Photoacoustic Imaging in Oncology: Translational Preclinical and Early Clinical Experience

Valluru, K.; Wilson, Katheryne E.; Willmann, Jürgen K.

doi:10.1148/radiol.16151414

Cited by 159 publications

(109 citation statements)

References 123 publications

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“…97 For a discussion of the clinical status and potential of each of these imaging modalities, we point the reader towards several recent papers that provide an excellent summary of the benefits and limitations of each of these imaging modalities in the clinical setting. [98][99][100][101]…”

Section: Image-guidance and Assessment Of Ptt Using Gold Nanoparticlesmentioning

confidence: 99%

Gold nanoparticle‐mediated photothermal therapy: applications and opportunities for multimodal cancer treatment

Riley

Day

2017

WIREs Nanomed Nanobiotechnol

598

454

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Photothermal therapy (PTT), in which nanoparticles embedded within tumors generate heat in response to exogenously applied laser light, has been well documented as an independent strategy for highly selective cancer treatment. Gold-based nanoparticles are the main mediators of PTT because they offer: (1) biocompatibility, (2) small diameters that enable tumor penetration upon systemic delivery, (3) simple gold-thiol bioconjugation chemistry for the attachment of desired molecules, (4) efficient light-to-heat conversion, and (5) the ability to be tuned to absorb near-infrared light, which penetrates tissue more deeply than other wavelengths of light. In addition to acting as a standalone therapy, gold nanoparticle-mediated PTT has recently been evaluated in combination with other therapies, such as chemotherapy, gene regulation, and immunotherapy, for enhanced anti-tumor effects. When delivered independently, the therapeutic success of molecular agents is hindered by premature degradation, insufficient tumor delivery, and off-target toxicity. PTT can overcome these limitations by enhancing tumor- or cell-specific delivery of these agents or by sensitizing cancer cells to these additional therapies. All together, these benefits can enhance the therapeutic success of both PTT and the secondary treatment while lowering the required doses of the individual agents, leading to fewer off-target effects. Given the benefits of combining gold nanoparticle-mediated PTT with other treatment strategies, many exciting opportunities for multimodal cancer treatment are emerging that will ultimately lead to improved patient outcomes.

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Section: Image-guidance and Assessment Of Ptt Using Gold Nanoparticlesmentioning

confidence: 99%

Gold nanoparticle‐mediated photothermal therapy: applications and opportunities for multimodal cancer treatment

Riley

Day

2017

WIREs Nanomed Nanobiotechnol

598

454

View full text Add to dashboard Cite

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“…PA imaging is an emerging hybrid imaging modality providing both optical absorptive contrast and acoustic imaging depth, and it also supports versatile imaging scales by microscopic (5 µm of spatial resolution for up to 2 mm-depth) and tomographic imaging configurations (~800 µm of spatial resolution for up to 7-cm depth). [31][32][33] Also, recently, several PA neuroimaging researchers have proposed to quantify membrane potential variations using a genetically-encoded calcium indicator or non-radiative voltage sensor. 34,35 We have also shown the concept of novel functional PA imaging of membrane potential variation in vivo using the same cyanine VSD used in this study.…”

Section: Discussionmentioning

confidence: 99%

Real-time, functional intra-operative localization of rat cavernous nerve network using near-infrared cyanine voltage-sensitive dye imaging

Kang

Karakus³

et al. 2019

Preprint

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AbstractDespite current progress achieved in the surgical technique of radical prostatectomy, post-operative complications such as erectile dysfunction and urinary incontinence persist at high incidence rates. In this paper, we present a methodology for functional intra-operative localization of the cavernous nerve (CN) network for nerve-sparing radical prostatectomy using near-infrared cyanine voltage-sensitive dye (VSD) imaging, which visualizes membrane potential variations in the CN and its branches (CNB) in real time. As a proof-of-concept experiment, we demonstrate a functioning complex nerve network in response to electrical stimulation of the CN, which was clearly differentiated from surrounding tissues in an in vivo rat prostate model. Stimulation of an erection was confirmed by correlative intracavernosal pressure (ICP) monitoring. Within 10 minutes, we performed trans-fascial staining of the CN by direct VSD administration. Our findings suggest the applicability of VSD imaging for real-time, functional imaging guidance during nerve-sparing radical prostatectomy.

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“…However, this is not the fundamental issue of photoacoustic. Through the utilization of multispectral strategy and acoustic Doppler effect, it is feasible to estimate the concentrations of oxygen-and dioxygen-hemoglobin, oxygen saturation and blood flow, making the assessment more accurate [24,25]. Secondly, the imaging depth is still limited by both the transparency of tissue and excitation wavelength.…”

Section: Discussionmentioning

confidence: 99%

Assessing hemorrhagic shock: Feasibility of using an ultracompact photoacoustic microscope

Chen

Guo

et al. 2018

Journal of Biophotonics

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Hemorrhagic shock, as an important clinical issue, is regarding as a critical disease with a high mortality rate. Unfortunately, existing clinical technologies are inaccessible to assess the hemorrhagic shock via hemodynamics in microcirculation. Here, we propose an ultracompact photoacoustic microscope to assess hemorrhagic shock using a rat model and demonstrate its clinical feasibility by visualizing buccal microcirculation of healthy volunteers. Both functional and morphological features of the microvascular network including concentration of total hemoglobin (CHbT), number of blood vessels (VN), small vascular density (SVD) and vascular diameter (VD) were derived to assess the microvascular hemodynamics of different organs. Animal studies show the feasibility of the proposed tool to assess and stage the hemorrhagic shock via microcirculation. in vivo oral imaging of healthy volunteers indicates the translational possibility of this technique for clinical evaluation of hemorrhagic shock.

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Photoacoustic Imaging in Oncology: Translational Preclinical and Early Clinical Experience

Cited by 159 publications

References 123 publications

Gold nanoparticle‐mediated photothermal therapy: applications and opportunities for multimodal cancer treatment

Gold nanoparticle‐mediated photothermal therapy: applications and opportunities for multimodal cancer treatment

Real-time, functional intra-operative localization of rat cavernous nerve network using near-infrared cyanine voltage-sensitive dye imaging

Assessing hemorrhagic shock: Feasibility of using an ultracompact photoacoustic microscope

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