Deficiência auditiva na toxoplasmose congênita detectada pela triagem neonatal

Abstract

Congeni tal toxoplasmosis may cause sensorineural deficit in up to 20% of the patients and proper treatment in the first year improves prognosis. In Brazil, this infection's impact on hearing impairment is unknown. Aim: To evaluate hearing of newborns with congenital toxoplasmosis identified by the newborn screening service. Method: This prospective study analyzed children with congenital toxoplasmosis identified by newborn screening (IgM anti-T.gondii) in Belo Horizonte during 2003/2004. The presence of IgM and/or IgA in the first 6 months or IgG at 12 months-of age in serology was used as case definition. Hearing tests were carried out at the time of diagnosis and 12 months later, including behavioral audiometry, evoked otoacoustic emission and brainstem evoked responses audiometry. Results: Among 30.808 screened children (97% of live births), 20 had congenital toxoplasmosis, 15 (75%) were asymptomatic at birth. Nineteen children were evaluated by hearing tests. Four had sensorineural impairment (21.1%). One child had other risk factors for hearing impairment; the other three had no other risk factors but toxoplasmosis. Two properly children treated still had hearing loss, in disagreement with current literature. Conclusion: Results suggest that congenital toxoplasmosis, common in Brazil, is a risk factor for hearing impairment and its impact on hearing loss deserves further studies.

Alterações auditivas em crianças expostas à toxoplasmose durante a gestação

“…The occurrence of retrocochlear auditory disorders in 20.8% of the SG children in the present study is similar to that found in the literature, between 21.1 and 35.5% 4,11,25 . However, it differed from other studies in which the prevalence found was significantly lower or even zero 14,23,26,27 .…”

“…Studies have found a prevalence of congenital toxoplasmosis between 0.6-1.3/1000 live births in different regions of Brazil [4][5][6] . It has been suggested that the chance of transmission of toxoplasmosis from mother to fetus ranges from 18.5 to 23% 6,7 .…”

“…Lorena Carvalho Cavalcanti Lagreca (2) Natália Oliveira de Jesus (1) Cristiana Porchia Corvaro (3) Maria Aparecida Gadiani Ferrarini (4) Ana Isabel Melo Pereira Monteiro (4) Marisa Frasson de Azevedo (5) …”

Potencial Evocado Auditivo de Tronco Encefálico: padrão de respostas de lactentes termos e prematuros

“…Lactating infants according to values (mean, standard deviation and median in milliseconds -ms) and a comparison of absolute wave I, III and V and interpeaks I-III, III-V and I-V latencies at 80 dBHL, and the absolute wave V latency at 60, 40 Table 4 shows the wave I, III and V absolute and interpeak latencies at 80 dBHL and wave V latency at 60, 40 and 20 dBHL in term and premature infants, and the comparison between groups. Statistically significant differences were found in a comparison of absolute latencies for waves I, III and V at 80 dB between term and premature infants; higher values were found in premature infants at all intensities compared to term infants.…”

Prevalência de alterações auditivas em crianças de risco

“…Patients with this disease were referred for audiological investigation, the results of which showed that 21.1% of these infants had sensorineural hearing loss and 10.5% had conduction hearing loss. 22 Hearing loss in CMV infection is generally progressive. The infant with CMV infection in this study acquired the disease after a blood transfusion; statistical significance, however, was not attained.…”