number of studies. What's more, many studies in the field have eliminated the BMC source in the relevant experiments. Thus, the most critical question that one needs to probe is whether the BMC and its characteristics affect the biodegradability of CBNs? In this conceptual perspective paper, recent progress and significant research in CBNs biodegradation are summarized. Then, the importance of the BMC and its possible impacts on the biodegradation of CBNs are thoroughly explored as a conceptual guide. Finally, remaining challenges and the direction of future research are provided, and barriers that need to be overcome to advance the field are discussed including recommendations regarding BMC considerations and study design and reporting guidelines.

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Section: Biodegradation Of Carbon‐based Nanomaterialsmentioning

confidence: 99%

Biodegradation of Carbon‐Based Nanomaterials: The Importance of “Biomolecular Corona” Consideration

Mokhtari‐Farsani

Hasany

Lynch

et al. 2021

Adv Funct Materials

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“…[ 154 , 155 ] This process transforms epoxy groups of GFMs to more energetically favorable carbonyl groups and results in the rupture of underlying C—C bonds. [ 154 , 156 , 157 ] Finally, GFMs are digested into oxidized polycyclic aromatic hydrocarbons (PAHs) and carbon dioxide, [ 155 , 158 , 159 ] and exported from macrophages via exocytosis. The dispersed large GFMs (>250 nm) will trigger invagination of membrane and be engulfed into phagosome vesicles of macrophages.…”

Section: Discussionmentioning

confidence: 99%

Development of Graphene‐Based Materials in Bone Tissue Engineaering

et al. 2021

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Currently, general treatments of criticalsized bone defects include autografts, allografts, and the use of bone regeneration biomaterials. [1] Autograft is the gold standard approach due to its satisfying osteogenicity. But it also faces drawbacks such as an invasive surgical operation for bone harvest and scarcity of available donor sites. [2] Allograft is accompanied by the risk of disease transmission and immunological rejection. [2] Therefore, significant efforts have been devoted to finding alternative approaches for bone regeneration. Bone tissue engineering (BTE) provides a promising alternative strategy to realize higher-level restoration of bone defects. BTE exploits the elaborate combination of scaffolds, seeding cells, and biological factors to form a functional substitute or assist in situ regeneration. In most BTE research, stem cells are implanted into defective bone sites with the support of a biomaterial-based scaffold and are supposed to proliferate and differentiate into osteoblasts to promote bone regeneration. However, the performances of many current BTE systems could not meet the therapeutic expectation due to problems such as insufficient osteogenic differentiation and limited vascularization. [3][4][5] Many studies tried to improve the performance of BTE via enhancing the properties of the biomaterial-based scaffold. [6] In addition to traditional macroor microscale forms of metals, ceramics, and polymers, their nanoscale counterparts have been extensively explored for BTE due to their unique properties. [7][8][9][10] Ever since Andre Geim and Konstantin Novoselov [11] discovered a simple and feasible method for graphene isolation, graphene family materials (GFMs) have attracted great interest in regenerative medicine and tissue engineering. In BTE, bGBMs show promising potentials such as mechanical strength, high specific surface, and adsorption ability. [12][13][14][15][16][17] According to the composition, bGBMs could be categorized into GFMs and GFMs-containing composite materials (GCMs). GFMs refer to graphene and its derivatives, containing 0D graphene quantum dots (GQDs), 2D graphene (GR), graphene oxide (GO), and reduced graphene oxide (rGO), 3D graphite, etc. Among them, GQDs, GR, GO, and rGO could be obtained by chemical approaches using graphite as the starting material. GCMs are composite materials consisting of GFMs and other materials such Bone regeneration-related graphene-based materials (bGBMs) are increasingly attracting attention in tissue engineering due to their special physical and chemical properties. The purpose of this review is to quantitatively analyze mass academic literature in the field of bGBMs through scientometrics software CiteSpace, to demonstrate the rules and trends of bGBMs, thus to analyze and summarize the mechanisms behind the rules, and to provide clues for future research. First, the research status, hotspots, and frontiers of bGBMs are analyzed in an intuitively and vividly visualized way. Next, the extracted important subjects such as fabricatio...

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“…HOCl produced by peroxidase from H 2 O 2 could be a major cause of the biodegradation of carbon nanomaterials [ 149 , 150 , 151 ]. Several studies have confirmed that recombinant hMPO is able to degrade single-layer and multi-layer GOs [ 153 , 154 ], and that the degradation products are non-toxic [ 155 ]. Through other studies, researchers have shown that graphene-based materials can be degraded by hMPO [ 153 ], recombinant eosinophil peroxidase [ 156 ], and HRP [ 153 , 157 ].…”

Section: Toxicitymentioning

confidence: 99%

Characteristics of Graphene Oxide for Gene Transfection and Controlled Release in Breast Cancer Cells

Grilli

Gohari

Zou

2022

IJMS

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Functionalized graphene oxide (GO) nanoparticles are being increasingly employed for designing modern drug delivery systems because of their high degree of functionalization, high surface area with exceptional loading capacity, and tunable dimensions. With intelligent controlled release and gene silencing capability, GO is an effective nanocarrier that permits the targeted delivery of small drug molecules, antibodies, nucleic acids, and peptides to the liquid or solid tumor sites. However, the toxicity and biocompatibility of GO-based formulations should be evaluated, as these nanomaterials may introduce aggregations or may accumulate in normal tissues while targeting tumors or malignant cells. These side effects may potentially be impacted by the dosage, exposure time, flake size, shape, functional groups, and surface charges. In this review, the strategies to deliver the nucleic acid via the functionalization of GO flakes are summarized to describe the specific targeting of liquid and solid breast tumors. In addition, we describe the current approaches aimed at optimizing the controlled release towards a reduction in GO accumulation in non-specific tissues in terms of the cytotoxicity while maximizing the drug efficacy. Finally, the challenges and future research perspectives are briefly discussed.

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Degradation of Structurally Defined Graphene Nanoribbons by Myeloperoxidase and the Photo‐Fenton Reaction

Cited by 28 publications

References 57 publications

Biodegradation of Carbon‐Based Nanomaterials: The Importance of “Biomolecular Corona” Consideration

Biodegradation of Carbon‐Based Nanomaterials: The Importance of “Biomolecular Corona” Consideration

Development of Graphene‐Based Materials in Bone Tissue Engineaering

Characteristics of Graphene Oxide for Gene Transfection and Controlled Release in Breast Cancer Cells

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