Deficits in the left inferior longitudinal fasciculus results in impairments in object naming

Shinoura, Nobusada; Suzuki, Yuichi; Tsukada, Masanobu; Yoshida, Mizuho; Yamada, Ryuzo; Tabei, Yusuke; Koizumi, Tomoyuki; Yagi, Kazuo

doi:10.1080/13554790903329174

Cited by 37 publications

(40 citation statements)

References 20 publications

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“…Even if not yet validated on a large number of specimens, this bundle may represent the key of the visual limbic pathway that subserves emotional, learning, and memory functions that are modalityspecific to vision [18]. Several DTI studies reported correlations between reduced FA in some portions of the ILF and impairments of higher visuo-perceptual functions [76] including object and picture naming [57,81], dyslexia [28,74,84], and alexia [32]. Moreover, according to Catani et al [14] the role of this ventral bundle is even more complex.…”

Section: Li-am Bundlementioning

confidence: 97%

New insights in the limbic modulation of visual inputs: The role of the inferior longitudinal fasciculus and the Li-Am bundle

Latini¹

2014

Neurosurg Rev

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Recent anatomical and DTI data demonstrated new aspects in the subcortical occipito-temporal connections. Although a direct (inferior longitudinal fasciculus, ILF) pathway has been previously described, its fine description is still matter of debate. Moreover, a fast and direct subcortical connection between the limbic system and the occipital lobe has been previously recognized in many functional studies but it still remains poorly documented by anatomical images. We provided for the first time an extensive and detailed anatomical description of the ILF subcortical segmentation. We dissected four human hemispheres with modified Klingler's technique, from the basal to the lateral occipito-temporal surface in the two steps, tracking the ILF fibers until their cortical termination. Pictures of this direct temporo-occipital pathway are discussed in the light of recent literature regarding anatomy and functions of occipito-temporal areas. The dissection confirmed the classical originating branches of ILF and allowed a fine description of two main subcomponent of this bundle, both characterized by separate hierarchical distribution: a dorsal ILF and a ventral ILF. Moreover, a direct pathway between lingual cortex and amygdala, not previously demonstrated, is here described with anatomical images. Even if preliminary in results, this is the first fine description of ILF's subcomponents. The complex but clearly segregated organization of the fibers of this bundle (dILF and vILF) supports different level of functions mediated by visual recognition. Moreover, the newly described direct pathway from lingual to amygdala (Li-Am), seems involved in the limbic modulation of visual processing, so it may support physiological conditions the crucial role of this connection in human social cognition. In pathological conditions, on the other hand, this may be one of the hyperactivated pathways in temporo-occipital epileptic and nonepileptic syndromes.

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Section: Li-am Bundlementioning

confidence: 97%

New insights in the limbic modulation of visual inputs: The role of the inferior longitudinal fasciculus and the Li-Am bundle

Latini¹

2014

Neurosurg Rev

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“…Studies using EEG and MEG have identified the timing of ATL involvement within the network, revealing recurrent interactions between the left ATL, a putative integrative hub, and more posterior regions involved in perceptual processes (Clarke et al, 2011; van Ackeren MJ and Rueschemeyer SA; Clarke et al, 2014). It is also informative that stimulation of long-range fiber tracts connecting the ATL and posterior and frontal regions has been shown to disrupt semantic knowledge retrieval (Shinoura et al, 2010; Papagno et al, 2011; Von der Heide, 2013). …”

Section: Introductionmentioning

confidence: 99%

“…The first is found in the rostral ATL including the temporal pole, and consists of long-range association fiber tract terminations (Catani et al, 2003; Kier et al, 2004; Martino et al, 2010; Martino et al, 2011; Axer et al, 2013). Two relevant tracts are the inferior longitudinal fasciculus, with connections to posterior occipito-temporal visual association cortices; and the uncinate fasciculus, with connections to orbital and polar frontal cortices (Shinoura et al, 2010; Martino et al, 2011; Dick and Tremblay, 2012; Von der Heide, 2013; Lam et al, 2014). Both tracts have been implicated in name retrieval, with some evidence for their differential involvement depending on conceptual category and/or level of specificity (Shinoura et al, 2010; Papagno et al, 2011; Von der Heide, 2013).…”

Section: Introductionmentioning

confidence: 99%

“…Two relevant tracts are the inferior longitudinal fasciculus, with connections to posterior occipito-temporal visual association cortices; and the uncinate fasciculus, with connections to orbital and polar frontal cortices (Shinoura et al, 2010; Martino et al, 2011; Dick and Tremblay, 2012; Von der Heide, 2013; Lam et al, 2014). Both tracts have been implicated in name retrieval, with some evidence for their differential involvement depending on conceptual category and/or level of specificity (Shinoura et al, 2010; Papagno et al, 2011; Von der Heide, 2013). ATL subdivisions targeted by the inferior longitudinal fasciculus and the uncinate fasciculus can reasonably be hypothesized to support semantic access in which visual perceptual properties and social/emotional properties, respectively, are key constituents.…”

Section: Introductionmentioning

confidence: 99%

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Segregation of anterior temporal regions critical for retrieving names of unique and non-unique entities reflects underlying long-range connectivity

Mehta

Inoue

Rudrauf

et al. 2016

Cortex

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Lesion-deficit studies support the hypothesis that the left anterior temporal lobe (ATL) plays a critical role in retrieving names of concrete entities. They further suggest that different regions of the left ATL process different conceptual categories. Here we test the specificity of these relationships and whether the anatomical segregation is related to the underlying organization of white matter connections. We reanalyzed data from a previous lesion study of naming and recognition across five categories of concrete entities. In voxelwise logistic regressions of lesion-deficit associations, we formally incorporated measures of disconnection of long-range association fiber tracts (FTs) and covaried for recognition and non-category specific naming deficits. We also performed fiber tractwise analyses to assess whether damage to specific FTs was preferentially associated with category-selective naming deficits. Damage to the basolateral ATL was associated with naming deficits for both unique (famous faces) and non-unique entities, whereas the damage to the temporal pole was associated with naming deficits for unique entities only. This segregation pattern remained after accounting for comorbid recognition deficits or naming deficits in other categories. The tractwise analyses showed that damage to the uncinate fasciculus was associated with naming impairments for unique entities, while damage to the inferior longitudinal fasciculus was associated with naming impairments for non-unique entities. Covarying for FT transection in voxelwise analyses rendered the cortical association for unique entities more focal. These results are consistent with the partial segregation of brain system support for name retrieval of unique and non-unique entities at both the level of cortical components and underlying white matter fiber bundles. Our study reconciles theoretic accounts of the functional organization of the left ATL by revealing both category-related processing and semantic hub sectors.

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“…In some cases, deficits in the left ILF resulted in impairments in object naming. 15) However, in another case, the ILF was not indispensable for language semantic pathways because subcortical stimulation never elicited any language disturbances when performed at the level of the ILF. 8) We recommend individual mapping under the awake condition for glioma patients, because the language areas might be located in various and unexpected regions, including the ITC.…”

Section: Discussionmentioning

confidence: 99%

Language Areas Involving the Inferior Temporal Cortex on Intraoperative Mapping in a Bilingual Patient With Glioblastoma

Kin¹,

Ishikawa²,

Takano³

et al. 2013

Neurol. Med. Chir.(Tokyo)

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Fig. 1 Upper row: T 1 -weighted magnetic resonance (MR) images with gadolinium showing a small ring-enhanced mass in the left superior temporal lobe. Lower row: T 2 -weighted MR images revealing the presence of a hyperintense area in the temporal lobe measuring 6 cm in maximal diameter. 256 CASE REPORT AbstractA 40-year-old bilingual man underwent removal of glioblastoma multiforme with intraoperative language mapping, mainly using the picture-naming and auditory responsive-naming tasks under cortical stimulation. Multiple language areas were identified, including one located in the middle of the inferior temporal cortex (ITC). Individual mapping for glioma patients must be performed because language areas might be located in various and unexpected regions, including the ITC.

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Deficits in the left inferior longitudinal fasciculus results in impairments in object naming

Cited by 37 publications

References 20 publications

New insights in the limbic modulation of visual inputs: The role of the inferior longitudinal fasciculus and the Li-Am bundle

New insights in the limbic modulation of visual inputs: The role of the inferior longitudinal fasciculus and the Li-Am bundle

Segregation of anterior temporal regions critical for retrieving names of unique and non-unique entities reflects underlying long-range connectivity

Language Areas Involving the Inferior Temporal Cortex on Intraoperative Mapping in a Bilingual Patient With Glioblastoma

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