Decreased platelet aggregation of platelet concentrate during storage recovers in the body after transfusion

Abstract

These results suggest that the observed decreased in PLT aggregation after storage can improve in the body after transfusion, and transfused PLTs have similar aggregation ability compared to the PLTs derived from the patient.

Effects of storage duration and volume on the quality of leukoreduced apheresis‐derived platelets: implications for pediatric transfusion medicine

“…Despite impaired aggregation in vitro, transfusion of PLTs with metabolic derangements accrued over 5 days of storage has resulted in recovery of PLT function in vivo 18,19 . Similarly, decreases in pH below 6.2 were not associated with any deficit of in vivo PLT recovery or survival 20 .…”

Comparative in vitro evaluation of apheresis platelets stored with 100% plasma or 65% platelet additive solution III/35% plasma and including periods without agitation under simulated shipping conditions

“…A number of reports have shown that in vitro function assays are reversed after transfusion of PLT stored in 100% plasma to recipients. Noteworthy, it has been shown that the aggregation response was restored after transfusion to thrombocytopenic patients 37,38 . Owens and colleagues 39 determined that 5‐day autologous, stored PLTs “quickly recovered adhesion and aggregability capabilities” upon transfusion to normal, healthy subjects.…”

In vitro evaluation of metabolic changes and residual platelet responsiveness in photochemical treated and gamma‐irradiated single‐donor platelet concentrates during long‐term storage

“…4,5,22 Resuspending PLTs stored in 100 percent plasma by autologous plasma stored separately may improve aggregation response, 22,38,55,73 indicating that reduced PLT aggregation during storage may improve in vivo after transfusion. 74 In PCs with low plasma content, however, PLT aggregation responses are severely diminished and only partly recover in the presence of full plasma or blood. 73 In our study we chose not to introduce additional influence on aggregation results by mechanical stress to PLTs in centrifugation, washing, and resuspending in plasma.…”