Defective
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            -Arginine–Nitric Oxide Pathway in Offspring of Essential Hypertensive Patients

Taddei, Stefano; Virdis, Agostino; Mattei, Paola; Ghiadoni, Lorenzo; Sudano, Isabella; Salvetti, Antonio

doi:10.1161/01.cir.94.6.1298

Cited by 281 publications

(190 citation statements)

References 36 publications

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“…nitrites and nitrates and the NO inactivating factor namely plasma hemoglobin, present freely in plasma. Essential hypertension is characterized by impaired endotheliumdependent vasodilation [29]. In our study nitrite and nitrate values were similar in controls of both age groups slightly higher in the higher age group controls (Group II).…”

Section: Resultssupporting

confidence: 59%

Assessment of Endothelial Dysfunction in Health and Disease; Using Various Parameters

Jalali

Phadke

2011

Ind J Clin Biochem

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Conditions like hypertension, atherosclerosis and diabetes are known to be the result of endothelial dysfunction which could begin early in the life of an individual. The markers of endothelial dysfunction studied in the present work are plasma hemoglobin, serum high sensitivity C-reactive protein (hsCRP) and plasma nitrite and nitrate. We studied the onset of endothelial dysfunction with increase in age as well as in disease condition like newly detected hypertensives and of hypertensive diabetic patients. The mean plasma hemoglobin and hsCRP values were found to increase with age. hsCRP and plasma hemoglobin levels were significantly higher in patient groups as compared to aged-matched controls. On the other hand nitrate and nitrite was significantly higher in patients who suffered from both diabetes and hypertension together and nitrate values were significantly lower in patients who suffered from hypertensive alone. Plasma hemoglobin and hsCRP are associated with endothelial dysfunction and increases both with age as well as in disease condition.

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Section: Resultssupporting

confidence: 59%

Assessment of Endothelial Dysfunction in Health and Disease; Using Various Parameters

Jalali

Phadke

2011

Ind J Clin Biochem

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“…Several lines of evidence have suggested that endothelial function is impaired as blood pressure increases and that the degree of dysfunction is related to the magnitude of blood pressure elevation, 64,65 indicating that endothelial dysfunction is a consequence of hypertension. In contrast, Taddei et al 66 recently presented interesting results showing that young offspring of essential hypertensive patients who have a family history of hypertension are characterized by a reduced response to acetylcholine linked to a defect in the NO pathway, suggesting that endothelial dysfunction may be a cause of hypertension. There is still insufficient evidence for a conclusion to be reached.…”

Section: Endothelial Dysfunction and Hypertensionmentioning

confidence: 94%

Endothelial dysfunction and hypertension in aging

2012

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Hypertension is one of the common diseases in the elderly. The prevalence of hypertension markedly increases with advancing age. Both aging and hypertension have a critical role in cardiovascular and cerebrovascular complications. Although aging and hypertension, either independently or collectively, impair endothelial function, aging and hypertension may have similar cascades for the pathogenesis and development of endothelial dysfunction. Nitric oxide (NO) has an important role in regulation of vascular tone. Decrease in NO bioavailability by endothelial dysfunction would lead to elevation of blood pressure. An imbalance of reduced production of NO or increased production of reactive oxygen species, mainly superoxide, may promote endothelial dysfunction. One possible mechanism by which the prevalence of hypertension is increased in relation to aging may be advancing endothelial dysfunction associated with aging through an increase in oxidative stress. In addition, endothelial cell senescence is also involved in aging-related endothelial dysfunction. In this review, we focus on recent findings and interactions between endothelial function, oxidative stress and hypertension in aging.

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“…They demonstrated attenuated responses to endothelium depen-dent vasodilators such as acetylcholine but preserved responses to endothelium independent vasodilators such as sodium nitroprusside in hypertensive patients 31,32 and even in their normotensive offspring. 33 However, not all human trials have confirmed these abnormalities of vascular NO bioactivity in hypertension. Cockroft et al 34 studied endothelial function in a larger population of essential hypertensives than previous trials and found vasodilator responses to muscarinic agonists and nitroprusside to be similar to those in normotensive controls.…”

Section: Endothelial No and Hypertensionmentioning

confidence: 99%

Nitric oxide and hypertension: not just an endothelium derived relaxing factor!

Chowdhary

Townend

2001

J Hum Hypertens

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The importance of endothelial nitric oxide (NO) generation in sustaining a tonic systemic vasodilatation is well established. Inhibiting NO production produces hypertension in animals and in humans and not surprisingly there has been considerable interest in establishing whether deficiencies of endothelial NO pathway activity are implicated in the aetiology of essential hypertension. The results of these investigations have been inconsistent with some suggestion that observed deficiencies of both basal and stimulated endothelial NO generation in hypertensive subjects may be an effect rather than the cause of raised arterial pressure. It is increasingly recognised that neuronal production of NO also influences cardiovascular homeostasis through its action as a neuromodulator within the autonomic nervous system. Overall NO has been shown to have sym-

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Defective l -Arginine–Nitric Oxide Pathway in Offspring of Essential Hypertensive Patients

Abstract: Offspring of essential hypertensive patients are characterized by a reduced response to acetylcholine linked to a defect in the nitric oxide pathway, suggesting that an impairment in nitric oxide production precedes the onset of essential hypertension.

Cited by 281 publications

References 36 publications

Assessment of Endothelial Dysfunction in Health and Disease; Using Various Parameters

Assessment of Endothelial Dysfunction in Health and Disease; Using Various Parameters

Endothelial dysfunction and hypertension in aging

Nitric oxide and hypertension: not just an endothelium derived relaxing factor!

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