Deficiency of serum concentration of 25-hydroxyvitamin D correlates with severity of disease in chronic plaque psoriasis

Ricceri, Federica; Pescitelli, Leonardo; Tripo, Lara; Prignano, Francesca

doi:10.1016/j.jaad.2012.10.051

Cited by 49 publications

(44 citation statements)

References 4 publications

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“…In a study by Gisondi, the participants with psoriasis presented a 2.5 times greater risk of having 25-hydroxyvitamin D deficiency than those without the disease (19). Ricceri et al found a prevalence of 68% of vitamin D deficiency and 97% of insufficiency in the patients with psoriasis studied, while the percentages found in the control group were 10% of deficiency and approximately 53% of insufficiency of 25(OH)D (20).…”

Section: Discussionmentioning

confidence: 98%

Vitamin D status in patients with psoriasis

Pavlov

Ivanova

Gerova

2016

SSM

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Section: Discussionmentioning

confidence: 98%

Vitamin D status in patients with psoriasis

Pavlov

Ivanova

Gerova

2016

SSM

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“…Several case-control studies have shown significant lower levels of serum 25(OH)D in psoriatic patients compared to controls and reported an inverse correlation between serum 25(OH)D and the severity of the disease [62,63,64,65,66]. However, in a population-based screening, Wilson [67] showed that vitamin D deficiency is not common in psoriatic patients and that there is no significant difference in serum 25(OH)D levels in subjects with or without psoriasis.…”

Section: Role Of Vitamin D In Certain Inflammatory Skin Diseasesmentioning

confidence: 99%

Vitamin D and the Pathophysiology of Inflammatory Skin Diseases

Umar

Sastry

Ali

et al. 2018

Skin Pharmacol Physiol

142

135

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Background: Vitamin D is a secosteroid, which was initially known for its skeletal role; however, in recent years, its functions in different organs have been increasingly recognized. In this review, we will provide an overview of vitamin D functions in the skin physiology with specific focus on its role in certain inflammatory skin conditions such as psoriasis and atopic dermatitis. Methods: A comprehensive literature search was carried out in PubMed and Google Scholar databases using keywords like “vitamin D,” “skin,” “atopic dermatitis,” and “psoriasis.” Only articles published in English and related to the study topic were included in this review. Results: Vitamin D is integrally connected to the skin for its synthesis, metabolism, and activity. It regulates many physiological processes in the skin ranging from cellular proliferation, differentiation, and apoptosis to barrier maintenance and immune functions. Vitamin D deficiency is associated with the risk of psoriasis and atopic dermatitis, and several clinical/observational studies have suggested the beneficial effect of vitamin D in the therapy of these 2 inflammatory skin disorders. Conclusions: Vitamin D exerts a pleiotropic effect in the skin and could be an important therapeutic option for psoriasis and atopic dermatitis.

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“…Furthermore, a case-control studybyRicceri et al [31] conducted on 68 patients with chronic plaque psoriasis and 60 healthy controls demonstrated a statistically significant inverse linear correlation between patient's vitamin D levels and their Psoriasis Area Severity Index (PASI) scores. Also Mok et al [32] in their study on SLE patients found that 25(OH) D level correlated inversely and significantly with SLE activity.…”

mentioning

confidence: 99%

Low Serum Vitamin D Levels in Egyptian Adults With Chronic Primary Immune Thrombocytopenia: A Single Center Study.

Soliman¹,

Elsalakawy²,

Saeed³

et al. 2017

IJAR

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Objectives:Immune thrombocytopenia (ITP) is a disorder characterized by immune-mediated accelerated platelet destruction and suppressed platelet production. Low vitamin D levels have been found in several autoimmune diseases, such as rheumatoid arthritis, SLE. The mechanisms underlying the link between vitamin D with autoimmunity are not completely understood. No currently available studies about vitamin D status in primary ITP patients. Aim: To evaluate vitamin D levels in patients with primary chronic ITP and compare these levels with normal control subjects and patients with thrombocytopenia due to other non-immune causes Methods: The study included 80 adult subjects, 40 ITP patients (They were segregated into 20 responders and 20 non-responders), 20 cases of thrombocytopenia due to non ITP causes and 20 healthy control subjects. Measurement of serum 25monohydroxyvitamin D was done with ELISA. Results: Vitamin D levels were significantly lower in patients with ITP (range=2-40ng/ml; mean±SD=17.29±10.96 ng/ml) and thrombocytopenia due to non-ITP causes (range=10-40ng/ml; mean±SD=21.05±8.31 ng/ml) in comparison to normal healthy controls (range = 10-65 ng/ml; mean±SD=36.70±16

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Deficiency of serum concentration of 25-hydroxyvitamin D correlates with severity of disease in chronic plaque psoriasis

Cited by 49 publications

References 4 publications

Vitamin D status in patients with psoriasis

Vitamin D status in patients with psoriasis

Vitamin D and the Pathophysiology of Inflammatory Skin Diseases

Low Serum Vitamin D Levels in Egyptian Adults With Chronic Primary Immune Thrombocytopenia: A Single Center Study.

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