Defective Regulation of the Protective IgE Response against Intestinal Helminth Ascaris lumbricoides in Malnourished Children

Hagel, Isabel; Nr, Lynch; Puccio, Franca; Rodríguez, Óscar; Luzondo, R.; Rodríguez, Patricia; Sánchez, Pedro; Cabrera, Maira; Prisco, María Cristina Di

doi:10.1093/tropej/49.3.136

Cited by 30 publications

(31 citation statements)

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“…Em resumo, há evidências razoáveis de que helmintos e outros agentes infecciosos podem induzir à proliferação inespecífica de células B ativadas, resultando em nível bastante elevado de IgE total, fato que deve ser freqüente em países pobres e em populações que não são adequadamente nutridas 32 . A resposta imunológica à infestação por parasitas intestinais envolve um passo inicial que é caracterizado por produção de IgE específica seguida por uma fase em que há uma síntese aumentada de IgE policlonal.…”

Section: Discussionunclassified

Total IgE level in respiratory allergy: study of patients at high risk for helminthic infection

Medeiros¹,

Silva²,

Rizzo³

et al. 2006

J Pediatr (Rio J)

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Objective: Eosinophilia and increased serum IgE levels are indicators of atopy; however, other factors can also play a key role, such as intestinal parasitic infections. This study assesses the relationship between total serum IgE, eosinophil count, and anti-Ascaris IgE in individuals with asthma and/or allergic rhinitis. Methods:A cross-sectional study was carried out in adolescents with asthma and/or allergic rhinitis. The patients had their total serum IgE, anti-Ascaris IgE and eosinophil count measured.Results: A total of 101 patients aged 12 to 21 years were assessed. Median IgE level was 660 IU/mL (P 25-75 243.5-1500), and the eosinophil count corresponded to 510 cells/mm 3 (P 25-75 284-811). Anti-Ascaris IgE was positive in 73% (74/101) of the individuals, but parasitological stool examination yielded positive results in only 33.7% (34/101). The correlation coefficients were the following: 0.34 (p = 0.001) between total IgE level and eosinophil count, 0.52 (p < 0.001) between total IgE level and anti-Ascaris IgE, and 0.26 (p = 0.01) between eosinophil count and anti-Ascaris IgE. The final multiple linear regression model pointed out that anti-Ascaris IgE contributed to a total serum IgE level with a coefficient of determination (adjusted R 2 ) of 0.25 (F = 12.35; p < 0.001). This effect occurred regardless of eosinophil count and of the presence of intestinal helminthic infection. Conclusion:In patients with respiratory allergy and increased total serum IgE levels living in areas where there is a high risk for helminthic infections, the quantification of anti-Ascaris IgE can be more useful and more insightful than the parasitological stool examination.J Pediatr (Rio J). 2006;82(4):255-9: IgE, eosinophils, allergy, helminthic infection, ascariasis. ResumoObjetivo: Eosinofilia e elevação de IgE sérica são expressões de atopia, contudo há fatores intervenientes como, por exemplo, as parasitoses intestinais. Esta pesquisa verifica a relação entre IgE sérica total, eosinófilos e IgE específica anti-áscaris em indivíduos portadores de asma e/ou rinite alérgica.Métodos: Estudo do tipo transversal em adolescentes portadores de asma e/ou rinite alérgica que foram examinados quanto ao nível sérico de IgE total, de IgE anti-áscaris e de contagem dos eosinófilos sangüíneos.Resultados: Foram analisados 101 pacientes com idade entre 12 e 21 anos. A mediana da IgE foi 660 UI/mL (P 25-75 243,5-1500), e a dos eosinófilos foi 510 células/mm 3 (P 25-75 284-811). A IgE anti-áscaris foi positiva em 73% (74/101) da amostra, mas houve apenas 33,7% (34/ 101) de positividade ao parasitológico de fezes. Os coeficientes de correlação encontrados foram: 0,34 (p = 0,001) entre IgE total e eosinófilos, 0,52 (p < 0,001) entre IgE total e IgE anti-áscaris e 0,26 (p = 0,01) entre eosinófilos e IgE anti-áscaris. O modelo de regressão linear múltipla final encontrou que IgE anti-áscaris foi fator contribuinte para IgE sérica total com coeficiente de determinação (r 2 ajustado) de 0,25 (F = 12,35; p < 0,001), e esse efeito foi indep...

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Section: Discussionunclassified

Total IgE level in respiratory allergy: study of patients at high risk for helminthic infection

Medeiros¹,

Silva²,

Rizzo³

et al. 2006

J Pediatr (Rio J)

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“…42 However, malnourished children with parasitic infections do show increased total IgE levels, but specific memory helper T-cell and specific IgE responses are reduced. 43 Activation of the hypothalamic-pituitary-adrenal (HPA) axis is critically involved in the cause of the immunodeficiency of malnutrition. Leptin levels normally increase acutely during infection and inflammation.…”

Section: Primary Malnutritionmentioning

confidence: 99%

Mechanisms of nutrient modulation of the immune response

Cunningham‐Rundles

McNeeley

Moon

2005

Journal of Allergy and Clinical Immunology

428

330

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“…In malnourished children with parasitic infections, specific IgE response is reduced (Hagel et al 2003). According to El Ridi et al (2001), published data taken together indicate that IgE is neither essential nor detrimental to protection against S. mansoni in the primary infection.…”

Section: Immune Response In Undernourished Mice Infected With S Mansonimentioning

confidence: 99%

Manson's schistosomiasis in the undernourished mouse: some recent findings

Coutinho

Oliveira

Barros

et al. 2010

Mem. Inst. Oswaldo Cruz

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This paper deals with current knowledge of the interrelationships between Schistosoma infection and malnutrition. It emphasizes the relevance of these investigations in the face of dynamic and evolving changes occurring in population diets and changes in the epidemiological patterns of schistosomiasis in endemic countries. The paper further discusses the basis for continuing the studies on this subject and the reasons why it represents a misunderstood association. This review also focuses on the cellular and humoral immune responses in the undernourished mouse model infected with Schistosoma mansoni, with updated information on the immune response in wild-type and iNOS knockout mice concerning soluble egg antigen specific antibodies and kinetics of IFN-γ, IL-4, IL-10 and IL-13 cytokines, in the chronic phase of Manson's schistosomiasis. There is indication that schistosome-infected undernourished mice are able to develop a humoral immune response, but antibody titres are much lower than in the control animals. Cytokine production (IFN-γ, IL-4, IL-10) is lower in the undernourished mice, but as infection progresses to the chronic phase its kinetics run an antagonistic course when compared to that of well-nourished animals. Marked variation in the secretion of IL-13 (a fibrogenic cytokine) could explain why undernourished mice do not develop liver "pipe-stem" fibrosis described in previous papers on well-nourished animals

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Defective Regulation of the Protective IgE Response against Intestinal Helminth Ascaris lumbricoides in Malnourished Children

Cited by 30 publications

References 0 publications

Total IgE level in respiratory allergy: study of patients at high risk for helminthic infection

Total IgE level in respiratory allergy: study of patients at high risk for helminthic infection

Mechanisms of nutrient modulation of the immune response

Manson's schistosomiasis in the undernourished mouse: some recent findings

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