Assessment of Endothelial Dysfunction in Health and Disease; Using Various Parameters

Jalali, Maryam; Phadke, Madhavi S.

doi:10.1007/s12291-011-0140-4

Cited by 8 publications

(6 citation statements)

References 36 publications

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“…11 In the current study there was a significant correlation between CCAIMT and TC, TG, LDL, VLDL (p< 0.001 for all). It was also seen that CCAIMT increased with increase in the TC, TG, LDL, VLDL levels 12 The current study also observed a significant negative correlation between CCAIMT and HDL levels (p <0.001). It was also observed that CCAIMT was inversely proportional to HDL levels with correlation coefficient r= -0.730.…”

Section: Resultssupporting

confidence: 80%

Common Carotid Artery Intima-Media Thickness Reflects the Cumulative Burden of Atherosclerosis and Predicted Well by Total-C/HDL-C Ratio in Type-II Diabetic Patients- A Case Control Study Based from Kolkata, India

Dey

Kumar

et al. 2013

Asian J Med Sci

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Background: Diabetes Mellitus (DM) is frequently associated with the development of premature atherosclerotic vascular disease and is the major cause of morbidity and mortality. Approximately 80% of all deaths and more than 75% of all hospitalizations are due to CAD. Individuals with DM are usually associated with accelerated atherosclerosis. Common Carotid artery intima-media thickness (CCAIMT) is now also considered as a surrogate marker of atherosclerosis. Materials and Methods: This case-control study was conducted from Jan, 2011 to June, 2012 among Type-II diabetes, aged between 30-80yrs. Patients with Type-I diabetes, aged <30yrs or >80yrs and other secondary causes of diabetes, hypertensive, smokers and patients under therapy with lipid lowering drugs were excluded from this study. The biochemical tests were done in the department of Biochemistry, Nilratan Sarkar Medical College and Hospital, using standardized reagent kits. CCAIMT was measured by high resolution imaging using 10MHz transducer in the department of Radiodiagnosis, Nilratan Sarkar Medical College and Hospital. Results: The results of our study indicate that dyslipidemic diabetic patients had significantly higher blood glucose at any phase along with glycated haemoglobin compared to controls. The lipid variables were also significantly higher in the diabetes patients with dyslipidemia compared to controls except HDL levels were significantly higher in control. CCAIMT was higher in the dyslipidemic group (1.71 ± 0.57mm) compared to the non-dyslipidemic group (0.77 ± 0.10) which was statistically significant (p value <0.001). Conclusion: CCAIMT reflects the cumulative burden of atherosclerosis and is highly correlated and predicted well by Total-C/HDL-C ratio in Type-II diabetic patients. So it is advised that a direct examination of the vessel wall is extremely essential for early detection of the affected individuals so that the cost burden in Intensive coronary care unit can be minimized and also the individual can be advised to control the extensive dyslipidemia through dietary restrictions and exercise. DOI: http://dx.doi.org/10.3126/ajms.v5i1.8450 Asian Journal of Medical Science Vol.5(1) 2014 pp.9-14

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Section: Resultssupporting

confidence: 80%

Common Carotid Artery Intima-Media Thickness Reflects the Cumulative Burden of Atherosclerosis and Predicted Well by Total-C/HDL-C Ratio in Type-II Diabetic Patients- A Case Control Study Based from Kolkata, India

Dey

Kumar

et al. 2013

Asian J Med Sci

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“…Also, while uric acid levels in serum were not affected by the high fructose intake the high glucose diet led to a significant decrease. However, while systolic and diastolic blood pressure also remained unaffected by the different diets (Table 4), plasma NOx levels shown to be indicative of vascular endothelial dysfunction [15] were significantly lower after subjects had consumed the fructose-enriched diet for 3 days (-47%). A similar drop in NOx levels was not found after subjects had eaten the glucose-enriched diet (see Figure 2).…”

Section: Effect Of a Fructose-and Glucose-enriched Diet Respectivelymentioning

confidence: 99%

Short‐Term Isocaloric Intake of a Fructose‐ but not Glucose‐Rich Diet Affects Bacterial Endotoxin Concentrations and Markers of Metabolic Health in Normal Weight Healthy Subjects

Nier

Brandt

Rajcic

et al. 2019

Molecular Nutrition Food Res

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Scope Dietary pattern and impairments of intestinal barrier function are discussed to be critical in the development of metabolic impairments. Here, it is determined if an isocaloric exchange of complex carbohydrates with monosaccharides affects markers of intestinal permeability and metabolic health in healthy subjects. Methods and Results After a dietary standardization for 4 days, all 12 subjects aged 21–33 years receive an isocaloric fructose‐ and glucose‐enriched diet for 3 days separated by a wash‐out phase. Anthropometry, blood pressure, markers of intestinal permeability and metabolic as well as inflammatory parameters are determined in blood samples or isolated peripheral blood mononuclear cells collected at baseline, after standardizations and the monosaccharide interventions, respectively. While anthropometric and inflammatory parameters are not changed, the intake of an isocaloric fructose‐ but not glucose‐enriched diet is associated with a significant increase of bacterial endotoxin plasma levels and alanine aminotransferase activity in serum, while total plasma nitrate/nitrite concentrations are significantly decreased. In peripheral blood mononuclear cells, Toll like receptors 4, 2 , and MYD88 mRNA expressions are significantly induced after the fructose‐rich but not the glucose‐rich diet. Conclusion In metabolically healthy subjects, even a short‐term intake of a fructose‐rich diet can elevate bacterial endotoxin levels and change markers of liver health and vascular endothelial function.

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“…Forty patients were included in this study. The median hs-CRP, NO, and systolic BP (SBP) of the patients were 6.55 mg/dL (0.50-43.5), 27.77 mg/dL (20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30), respectively. The correlation analysis showed that there was a strong significant negative correlation between hs-CRP levels and NO (r = −0.680, p = 0.000).…”

Section: Resultsmentioning

confidence: 99%

“…Similarly, Jalali et al reported in a study of 179 patients with stage 5 ESRD on HD, it was found that an increase in hs-CRP was associated with endothelial dysfunction. hs-CRP levels also increase with age and worsening of the disease, which can lead to an increase in BP (p < 0.001) [23]. Some acute phase reactants such as CRP and ferritin are markers of inflammatory reactions caused by the stimulation of proinflammatory cytokines.…”

Section: Discussionmentioning

confidence: 99%

The Association of High Sensitivity C-reactive protein and Nitric Oxide with Elevated Blood Pressure during Dialysis in Intradialytic Hypertension

Palar,

Sugeng,

Umboh

et al. 2023

Open Access Maced J Med Sci

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BACKGROUND: Hemodialysis (HD) is a procedure to replace part of kidney function in patients with end-stage kidney disease. Hemodynamic disturbances during HD may include elevated blood pressure (BP). It is reported that about 5–15% of patients undergoing regular HD have increased BP during HD. This condition is called intradialytic hypertension (IDH). Increased high sensitivity C-reactive protein (hs-CRP) levels are associated with decreased endothelial dilatation response of blood vessels. Nitric Oxide (NO) is one of the mediators that act as a vasodilator to regulate vascular pressure. Endothelial dysfunction is one of the factors thought to contribute to the incidence of IDH. AIM: This study aimed to determine the association of hs-CRP and NO with elevated BP in IDH. METHODS: This observational cross-sectional study was conducted at Prof. Dr. R.D. Kandou General Hospital, Manado, from November 2021 to April 2022. Participants were selected through consecutive sampling methods. The levels of hs-CRP and NO were examined in all patients. The correlation between hs-CRP and NO was performed using the Spearman test, while the association of hs-CRP and NO with elevated BP was performed using the Fisher- exact test or Chi-square test. RESULTS: Forty patients were included in this study. The median hs-CRP, NO, and systolic BP (SBP) of the patients were 6.55 mg/dL (0.50–43.5), 27.77 mg/dL (3.65–72.19), and 20 mmHg (10–30), respectively. The correlation analysis showed that there was a strong significant negative correlation between hs-CRP levels and NO (r = −0.680, p = 0.000). Based on the Chi-Square or Fisher Exact test, there was a significant association between hs-CRP levels and elevated SBP (OR = 5.06; 95% CI = 1.095–23.44; p = 0.040), as well as between NO levels and elevated SBP (OR = 17.14; 95% CI = 3.063–95.938; p = 0.000). CONCLUSION: There was a significant association between hs-CRP and NO levels with elevated SBP in end-stage renal disease (ESRD) patients with IDH. ESRD on hemodialysis (ESRD on R-HD) patients with hs-CRP ≤3 mg/dL or NO levels <25 mg/dL tends to have increased SBP ≥20 mmHg after HD compared to ESRD patients with low hs-CRP or high NO levels.

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Assessment of Endothelial Dysfunction in Health and Disease; Using Various Parameters

Cited by 8 publications

References 36 publications

Common Carotid Artery Intima-Media Thickness Reflects the Cumulative Burden of Atherosclerosis and Predicted Well by Total-C/HDL-C Ratio in Type-II Diabetic Patients- A Case Control Study Based from Kolkata, India

Common Carotid Artery Intima-Media Thickness Reflects the Cumulative Burden of Atherosclerosis and Predicted Well by Total-C/HDL-C Ratio in Type-II Diabetic Patients- A Case Control Study Based from Kolkata, India

Short‐Term Isocaloric Intake of a Fructose‐ but not Glucose‐Rich Diet Affects Bacterial Endotoxin Concentrations and Markers of Metabolic Health in Normal Weight Healthy Subjects

The Association of High Sensitivity C-reactive protein and Nitric Oxide with Elevated Blood Pressure during Dialysis in Intradialytic Hypertension

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