Decreased retinal nerve fiber and choroidal thickness in chronic rhinosinusitis

Karakahya, Refika Hande; Korkmaz, Mukadder; Korkmaz, Hakan

doi:10.1007/s00405-020-06552-0

Cited by 2 publications

(3 citation statements)

References 29 publications

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“… 33 The resulting hypoxia may initiate retinal dilatation of the SCP to meet the ganglion cell layer’s metabolic demands. 34 This hypothesis is supported by the observation that total retinal blood flow as measured using laser Doppler velocimetry combined with vessel diameter measurement increases in early DM. 35 This results in the shunting of blood through the SCP rather than traversing the intermediate and deep capillary plexus, which was also demonstrated in diabetic rats.…”

Section: Discussionmentioning

confidence: 86%

“…The retinal oxygen metabolism is altered in DM and oxygen extraction was found to decrease with the worsening of DR severity 33. The resulting hypoxia may initiate retinal dilatation of the SCP to meet the ganglion cell layer’s metabolic demands 34. This hypothesis is supported by the observation that total retinal blood flow as measured using laser Doppler velocimetry combined with vessel diameter measurement increases in early DM 35.…”

Section: Discussionmentioning

confidence: 93%

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Ocular microvascular complications in diabetic retinopathy: insights from machine learning

Ahmed,

Shah,

Zhen

et al. 2024

BMJ Open Diab Res Care

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IntroductionDiabetic retinopathy (DR) is a leading cause of preventable blindness among working-age adults, primarily driven by ocular microvascular complications from chronic hyperglycemia. Comprehending the complex relationship between microvascular changes in the eye and disease progression poses challenges, traditional methods assuming linear or logistical relationships may not adequately capture the intricate interactions between these changes and disease advances. Hence, the aim of this study was to evaluate the microvascular involvement of diabetes mellitus (DM) and non-proliferative DR with the implementation of non-parametric machine learning methods.Research design and methodsWe conducted a retrospective cohort study that included optical coherence tomography angiography (OCTA) images collected from a healthy group (196 eyes), a DM no DR group (120 eyes), a mild DR group (71 eyes), and a moderate DR group (66 eyes). We implemented a non-parametric machine learning method for four classification tasks that used parameters extracted from the OCTA images as predictors: DM no DR versus healthy, mild DR versus DM no DR, moderate DR versus mild DR, and any DR versus no DR. SHapley Additive exPlanations values were used to determine the importance of these parameters in the classification.ResultsWe found large choriocapillaris flow deficits were the most important for healthy versus DM no DR, and became less important in eyes with mild or moderate DR. The superficial microvasculature was important for the healthy versus DM no DR and mild DR versus moderate DR tasks, but not for the DM no DR versus mild DR task—the stage when deep microvasculature plays an important role. Foveal avascular zone metric was in general less affected, but its involvement increased with worsening DR.ConclusionsThe findings from this study provide valuable insights into the microvascular involvement of DM and DR, facilitating the development of early detection methods and intervention strategies.

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Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 93%

Ocular microvascular complications in diabetic retinopathy: insights from machine learning

Ahmed,

Shah,

Zhen

et al. 2024

BMJ Open Diab Res Care

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“…It is known that even slight hypoxia changes the oxygen gradient between the choroidal capillaries and the outer retina, which in turn slows down the metabolic activity of the photoreceptors (Steinberg 1987;Yancey & Linsenmeier 1989;Lin et al 2012). In contrast, the ganglion cell layer seems to be more vulnerable in response to hypoxia, which may trigger an autoregulatory response particularly in the superior vascular layers (Ugurlu et al 2018;Karakahya et al 2021). However, further studies are needed to clarify this issue.…”

Section: Discussionmentioning

confidence: 99%

Effect of hyperoxia and hypoxia on retinal vascular parameters assessed with optical coherence tomography angiography

Hommer

Kallab

Sim

et al. 2021

Acta Ophthalmologica

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To investigate the response of the superficial and deep capillary plexuses to hyperoxia and hypoxia using optical coherence tomography angiography (OCT-A) and retinal vessel analyzer.Methods: Twenty-four healthy volunteers participated in this randomized, double-masked, crossover study. For each subject, two study days were scheduled: on one study day, hyperoxia was induced by breathing 100% oxygen whereas on the other study day, hypoxia was induced by breathing a mixture of 88% nitrogen and 12% oxygen. Perfusiondensity wascalculated in the superficial vascular plexus (SVP) and the deep capillary plexus (DCP), using OCT-A before (normal breathing) and during breathing of the gas mixtures. Retinal vessel calibres in major retinal vessels were measured using a dynamic vessel analyzer.Results: During 100% oxygen breathing, a significant decrease in DCP perfusion density from 41.7 AE 2.4 a.u to 35.6 AE 3.1 a.u. (p < 0.001) was observed, which was accompanied by a significant decrease in vessel diameters in majorretinal arteries and veins(p < 0.001 each). No significant change in perfusion density in the SVP occurred (p = 0.33). In contrast, during hypoxia, perfusion density in the SVP significantly increased from 34.4 AE 3.0a.u.to 37.1 AE 2.2 a.u. (p < 0.001), while it remained stable in the DCP (p = 0.25). A significant increase in retinal vessel diameters was found (p < 0.01). Systemic oxygen saturation correlated negatively with perfusion density in the SVP and the DCP and retinal vessel diameters (p < 0.005 each). Conclusion:Our results show that systemic hyperoxia induces a significant decrease in vessel density in the DCP, while hypoxia leads to increased vessel density limited to the SVP. These results indicate that the retinal circulation shows the ability to adapt its blood flow to metabolic changes with high local resolution dependent on the capillary plexus.

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Decreased retinal nerve fiber and choroidal thickness in chronic rhinosinusitis

Cited by 2 publications

References 29 publications

Ocular microvascular complications in diabetic retinopathy: insights from machine learning

Ocular microvascular complications in diabetic retinopathy: insights from machine learning

Effect of hyperoxia and hypoxia on retinal vascular parameters assessed with optical coherence tomography angiography

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