Vitamin D and the Pathophysiology of Inflammatory Skin Diseases

Umar, Meenakshi; Sastry, Konduru S.; Ali, Fatima; Al-Khulaifi, Moza; Wang, Ena; Chouchane, Aouatef Ismail

doi:10.1159/000485132

Cited by 128 publications

(122 citation statements)

References 141 publications

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“…It serves this purpose due to its complex anatomy, consisting of lipids and cells in a “brick-and-mortar” fashion. The anucleated cells of the SC are called corneocytes, which are arranged in 18–20 layers in the form of stacks, and these layers are separated by lipid lamellae [4-6]. …”

Section: Introductionmentioning

confidence: 99%

Quantitative Analysis of Free Amino Acids and Urea Derived from Isolated Corneocytes of Healthy Young, Healthy Aged, and Diseased Skin

Hussain¹,

Ziegler²,

Hause³

et al. 2019

Skin Pharmacol Physiol

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Background/Aims: Free amino acids (FAAs) and urea, present inside the corneocytes, can be important indicators of skin condition. However, due to the lack of a standard extraction protocol for FAAs from corneocytes, conflicting research results have been reported. Therefore, the purpose of this study was (1) to standardize the extraction protocol and (2) to investigate FAA profiles in healthy young and healthy old volunteers, as well as in psoriasis and atopic dermatitis patients. Methods: Skin samples were collected from four groups (healthy young, healthy old, and psoriasis and atopic dermatitis patients) with 5 volunteers per group. Corneocytes were isolated and examined microscopically. FAAs and urea were extracted from the isolated corneocytes, and their amounts were quantified using LC-ESI/MS/MS (after derivatization with Fmoc-Cl) and colorimetric methods, respectively. Results: The micrographs of the corneocytes showed no morphological features attributable to age or disease conditions. The highest and lowest concentrations of total FAAs and urea were observed in the healthy old group and the healthy young group, respectively. Unlike the other FAAs and urea, citrulline was found at a higher level in the healthy young group than in the disease groups. Conclusion: This study suggests that the levels of FAAs and urea in the skin are affected by age and skin conditions (healthy/diseased). However, further studies are needed to show the effects of different skin conditions on the levels of FAAs and urea.

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Section: Introductionmentioning

confidence: 99%

Quantitative Analysis of Free Amino Acids and Urea Derived from Isolated Corneocytes of Healthy Young, Healthy Aged, and Diseased Skin

Hussain¹,

Ziegler²,

Hause³

et al. 2019

Skin Pharmacol Physiol

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“…In addition, VD stimulates the expression of antimicrobial peptides in the skin, modulates the expression of different inflammatory cytokines, leading to reduced T‐cell activation, and may have a role in epidermal differentiation and skin barrier. All of these functions support its role in the pathophysiology of AD . While low serum levels of VD have been linked to AD severity in certain populations, these findings have not been replicated in others .…”

Section: Introductionmentioning

confidence: 91%

The association between atopic dermatitis and serum 25‐hydroxyvitamin D in children: Influence of sun exposure, diet, and atopy features—A cross‐sectional study

Sanmartín¹,

Pardos

Doste³

et al. 2020

Pediatric Dermatology

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Background Previous studies have linked low serum vitamin D (VD) or 25‐hydroxyvitamin D (25(OH)D) levels with increased severity of atopic dermatitis (AD) in children. Objective To investigate the association between serum VD (25(OH)D) levels and AD and AD severity, considering the influence of diet and sun exposure. Methods We performed a prospective cross‐sectional study of healthy controls and children diagnosed with AD. Participants were recruited between January 2011 and December 2012, and the following parameters were assessed: age, sex, body mass index (BMI), AD severity, Fitzpatrick skin type, asthma and rhinitis history, dietary VD intake, daily potential sun‐induced VD production, sunscreen use, 25(OH)D and IgE serum levels, and results of the ImmunoCAP Phadiatop Infant test. Results The study population consisted of 105 healthy controls and 134 AD patients. Serum 25(OH)D levels were significantly lower in moderate and severe AD than in mild AD, although this association was only significant for patients with light Fitzpatrick skin type (mean(SD) 36.7 (11.9) ng/mL; moderate 28.8 [11.5] ng/mL; and severe 27.6 [12.1] ng/mL, P = .045). Logistic regression analysis revealed a positive association between severe AD and both positive ImmunoCAP Phadiatop test and BMI. Conclusion Our data support an association between VD deficiency and AD severity only in patients with light complexion.

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“…Beim Menschen ist die Hauptquelle von Vitamin D jedoch die kutane Synthese unter Mitwirkung von Sonnenlicht [1] (Abb. 1).…”

Section: Transfer In Die Praxis Von Dr Sandra Philipp (Berlin)unclassified

Vitamin D als therapeutische Option bei Psoriasis und atopischer Dermatitis?

Philipp¹

2018

Kompass Dermatol

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Background: Vitamin D is a secosteroid, which was initially known for its skeletal role; however, in recent years, its functions in different organs have been increasingly recognized. In this review, we will provide an overview of vitamin D functions in the skin physiology with specific focus on its role in certain inflammatory skin conditions such as psoriasis and atopic dermatitis. Methods: A comprehensive literature search was carried out in PubMed and Google Scholar databases using keywords like “vitamin D,” “skin,” “atopic dermatitis,” and “psoriasis.” Only articles published in English and related to the study topic were included in this review. Results: Vitamin D is integrally connected to the skin for its synthesis, metabolism, and activity. It regulates many physiological processes in the skin ranging from cellular proliferation, differentiation, and apoptosis to barrier maintenance and immune functions. Vitamin D deficiency is associated with the risk of psoriasis and atopic dermatitis, and several clinical/observational studies have suggested the beneficial effect of vitamin D in the therapy of these 2 inflammatory skin disorders. Conclusions: Vitamin D exerts a pleiotropic effect in the skin and could be an important therapeutic option for psoriasis and atopic dermatitis.

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Vitamin D and the Pathophysiology of Inflammatory Skin Diseases

Cited by 128 publications

References 141 publications

Quantitative Analysis of Free Amino Acids and Urea Derived from Isolated Corneocytes of Healthy Young, Healthy Aged, and Diseased Skin

Quantitative Analysis of Free Amino Acids and Urea Derived from Isolated Corneocytes of Healthy Young, Healthy Aged, and Diseased Skin

The association between atopic dermatitis and serum 25‐hydroxyvitamin D in children: Influence of sun exposure, diet, and atopy features—A cross‐sectional study

Vitamin D als therapeutische Option bei Psoriasis und atopischer Dermatitis?

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