Objectives:Immune thrombocytopenia (ITP) is a disorder characterized by immune-mediated accelerated platelet destruction and suppressed platelet production. Low vitamin D levels have been found in several autoimmune diseases, such as rheumatoid arthritis, SLE. The mechanisms underlying the link between vitamin D with autoimmunity are not completely understood. No currently available studies about vitamin D status in primary ITP patients. Aim: To evaluate vitamin D levels in patients with primary chronic ITP and compare these levels with normal control subjects and patients with thrombocytopenia due to other non-immune causes Methods: The study included 80 adult subjects, 40 ITP patients (They were segregated into 20 responders and 20 non-responders), 20 cases of thrombocytopenia due to non ITP causes and 20 healthy control subjects. Measurement of serum 25monohydroxyvitamin D was done with ELISA. Results: Vitamin D levels were significantly lower in patients with ITP (range=2-40ng/ml; mean±SD=17.29±10.96 ng/ml) and thrombocytopenia due to non-ITP causes (range=10-40ng/ml; mean±SD=21.05±8.31 ng/ml) in comparison to normal healthy controls (range = 10-65 ng/ml; mean±SD=36.70±16
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