Degradation of methoxy-poly (ethylene glycol)-block-poly(α-carboxyl-ε-caprolactone)/magnetite nanocomposites in vitro polymer degradation and stability

Yang, Li; Liu, Yu; Shuai, Shirong; Zhao, Cong; Zhou, Kanghong; Ge, Wei; Hao, Jianyuan

doi:10.1016/j.polymdegradstab.2020.109191

Cited by 5 publications

(8 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Emulsification/solvent evaporation represents an efficient, facile and versatile method to obtain biopolymer systems (particles, spheres, capsules) for unconventional pharmaceutical formulations [ 59 , 60 ]. This method is suitable to develop micro-/nano-carriers for various compounds, including inorganic nanostructures [ 61 , 62 ], antimicrobial agents [ 63 ], chemodrugs [ 64 , 65 ] and liposoluble drugs [ 66 , 67 ].…”

Section: Resultsmentioning

confidence: 99%

Composite P(3HB-3HV)-CS Spheres for Enhanced Antibiotic Efficiency

et al. 2021

View full text Add to dashboard Cite

Natural-derived biopolymers are suitable candidates for developing specific and selective performance-enhanced antimicrobial formulations. Composite polymeric particles based on poly(3-hydroxybutyrate-co-3-hydroxyvalerate) and chitosan, P(3HB-3HV)-CS, are herein proposed as biocompatible and biodegradable delivery systems for bioproduced antibiotics: bacitracin (Bac), neomycin (Neo) and kanamycin (Kan). The stimuli-responsive spheres proved efficient platforms for boosting the antibiotic efficiency and antibacterial susceptibility, as evidenced against Gram-positive and Gram-negative strains. Absent or reduced proinflammatory effects were evidenced on macrophages in the case of Bac-/Neo- and Kan-loaded spheres, respectively. Moreover, these systems showed superior ability to sustain and sustain the proliferation of dermal fibroblasts, as well as to preserve their ultrastructure (membrane and cytoskeleton integrity) and to exhibit anti-oxidant activity. The antibiotic-loaded P(3HB-3HV)-CS spheres proved efficient alternatives for antibacterial strategies.

show abstract

Section: Resultsmentioning

confidence: 99%

Composite P(3HB-3HV)-CS Spheres for Enhanced Antibiotic Efficiency

et al. 2021

View full text Add to dashboard Cite

show abstract

“…For example, the aging of methoxy-poly(ethylene glycol)-block-poly(acarboxyl-ε-cap-rolactone) (mPEG-b-PCCL) has been studied by the 1 H NMR spectra. 127 The signals at 4.11, 3.41, 1.68, and 0.90 ppm could be ascribed to the PCCL. These signals declined gradually with prolonged aging time, while no new peaks appeared (Figure 22A).…”

Section: Peak Assignment and Spectral Analysis By Nmr For Aged Polymersmentioning

confidence: 99%

“…CI values are widely applied to evaluate the aging evolution for polymers . Costa and Rocco found that the area ratio of 937 to 1161 cm –1 could be used to estimate variations of crystallinity for polyamide .…”

Section: Characterization For Chain Scission/cross-linking In Acceler...mentioning

confidence: 99%

“…To provide a semiquantitative study on the aging behavior, the ratio arising from the different segments in the aged polymers could be estimated. For example, the aging of methoxy-poly(ethylene glycol)- block -poly(acarboxyl-ε-caprolactone) (mPEG- b -PCCL) has been studied by the 1 H NMR spectra . The signals at 4.11, 3.41, 1.68, and 0.90 ppm could be ascribed to the PCCL.…”

Section: Characterization For Chain Scission/cross-linking In Acceler...mentioning

confidence: 99%

See 1 more Smart Citation

Characterization Techniques of Polymer Aging: From Beginning to End

Tian

Lin

et al. 2023

Chem. Rev.

View full text Add to dashboard Cite

Polymers have been widely applied in various fields in the daily routines and the manufacturing. Despite the awareness of the aggressive and inevitable aging for the polymers, it still remains a challenge to choose an appropriate characterization strategy for evaluating the aging behaviors. The difficulties lie in the fact that the polymer features from the different aging stages require different characterization methods. In this review, we present an overview of the characterization strategies preferable for the initial, accelerated, and late stages during polymer aging. The optimum strategies have been discussed to characterize the generation of radicals, variation of functional groups, substantial chain scission, formation of low-molecular products, and deterioration in the polymers' macro-performances. In view of the advantages and the limitations of these characterization techniques, their utilization in a strategic approach is considered. In addition, we highlight the structure−property relationship for the aged polymers and provide available guidance for lifetime prediction. This review could allow the readers to be knowledgeable of the features for the polymers in the different aging stages and provide access to choose the optimum characterization techniques. We believe that this review will attract the communities dedicated to materials science and chemistry.

show abstract

“…With the growing problem of white pollution, degradable polymer materials are attracting more and more attention because polymer materials that can be degraded at controllable speed could be used in every kind of fields [ 1 , 2 , 3 , 4 , 5 , 6 ]. So, the study of influence factors to degradability and degradable speed of polymer materials has important scientific significance.…”

Section: Introductionmentioning

confidence: 99%

Effect of Homochirality of Dipeptide to Polymers’ Degradation

Yang

et al. 2020

Polymers

View full text Add to dashboard Cite

As natural polymer materials, proteins are readily biodegradable, interestingly, the synthetic polyamides (PAs) that are based on the same amide bonds (also called peptide bonds in proteins) are barely degradable. Whether did the chirality and configuration of the amino acids play an important role. By using different configuration of amino acids, 4 types of polyamide-imides (PAIs) containing dipeptides of LL, DL, LD, and DD configurations, respectively, were synthesized. It was found that the PAIs based on natural LL configuration of dipeptide structure are much more readily biodegradable than those based on non-natural LD, DL, and DD configuration of dipeptides. It was confirmed that the natural L-configuration of amino acids play a critical role in degradability of proteins. And it also suggested that different type and amount of peptide fragments can be introduced in polymer to create series of polymer materials that can be biodegraded at controllable speed.

show abstract

Degradation of methoxy-poly (ethylene glycol)-block-poly(α-carboxyl-ε-caprolactone)/magnetite nanocomposites in vitro polymer degradation and stability

Cited by 5 publications

References 36 publications

Composite P(3HB-3HV)-CS Spheres for Enhanced Antibiotic Efficiency

Composite P(3HB-3HV)-CS Spheres for Enhanced Antibiotic Efficiency

Characterization Techniques of Polymer Aging: From Beginning to End

Effect of Homochirality of Dipeptide to Polymers’ Degradation

Contact Info

Product

Resources

About