Dedicated 3D photoacoustic breast imaging

Kruger, Robert A.; Kuzmiak, Cherie M.; Lam, Richard B.; Reinecke, Daniel R.; Rio, Stephen P. Del; Steed, Doreen

doi:10.1118/1.4824317

Cited by 205 publications

(202 citation statements)

References 22 publications

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“…(Fig 4). Photoacoustic CT was performed in four healthy patients and demonstrated the feasibility of clinical breast imaging with submillimeter resolution (64). The scanning time was reported to be between 12 seconds and 3.2 minutes for circular beam, 10 Hz, 10 mJ/cm 2 ) and custom data acquisition system (Fig 4).…”

Section: Clinical Applications Of Photoacoustic Imagingmentioning

confidence: 99%

“…C, Photoacoustic tomography system (Optosonics) consists of a patient bed with an aperture. Laser is delivered from beneath the breast, and a rotating hemispherical array of US transducers acquires photoacoustic images (64). D, Laser optoacoustic imaging system (LOIS-64) developed by Ermilov et al consists of a setup similar to the Optosonics system, with a hemispherical array of annular US detectors (60).…”

Section: Clinical Applications Of Photoacoustic Imagingmentioning

confidence: 99%

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Photoacoustic Imaging in Oncology: Translational Preclinical and Early Clinical Experience

Valluru¹,

Wilson²,

Willmann³

2016

Radiology

159

107

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Section: Clinical Applications Of Photoacoustic Imagingmentioning

confidence: 99%

Section: Clinical Applications Of Photoacoustic Imagingmentioning

confidence: 99%

Photoacoustic Imaging in Oncology: Translational Preclinical and Early Clinical Experience

Valluru¹,

Wilson²,

Willmann³

2016

Radiology

159

107

View full text Add to dashboard Cite

“…Over the last decade, it has been extensively used to study genetics, vasculature, brain disorders, arthritis, cancers, and nanomaterials [19,[23][24][25]. Several groups have employed different PAI systems to study zebrafish.…”

Section: Introductionmentioning

confidence: 99%

Label-free photoacoustic imaging of the cardio-cerebrovascular development in the embryonic zebrafish

Chen¹,

Jin²,

Qi³

et al. 2017

Biomed. Opt. Express

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Abstract:Zebrafish play an important role in biology, pharmacology, toxicology, and medicine. The cardio-cerebrovascular development of zebrafish is particularly critical to understand both brain disorders and cardiovascular diseases in human. In this paper, we applied optical resolution photoacoustic microscopy (ORPAM) to image the whole-body vasculature of the embryonic zebrafish with a special focus on the development of the cardiocerebrovascular system. Using the intrinsic optical absorption contrast of the embryo, we successfully visualized the formation of the cardio-cerebrovascular network in highresolution using a 10 × objective, and monitored the whole-body vascular development using a 4 × objective. In addition, we evaluated the impact of the eggshell and pigment inhibitor on the image quality. Our results suggest that ORPAM is capable of studying the cardiocerebrovascular development of zebrafish in the embryonic stage, and thus has the potential to investigate the cardiovascular and cerebrovascular diseases of human in the future.

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“…28), and progress with fast tuning light sources (24) has led to breakthrough MSOT implementations that are capable of high-quality real-time imaging. Systems using multi-element ultrasound detector arrays have demonstrated not only 2D real-time imaging (29,30), but also 3D real-time imaging of tissue volumes (28,31), as also shown in Fig. 6A-E. Real-time handheld MSOT operation in a form similar to diagnostic ultrasound imaging can be considered a crucial step toward clinical applications (32-37), particularly when combined with fast wavelength tuning (24).…”

Section: Advances In Real-time 2d and 3d Handheld Operationmentioning

confidence: 99%

Mesoscopic and Macroscopic Optoacoustic Imaging of Cancer

2015

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Optoacoustic imaging combines the rich contrast of optical methods with the resolution of ultrasound imaging. It can therefore deliver optical visualization of cancer far deeper in tissue than optical microscopy and other conventional optical imaging methods. Technological progress and novel contrast media have resulted in optoacoustic imaging being propagated to basic cancer research and in clinical translation projects. We briefly review recent technological advances, showcase the ability to resolve unique cancer biomarkers based on spectral features at different imaging scales, and highlight the imaging performance achieved in preclinical and clinical imaging applications.

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Dedicated 3D photoacoustic breast imaging

Abstract: CNR, lateral field-of-view and penetration depth of our dedicated PAM scanning system is sufficient to image breasts as large as 1335 mL, which should accommodate up to 90% of the women in the United States.

Cited by 205 publications

References 22 publications

Photoacoustic Imaging in Oncology: Translational Preclinical and Early Clinical Experience

Photoacoustic Imaging in Oncology: Translational Preclinical and Early Clinical Experience

Label-free photoacoustic imaging of the cardio-cerebrovascular development in the embryonic zebrafish

Mesoscopic and Macroscopic Optoacoustic Imaging of Cancer

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