Definition of prepartum hyperketonemia in dairy goats

Doré, Vincent; Dubuc, J.; Belanger, Anne-Marie; Buczinski, Sébastien

doi:10.3168/jds.2014-9172

Cited by 30 publications

(24 citation statements)

References 28 publications

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“…Mondal and Prakash (2004) explained that the concentration of the growth hormone in the plasma of buffaloes decreases along with lipolysis resulting in less NEFA in the plasma as they become older. An increase in BHB in goat blood determined with increased age was within the physiological range, since Doré et al (2015) reported a hypoketonemia definition based on BHB concentrations from ≥ 0.4 to ≥ 0.9 mmol L −1 . According to Herdt (2000) BHB is more likely a reflection of nutritional status and less constrained physiologically.…”

Section: Discussionmentioning

confidence: 78%

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Haemato-biochemical profile and acid–base status of Croatian spotted goats of different ages

et al. 2019

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The aim of the present research was to determine the haemato-biochemical profile and blood acid–base status of Croatian spotted goats in a traditional Mediterranean production system. The 60 non-gravid female Croatian spotted goats of different ages were included in the research. They were divided into four groups of 15 goats according to age: group I – ≤1 year old; group II – 2–3 years; group III – 3–6 years; and group IV – 7–10 years. Haematological parameters were determined in whole blood, biochemical parameters in serum and acid–base status in plasma by automatic analyser. Total leukocyte number (WBC), haemoglobin (HGB) and mean corpuscular volume (MCV) in the blood were the highest, while mean haemoglobin concentration in erythrocytes (MCHCs) was the lowest in yearlings compared to other groups. Concentrations of urea, Mg, Cl, non-esterified fatty acids (NEFAs) and lactate were the highest in yearlings. Concentrations of Ca, Na, total cholesterol, high-density lipoprotein (HDL), very low-density lipoprotein (VLDL) and beta hydroxybutyrate (BHB) as well as the activity of alanine aminotransferase (ALT) were higher in older goats compared to yearlings, while the opposite was determined for the activities of creatine kinase (CK) and alkaline phosphatase (ALP). Values of pH, the strong ion difference (SID), anion gap (AG) and z values as well as the content of chemnormalHCOnormal3 and total pressure of carbon dioxide (chemnormalctCOnormal2) were higher in older goats compared to yearlings. The results obtained may help in monitoring the health and nutritional status and improve the management of Croatian spotted goats. Based on the results of the present study, the effect of age needs to be included in the model when preparing the reference values for the haemato-biochemical profile and acid–base status of goats.

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Section: Discussionmentioning

confidence: 78%

“…A tendency of SOD and GPx activity decreased with age was found in serum. Dubreuil et al (2005) observed a decrease in GPx in the serum of ewes with age when comparing yearlings and ≥ 4-year-old ewes.…”

Section: Discussionmentioning

confidence: 79%

Haemato-biochemical profile and acid–base status of Croatian spotted goats of different ages

et al. 2019

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“…Together with NEFA concentrations, levels of blood ketones are also considered useful for determination of energy status in ruminants, while hypoglycaemia is recognized as an indication of low energy intake (FERNÁNDEZ et al, 2007;DORÉ et al, 2015). To our knowledge, there are no reference values for NEFA in goats; KANEKO et al (2008) mention a very wide range for cows (0.378 -3.78 mmol/L), but none for sheep and goats.…”

Section: Discussionmentioning

confidence: 99%

“…A BHB blood threshold of ≥0.86 mmol/L was proposed for dairy goats by BANI ISMAIL et al (2008) as an acceptable value to define hyperketonaemia to predict pregnancy toxaemia, and in a study by DORÉ et al (2015) the hyperketonaemia definition based on pregnancy toxaemia varied between ≥0.4 and ≥0.9 mmol/L during the last 5 weeks prepartum. For goats in this research BHB values were consistent at around 0.4 mmol/L (±0.01 mmol/L) in both sampling periods.…”

Section: Discussionmentioning

confidence: 99%

Blood metabolites of extensively reared Croatian multi-coloured goats during early lactation and early gravidity

et al. 2017

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Goat breeding has been one of the most important activities of the rural population in Dalmatian Zagora for decades. The predominant breed was, and still is, the Croatian coloured goat, bred almost exclusively for meat. Extensive farming is currently a dominant farming system with some flocks being bred under organic conditions. In this research we monitored an organic flock in the area of Dinara Mountain during one season. Blood samples were randomly collected from 80 does on two occasions: in March in their early lactation and in October in their early gravidity, and were analysed for the most common biochemical parameters (glucose, urea, bilirubin, total proteins, albumin, triglycerides, cholesterol, aspartate aminotransferase (AST), gamma-glutamyl transferase (GGT) and two parameters of metabolic profile (non-esterified fatty acids (NEFA), β-hydroxybutyrate (BHB)). Significant differences were found between all of the parameters, except BHB and AST. The obtained results from multi-coloured goats may represent a contribution to a better understanding of metabolic processes during early lactation and early gravidity in indigenous Croatian goats.

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“…A recent study [13] tried to identify risk factors for developing PT in goats during the last month of gestation based on their blood BHBA values.…”

Section: Discussionmentioning

confidence: 99%

Usefulness of clinical observations and blood chemistry values for predicting clinical outcomes in dairy goats with pregnancy toxaemia

et al. 2016

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BackgroundPregnancy toxaemia (PT) is a disease that affects pregnant goats during their last month of gestation and is characterized by a high case fatality rate. This study involved 32 does maintained on a commercial dairy goat farm that were diagnosed with PT. A physical examination was performed on and haematology parameters obtained from each doe, at the time of diagnosis. The data from the 24 PT goats that died was compared with the corresponding data from the 8 PT goats that survived.ResultsPolypnea, swollen limbs, anorexia with absence of ruminal motility, recumbency, nervous signs and drooping ears were the most frequently observed clinical manifestations. Nineteen out of 21 recumbent goats died. Sixteen out of 17 goats with anorexia and absence of ruminal motility died. Mean beta-hydroxybutyric acid (BHBA) values in the goats that died were not significantly different from those in goats that survived. The blood values for pH and pCO2 (p < 0.005) as well as for HCO3 −, BE and K+ (p < 0.001) were significantly lower in the goats that died than in those that survived.ConclusionsThe clinical signs most indicative of a poor prognosis are anorexia with absence of ruminal motility and recumbency. Among the blood parameters to be considered, hypokalaemia and metabolic acidosis are the most relevant. Goats with PT have a high mortality and their condition can deteriorate very fast. Based on the authors’s experience, a good strategy to minimize the economic losses caused by PT is to focus on the offspring survival rate since an early decision (induction of kidding or caesarian surgery) can increase the number of alive kids.

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Definition of prepartum hyperketonemia in dairy goats

Cited by 30 publications

References 28 publications

Haemato-biochemical profile and acid–base status of Croatian spotted goats of different ages

Haemato-biochemical profile and acid–base status of Croatian spotted goats of different ages

Blood metabolites of extensively reared Croatian multi-coloured goats during early lactation and early gravidity

Usefulness of clinical observations and blood chemistry values for predicting clinical outcomes in dairy goats with pregnancy toxaemia

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