Deep‐seated rectal/anal basaloid carcinoma: useful immunocytochemistry in rare squamous cell carcinoma variants

Ghigna, Maria Rosa; Alsibai, Kinan Drak; Porras, J.; Palazzo, Laurent; Godchaux, J. M.; Fabrè, Monique

doi:10.1111/j.1365-2303.2008.00560.x

Cited by 6 publications

(9 citation statements)

References 24 publications

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“…In addition, the remaining LBC materials left over from cytologic analysis can be used for immunocytochemistry; one of the most important advantages of using LBC is the ability to perform immunocytochemistry, which has been used on cervical LBC for biomarkers such as P16. Today, LBC with immunocytochemistry is extensively used for non-gynecological specimens to improve the diagnostic accuracy or to know the expressions of the hormone receptors [20,21,22,23]. For most types of cancer, a biopsy is the only way to make a diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Vaginal Stump Metastasis from Sigmoid Colon Cancer

Tanaka¹,

Kanda²,

Sakaguchi³

et al. 2012

Acta Cytologica

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Background: Vaginal metastasis from organs other than the uterus is rare. Generally, patients with vaginal metastasis from colorectal cancer have a dismal prognosis. Although biopsy is the best method to make the diagnosis, massive bleeding may occur. On the other hand, liquid-based cytology (LBC) has the utility to perform immunocytochemistry on additional unstained slides: we can make a diagnosis with several immunocytochemical findings. Case: A 67-year-old postmenopausal female presented to our hospital with vaginal bleeding. The patient had undergone colectomy because of her stage III sigmoid colon cancer 3 years earlier. The patient had also undergone hysterectomy for cervical cancer 30 years earlier. LBC from the vaginal stump revealed adenocarcinoma. Immunocytochemically, cancer cells were negative for cytokeratin 7 and positive for cytokeratin 20, which suggested metastasis from the sigmoid colon cancer; the diagnosis was made without a biopsy. Conclusion: When the patient has a metastatic lesion from colon adenocarcinoma, LBC with immunocytochemistry is useful in making a diagnosis.

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Section: Discussionmentioning

confidence: 99%

Vaginal Stump Metastasis from Sigmoid Colon Cancer

Tanaka¹,

Kanda²,

Sakaguchi³

et al. 2012

Acta Cytologica

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“…Immunohistochemistry may be useful for confirming the tissue origin of the tumor, which expresses CK20, CK7, CK34BE12 and p63. 10,11 The patient in question had the basaloid type, for which chemotherapy was contraindicated because of leukopenia, with lung metastases. She was being followed up in the palliative care outpatient department.…”

Section: Discussionmentioning

confidence: 99%

Metástase cutânea rara de provável carcinoma basaloide de cólon simulando granuloma piogênico

Verardino

Silva

Obadia

et al. 2011

An. Bras. Dermatol.

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Acrometastasis is a rare occurrence, especially when affecting the hands. It represents around 0.007-0.2% of all metastatic lesions. The most common site of origin is the lung, accounting for 40-50% of all cases reported in the literature. Kidneys and breasts are other sites also associated with neoplastic lesions that disseminate to the hands. More rarely, the site of origin may be the gastrointestinal tract or other systemic tumors or sarcomas. Early diagnosis is difficult, since the condition may be asymptomatic or may mimic tenosynovitis, arthritis, paronychia, pyogenic granuloma or a local infection. In the present paper, the authors report on a patient with the diagnosis of acrometastasis on both hands originating from a basaloid carcinoma of the anal canal. Response to radiotherapy was poor. Keywords: Colonic neoplasms; Granuloma, pyogenic; Neoplasm metastasisResumo: As acrometástases, principalmente para as mãos, são incomuns e representam cerca de 0,007-0,2% de todas as lesões metastáticas. O pulmão é o sítio de origem mais comum, colaborando com 40-50% dos casos relatados na literatura. Os rins e mamas são outras localizações também relacionadas a neoplasias que metastatizam para as mãos, além de, mais raramente, trato gastrointestinal, outros tumores sistêmicos e sarcomas. Seu diagnóstico precoce é difícil, pois pode ser assintomático, se assemelhar a tenossinovite, artrite, paroníquia, granuloma piogênico ou infecção local. No presente relato, os autores apresentam paciente com diagnóstico de acrometástase, em ambos os quartos quirodáctilos, oriunda de carcinoma basaloide de canal anal, com pobre resposta à radioterapia.

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“…Because of its rarity, particularly in the posttransplantation setting, the optimal treatment strategy has not been established. [1][2][3][4][5] Options include an immunologic approach to maximize potential graft-versus-tumor effect through withdrawal of immunosuppression and/or donor leukocyte infusion, radiation therapy, chemotherapy, and total body electron therapy.…”

Section: Isolated Cutaneous Extramedullary Relapse Of Leukemia Confirmentioning

confidence: 99%

“…CK7 was focally positive in one case and negative in the second case. 5 To our knowledge, no cases of cutaneous metastases from rectal SCC have been reported. Several cases in the literature describe metastasis to the liver and lungs via the portal circulation.…”

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confidence: 90%

“…Several cases in the literature describe metastasis to the liver and lungs via the portal circulation. 2,3,5 In addition to lung metastasis, our patient had documented brain, spine, and skin metastases with spread likely via Batson's plexus, a network of veins that connects the rectal circulation to the vertebral and systemic circulation. Surgical resection is the treatment of choice for rectal SCC.…”

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confidence: 91%

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