Decreased Serum Prolidase Activity and Increased Oxidative Stress in Early Pregnancy Loss

Toy, Harun; Camuzcuoğlu, Hakan; Camuzcuoğlu, Aysun; Çelik, Hakim; Aksoy, Nurten

doi:10.1159/000262608

Cited by 27 publications

(20 citation statements)

References 58 publications

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“…Its levels were also shown to negatively correlate with increased OS, possibly accounting for the heightened placental vascular resistance and endothelial dysfunction secondary to decreased and dysregulated collagen turnover [156]. …”

Section: Pregnancy Complicationsmentioning

confidence: 99%

The effects of oxidative stress on female reproduction: a review

Agarwal

Aponte-Mellado

Premkumar

et al. 2012

Reprod Biol Endocrinol

1,389

1,188

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Oxidative stress (OS), a state characterized by an imbalance between pro-oxidant molecules including reactive oxygen and nitrogen species, and antioxidant defenses, has been identified to play a key role in the pathogenesis of subfertility in both males and females. The adverse effects of OS on sperm quality and functions have been well documented. In females, on the other hand, the impact of OS on oocytes and reproductive functions remains unclear. This imbalance between pro-oxidants and antioxidants can lead to a number of reproductive diseases such as endometriosis, polycystic ovary syndrome (PCOS), and unexplained infertility. Pregnancy complications such as spontaneous abortion, recurrent pregnancy loss, and preeclampsia, can also develop in response to OS. Studies have shown that extremes of body weight and lifestyle factors such as cigarette smoking, alcohol use, and recreational drug use can promote excess free radical production, which could affect fertility. Exposures to environmental pollutants are of increasing concern, as they too have been found to trigger oxidative states, possibly contributing to female infertility. This article will review the currently available literature on the roles of reactive species and OS in both normal and abnormal reproductive physiological processes. Antioxidant supplementation may be effective in controlling the production of ROS and continues to be explored as a potential strategy to overcome reproductive disorders associated with infertility. However, investigations conducted to date have been through animal or in vitro studies, which have produced largely conflicting results. The impact of OS on assisted reproductive techniques (ART) will be addressed, in addition to the possible benefits of antioxidant supplementation of ART culture media to increase the likelihood for ART success. Future randomized controlled clinical trials on humans are necessary to elucidate the precise mechanisms through which OS affects female reproductive abilities, and will facilitate further explorations of the possible benefits of antioxidants to treat infertility.

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Section: Pregnancy Complicationsmentioning

confidence: 99%

The effects of oxidative stress on female reproduction: a review

Agarwal

Aponte-Mellado

Premkumar

et al. 2012

Reprod Biol Endocrinol

1,389

1,188

View full text Add to dashboard Cite

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“…Prolidase activity is related to the pathogenesis of various diseases Savas et al 2010;Sezen et al 2010;Toy et al 2009aToy et al , 2010Vural et al 2010b;Yildiz et al 2008a). Since its property of representation of collagen turnover, prolidase is an important marker for tumour size and aggression of the fi broid growth (Wolanska et al 2001).…”

Section: Introductionmentioning

confidence: 99%

Oxidative stress and prolidase activity in women with uterine fibroids

Vural

Camuzcuoğlu

Toy

et al. 2011

Journal of Obstetrics and Gynaecology

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The aim of this study was to investigate oxidative stress markers and prolidase activity in serum and tissue samples of women with uterine fibroids, with further analysis on position and size. Lipid hydroperoxide, ceruloplasmin, catalase, arylesterase, free sulfhydryl group activity and prolidase activity levels were measured in fibroid tissue, myometrial tissue and serum of the same patients (n = 51), at the same time. Results show that ceruloplasmin, catalase, arylesterase, free sulfhydryl group and prolidase activities were higher in fibroid tissue than those in myometrial tissue (p = 0.003, 0.009, 0.004, 0.02, 0.008, respectively). Serum levels of catalase and prolidase were lower, and arylesterase and free sulfhydryl groups were higher in the fibroid group than those in the control group (p < 0.001 for all). Fibroid volume in submucosal subgroup of the fibroid group yield significant correlation with ceruloplasmin, catalase, arylesterase and prolidase activities (r = 0.84, p = 0.02; r = 0.93, p < 0.001; r = 0.63, p = 0.049 and r = 0.87, p = 0.01, respectively). Despite the lack of statistical significance, the highest levels of prolidase activity were found in fibroid samples, especially in submucosal ones. It is concluded that this study demonstrated increased antioxidative repair system in the fibroid tissue compared to the myometrium and serum of the same patients. Additionally, higher pathophysiological potential of the submucosal fibroids over intramural and subserosal fibroids were shown with the levels of oxidative stress markers and prolidase activity levels.

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“…However, on the basis of some of the past studies, a direct effect of vitamin E on the erythroid cells for induction of Hb appears plausible. For example, in mouse model, vitamin E Infertility duration (in years) 5.69±2.71 6 (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11) All the values quoted as the mean±SD and median (min-max). Unpaired t-test was used to compare the results between two groups.…”

Section: Discussionmentioning

confidence: 99%

“…[3][4][5][6] One study of 45 women that had experienced recurrent pregnancy loss found significantly decreased total antioxidant capacity (TAC) and increased total oxidative National Journal of Physiology, Pharmacy and Pharmacologystatus among these women compared to healthy pregnant controls. [7] α-tocopherol is the chemical name for the most active form of vitamin E. Vitamin E (α-tocopherol) is an exogenous, lipid soluble potent antioxidant molecule. [8] It is thought to be a direct free radical scavenger by activating the intracellular antioxidant enzymes and saving the cell membranes from lipid peroxidation.…”

Section: Introductionmentioning

confidence: 99%

Status of and #945;-tocopherol concentration and oxidative stress in infertile females of Vijayapur District, northern Karnataka

Jargar¹,

Dhundasi²,

Punekar³

2017

Natl J Physiol Pharm Pharmacol

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Background: Female fertility declined in Karnataka. Oxidative stress leads to anovulation, dysfunctional oocytes, fertilization failure, implantation failure, or miscarriage. Vitamin E (α-tocopherol) has the ability of fertilized egg to implant into uterine wall properly. Aims and Objective: The aims and objectives of the study were to establish the serum concentration of α-tocopherol and lipid peroxide (LPO) level in infertile females of northern Karnataka compared to age-matched control. Materials and Methods: Infertile females 20-35 years of age were selected prospectively, and age-matched fertile females were included in the study and divided into two groups: 45 normal fertile females (Group I) and equal number of infertile females (Group II). Body mass index (BMI), blood glucose level, and hemoglobin (Hb) levels were estimated with standard methods. α-tocopherol concentration was determined by non-antibody coated microplate method by using enzyme-linked immunosorbent assay reader. LPO level was assessed by malondialdehyde quantification using spectrophotometry. Results: Infertile females showed any statistical difference in BMI and random blood glucose, but Hb levels reduced significantly as compared to fertile females. The mean duration of infertility was 5.69 years. In infertile females, serum α-tocopherol was decreased significantly from 16.88 to 8.87 μg/L which is 45.78% and serum LPO level was increased from 1.25 to 2.13 μmol/L, which is 70.40% as compared to fertile females. Conclusion: Infertile females of northern Karnataka showed lower α-tocopherol levels and greater potential for oxidative stress as compared to fertile females. These findings demonstrate imbalance in ROS production and antioxidant.

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Decreased Serum Prolidase Activity and Increased Oxidative Stress in Early Pregnancy Loss

Cited by 27 publications

References 58 publications

The effects of oxidative stress on female reproduction: a review

The effects of oxidative stress on female reproduction: a review

Oxidative stress and prolidase activity in women with uterine fibroids

Status of and #945;-tocopherol concentration and oxidative stress in infertile females of Vijayapur District, northern Karnataka

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