Mesoscopic and Macroscopic Optoacoustic Imaging of Cancer

Taruttis, Adrian; Dam, Gooitzen M. van; Ntziachristos, Vasilis

doi:10.1158/0008-5472.can-14-2522

Cited by 98 publications

(84 citation statements)

References 92 publications

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“…When the pulse laser irradiation (thermoacoustic imaging, especially with the pulse of radio frequency laser irradiation) in biological tissue, tissue optical absorption domain will produce ultrasonic signal; we call this by ultrasonic signal as the excitation light produced by PA signal. [6][7][8][9][10][11][12] The PA signal generated by the biological tissue carries the information of optical absorption characteristics of the tissue, and the optical absorption distribution image can be reconstructed by detecting the PA signal.…”

Section: Introductionmentioning

confidence: 99%

Photoacoustic molecular imaging with functional nanoparticles

Qin

2017

J. Innov. Opt. Health Sci.

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Photoacoustic imaging (PAI) breaks through the optical di®usion limit by making use of the PA e®ect. By converting incident photons into ultrasonic waves, PAI combines high contrast of optical imaging and high spatial resolution in depth tissue of ultrasound imaging in a single imaging modality. This imaging modality has now shown potential for molecular imaging, which enables visualization of biological processes with systemically introduced functional nanoparticles. In the current review, the potentials of di®erent optical nanoprobes as PAI contrast agents were elucidated and discussed.

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Section: Introductionmentioning

confidence: 99%

Photoacoustic molecular imaging with functional nanoparticles

Qin

2017

J. Innov. Opt. Health Sci.

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“…To overcome these limitations a variety of molecular imaging techniques have been developed to investigate in vivo events, making use of such modalities as optical, MRI, PET, SPECT, and ultrasound. 20,22–27 Each of these modalities has unique advantages and disadvantages regarding sensitivity, spatial/temporal resolution, and the type of radiation or lack thereof. The in vivo detection limits of each modality can be augmented by using contrast agents and reporter probes and are used in applications such as cell tracking, reporting gene expression, and monitoring therapeutic paradigms.…”

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confidence: 99%

A Markedly Improved Synthetic Approach for the Preparation of Multifunctional Au-DNA Nanoparticle Conjugates Modified with Optical and MR Imaging Probes

et al. 2018

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We describe a new, and vastly superior approach for labeling spherical nucleic acid conjugates (SNAs) with diagnostic probes. SNAs have been shown to provide the unique ability to traverse the cell membrane and deliver surface conjugated DNA into cells while preserving the DNA from nuclease degradation. Our previous work on preparing diagnostically labeled SNAs was labor intensive, relatively low yielding, and costly. Here, we describe a straightforward and facile preparation for labeling SNAs with optical and MR imaging probes with significantly improved physical properties. The synthesis of Gd(III) labeled DNA Au nanoparticle conjugates is achieved by sequential conjugation of 3′-thiol-modified oligonucleotides and cofunctionalization of the particle surface with the subsequent addition of 1,2 diothiolate modified chelates of Gd(III) (abbreviated: DNA-GdIII@AuNP). This new generation of SNA conjugates has a 2-fold increase of DNA labeling and a 1.4-fold increase in Gd(III) loading compared to published constructs. Furthermore, the relaxivity (r1) is observed to increase 4.5-fold compared to the molecular dithiolane-Gd(III) complex, and 1.4-fold increase relative to previous particle constructs where the Gd(III) complexes were conjugated to the oligonucleotides rather than directly to the Au particle. Importantly, this simplified approach (2 steps) exploits the advantages of previous Gd(III) labeled SNA platforms; however, this new approach is scalable and eliminates modification of DNA for attaching the contrast agent, and the particles exhibit improved cell labeling.

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“…PAT has received great interests due to promising applications in disease diagnoses and life science researches34567. PAT detects optically induced ultrasound signals to form three-dimensional images8910.…”

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confidence: 99%

Fiber-Laser-Based Ultrasound Sensor for Photoacoustic Imaging

Liang

Jin

Wang

et al. 2017

Sci Rep

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Photoacoustic imaging, especially for intravascular and endoscopic applications, requires ultrasound probes with miniature size and high sensitivity. In this paper, we present a new photoacoustic sensor based on a small-sized fiber laser. Incident ultrasound waves exert pressures on the optical fiber laser and induce harmonic vibrations of the fiber, which is detected by the frequency shift of the beating signal between the two orthogonal polarization modes in the fiber laser. This ultrasound sensor presents a noise-equivalent pressure of 40 Pa over a 50-MHz bandwidth. We demonstrate this new ultrasound sensor on an optical-resolution photoacoustic microscope. The axial and lateral resolutions are 48 μm and 3.3 μm. The field of view is up to 1.57 mm2. The sensor exhibits strong resistance to environmental perturbations, such as temperature changes, due to common-mode cancellation between the two orthogonal modes. The present fiber laser ultrasound sensor offers a new tool for all-optical photoacoustic imaging.

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Mesoscopic and Macroscopic Optoacoustic Imaging of Cancer

Cited by 98 publications

References 92 publications

Photoacoustic molecular imaging with functional nanoparticles

Photoacoustic molecular imaging with functional nanoparticles

A Markedly Improved Synthetic Approach for the Preparation of Multifunctional Au-DNA Nanoparticle Conjugates Modified with Optical and MR Imaging Probes

Fiber-Laser-Based Ultrasound Sensor for Photoacoustic Imaging

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