The association between atopic dermatitis and serum 25‐hydroxyvitamin D in children: Influence of sun exposure, diet, and atopy features—A cross‐sectional study

Sanmartín, Rosalia; Pardos, Carlos; Doste, Divina; Aguilera, José; Alijarde, Roberto; Agón‐Banzo, Pedro Jesús; García‐Malinis, Ana Julia; Puzo, José; Hernández‐Martín, Ángela; Gilaberte, Yolanda

doi:10.1111/pde.14049

Cited by 10 publications

(11 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Most of the studies showed serum 25(OH)D was significantly lower in AD than HC. Of the 14 studies, only Sanmartin et al [13] and Di Filippo et al [25] showed higher 25(OH)D for AD compared with HC, but these differences were not significant. Three sub-analyses were conducted for latitude, geographical continent, and quality of study (Supplementary Figs.…”

Section: Serum Vitamin D In Atopic Dermatitis and Healthy Controlsmentioning

confidence: 89%

Effect of Vitamin D Serum Levels and Supplementation on Atopic Dermatitis: A Systematic Review and Meta-analysis

Ng¹,

Yew

2022

Am J Clin Dermatol

View full text Add to dashboard Cite

Background Previous studies have shown that serum 25-hydroxyvitamin D (25(OH)D) may be associated with atopic dermatitis (AD), and that vitamin D (VD) supplementation may decrease AD severity. Objective The aim of this study was to investigate the association between serum 25(OH)D level and AD, and the effect of VD supplementation on AD severity, while providing stratified analyses based on latitude and region. Methods A systematic review was performed on all published studies in MEDLINE, Embase, and Cochrane Library databases that analyzed effects of serum 25(OH)D and VD supplementation on AD. Results This systematic review and meta-analysis includes 20 studies with 1882 cases of AD. We found significantly lower 25(OH)D levels in AD patients compared with healthy controls (HC) (p < 0.001), significantly lower 25(OH)D levels in severe AD compared with both mild and moderate AD (p < 0.001), and VD supplementation improved AD symptoms (p < 0.001). Limitations Factors like seasonal and environmental changes, sunlight exposure, and cultural practices may confound the relationship between serum 25(OH)D and AD severity. There are limited randomized controlled trials that assess this association. Conclusion Overall, lower serum 25(OH)D is associated with more severe AD, and VD supplementation may help lower AD severity. Further research is needed to confirm the presence and direction of causality of the relationship between VD and AD pathogenesis. Key PointsAtopic dermatitis (AD) patients had significantly lower 25-hydroxyvitamin D (25(OH)D) levels compared with healthy controls. Patients with severe disease had lower 25(OH)D levels than patients with mild and moderate disease. AD symptoms improved after vitamin D (VD) supplementation.Further research on efficacy and optimal dosage of VD supplementation in AD treatment is required.

show abstract

Section: Serum Vitamin D In Atopic Dermatitis and Healthy Controlsmentioning

confidence: 89%

Effect of Vitamin D Serum Levels and Supplementation on Atopic Dermatitis: A Systematic Review and Meta-analysis

Ng¹,

Yew

2022

Am J Clin Dermatol

View full text Add to dashboard Cite

show abstract

“…Vitamin D (VitD) can be formed in the human skin through sunlight exposure or obtained from dietary intake [ 5 , 6 , 7 ]. It is essential for the maintenance of bone health [ 6 , 8 ], regulating calcium and phosphate metabolism [ 6 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Serum 25-Hydroxyvitamin D Concentrations and Atopic Dermatitis in Early Childhood: Findings from the Japan Environment and Children’s Study

et al. 2021

View full text Add to dashboard Cite

Vitamin D (VitD) may affect immune system modulation and result in the development of atopic dermatitis (AD). However, published findings have remained controversial. We investigated the association between early-life 25-hydroxyvitamin D (25(OH)D) levels and AD risk at childhood with a birth cohort. The data were obtained from “the Japan Environment and Children’s Study (JECS)” and “the Sub-Cohort study of JECS” performed with children aged 2 years. “Liquid chromatography-tandem mass spectrometry” was used to measure VitD. The information on AD was obtained from parents’ answers to a questionnaire when their children were aged 3 years. In order to explain the seasonal effects on VitD levels, a deseasonalized continuous variable was further calculated. The logistic regression models were fitted to evaluate the effect of VitD on childhood AD. The study included 4378 children with complete data on VitD and AD. The results from models indicated that low VitD at 2 years was not a risk factor for the development of AD at 3 years, after adjusting for potential confounders. Moreover, there was no U-shape relationship between deseasonalized VitD and childhood AD. Overall, early-life 25(OH)D levels were not link to the increased risk of developing childhood AD.

show abstract

“…Следует также отметить, что группы детей с АтД и здоровых сверстников были сопоставимы по периодам включения в исследования (> 40% участников были включены в зимние месяцы). Вместе с тем, по некоторым данным, концентрация 25(ОН)D у детей с АтД в летний сезон выше, чем у здоровых детей, предположительно, за счет большего пребывания на солнце [26]. В связи с этим не исключено, что при формировании репрезентативной выборки за счет включения в исследование пациентов в летний период различия в концентрации 25(ОН)D не были бы обнаружены.…”

Section: ограничения исследованияunclassified

“…с АтД (18,58 ± 0,29 нг/мл) по сравнению с контрольной группой (19,20 ± 0,15 нг/мл), p = 0,02 [27]. При этом в некоторых исследованиях связь между концентрацией 25(ОН)D и АтД не была подтверждена как у детей с АтД [13,14,26], так и у взрослых с АтД [28,29]. В нашем исследовании было установлено, что более низкая концентрация 25(ОН)D ассоциирована с более тяжелым течением АтД.…”

Section: интерпретация результатов исследованияunclassified

Association Between 25(ОН)D Concentration and Atopic Dermatitis and Its Severity Children Aged from 3 to 6 Years: Cross Sectional Study

Кашинская

Шахова

2021

Vopr. sovr. pediatr.

View full text Add to dashboard Cite

Background. The association between the vitamin D provision for children and the atopic dermatitis (AD) development and severity is not clearly determined.Objective. The aim of the study was to compare 25(OH)D serum concentration in children with AD and in healthy peers with association analysis of 25(OH)D with disease severity and allergen sensibilization.Methods. The study included children aged from 3 to 6 years with AD and their healthy peers. Vitamin D provision was estimated via 25(OH)D serum concentration determined by chemiluminescent microparticle immunoassay. Vitamin D deficiency was established at 25(OH)D concentration 20 ng/ml, insufficiency — 21–29 ng/ml. Sensibilization to airborne (Dermatophagoides pteronyssinus, Dermatophagoides farinae, cat epithelium and dandruff) and food (cow's milk and chicken egg proteins) allergens was determined by IgE concentration revealed via immunofluorescence.Results. The 25(OH)D serum concentration in children with AD (n = 106) was lower than in their healthy peers (n = 40), median (interquartile range) — 26.5 ng/ml (19.0–35.3) and 32.4 ng/ml (27.9–37.5) respectively (p = 0.012). Meanwhile, vitamin D insufficiency/deficiency according to 25(OH)D concentration was revealed in more than half patients (58%) with AD and in every third child (37%) from control group (OR — 3.5, 95% CI — 1.6–7.5). It was also revealed that 25(OH)D concentration was lower in patients with moderate course of AD (in comparison to mild) as well as in children sensibilized to airborne and/or food allergens.Conclusion. The vitamin D provision in preschool children is associated with AD, its severity and the presence of sensibilization to airborne and/or food allergens.

show abstract

The association between atopic dermatitis and serum 25‐hydroxyvitamin D in children: Influence of sun exposure, diet, and atopy features—A cross‐sectional study

Cited by 10 publications

References 39 publications

Effect of Vitamin D Serum Levels and Supplementation on Atopic Dermatitis: A Systematic Review and Meta-analysis

Effect of Vitamin D Serum Levels and Supplementation on Atopic Dermatitis: A Systematic Review and Meta-analysis

Serum 25-Hydroxyvitamin D Concentrations and Atopic Dermatitis in Early Childhood: Findings from the Japan Environment and Children’s Study

Association Between 25(ОН)D Concentration and Atopic Dermatitis and Its Severity Children Aged from 3 to 6 Years: Cross Sectional Study

Contact Info

Product

Resources

About