Decreased oxidative stress may contribute to the disease process in placenta accreta

Öztaş, Efser; Özler, Sibel; Ergin, Merve; Erel, Özcan; B, Gümüş Güler; At, Çağlar; Yücel, Aykan; Uygur, Dilek; Danışman, Nuri

doi:10.3906/sag-1605-141

Cited by 15 publications

(4 citation statements)

References 26 publications

(32 reference statements)

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“…It remains unclear, by which mechanism PAS modulates VWF expression. Placental hypoxia-due to an implantation of the placenta on a uterine scar-has been discussed as one factor that stimulates increased placental invasiveness [24][25][26]. It might also play a role in PAS-induced neoangiogenesis.…”

Section: Discussionmentioning

confidence: 99%

Placenta Percreta Presents with Neoangiogenesis of Arteries with Von Willebrand Factor-Negative Endothelium

et al. 2021

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In placenta percreta cases, large vessels are present on the precrete surface area. As these vessels are not found in normal placentation, we examined their histological structure for features that might explain the pathogenesis of neoangiogenesis induced by placenta accreta spectrum disorders (PAS). In two patients with placenta percreta (FIGO grade 3a) of the anterior uterine wall, one strikingly large vessel of 2 cm length was excised. The samples were formalin fixed and paraffin-embedded. Gomori trichrome staining was used to evaluate the muscular layers and Weigert-Van Gieson staining for elastic fibers. Immunohistochemical staining of the vessel endothelium was performed for Von Willebrand factor (VWF), platelet endothelial cell adhesion molecule (CD31), Ephrin B2, and EPH receptor B4. The structure of the vessel walls appeared artery-like. The vessel of patient one further exhibited an unorderly muscular layer and a lack of elastic laminae, whereas these features appeared normal in the vessel of the other patient. The endothelium of both vessels stained VWF-negative and CD31-positive. In conclusion, this study showed VWF-negative vessel endothelia of epiplacental arteries in placenta accreta spectrum. VWF is known to regulate artery formation, as the absence of VWF has been shown to cause enhanced vascularization. Therefore, we suppose that PAS provokes increased vascularization through suppression of VWF. This process might be associated with the immature vessel architecture as found in one of the vessels and Ephrin B2 and EPH receptor B4 negativity of both artery-like vessels. The underlying pathomechanism needs to be evaluated in a greater set of patients.

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Section: Discussionmentioning

confidence: 99%

Placenta Percreta Presents with Neoangiogenesis of Arteries with Von Willebrand Factor-Negative Endothelium

et al. 2021

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“…However, on the placenta accreta spectrum, there was a decrease in the level of oxidative stress, which is probably related to a decrease in the concentration of antio-angiogenic factor, sFlt-1. 25 Su et al, reported that aspirin which is usually used as a preeclamptic prophylaxis, has a suppressive effect on sFlt-1. 26 Therefore from these findings it can be suggested that suppression of sFlt-1 will increase placental invasion and stimulate placental angiogenesis.…”

Section: Discussionmentioning

confidence: 99%

Soluble FMS-Like Tyrosine Kinase: Role in placenta accreta spectrum disorder

et al. 2021

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Background: Placenta accreta is a pregnancy condition where the placenta's blood vessels attach too deeply to the uterine wall. Incidence of placenta accreta is increasingly seen today as the rate of cesarean section increases, however, the exact pathophysiology of this condition is still not fully understood. Soluble fms-like tyrosine kinase-1 (sflt-1) as a protein produced by the placenta was found to be decreased in placenta accreta, Therefore we aim to see if sflt-1 has a role in the development of placenta accreta. Methods: This study involved 40 samples from patients that had been diagnosed with placenta accreta spectrum disorder (case group), and 40 samples from patients with normal pregnancies (control group) at Rumah Skit Umum Pusat H.Adam Malik (RSUP) Haji Adam Malik Medan, in Indonesia. Diagnosis of placenta accreta syndrome was based on Placenta Accreta Spectrum Score (PAS), and International Federation of Gynecology and Obstetrics (FIGO) classification of placenta accreta spectrum disorder.Analyses were performed by independent t-test, man Whitney U test, and Kruskal-Wallis analysis test, with a P-value <0.05 considered as statistically significant (95%CI). Results: Based on this study, we found that the sFlt-1 level in the case group was lower than the control group. Data analysis using the Kruskal-Wallis test showed that there was a difference in sFlt-1 levels in this study group (p = 0.02), which was further evaluated with post hoc analysis using Mann. Whitney U test. The results indicated that there were significant differences between the control and PAS 0, PAS1, and PAS 2 (p = 0.043; p = 0.002; p = 0.03). Conclusion: sFlt-1 levels decreased in placental invasive pregnancies compared to normal pregnancies, however, this still needs to be investigated further in a multi-center study, considering that sFlt-1 levels are also influenced by ethnicity and other conditions that cannot be excluded in this study.

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“…Oxidative stress is caused by an increased production and insufficient elimination of ROS. Although the underlying exact mechanism has not been fully discovered, oxidative stress is thought to have a significant function in the pathogenesis of many disorders, such as cardiovascular diseases, hypertension, Parkinson's disease, and Alzheimer's disease (13)(14)(15) .…”

Section: Discussionmentioning

confidence: 99%

“…diseases, such as coronary artery disease (CAD) (13)(14)(15) . It was demonstrated that lowering heart rate reduces the formation of ROS in rats (16) .…”

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confidence: 99%

Resting Heart Rate is Not Associated with Oxidative Stress in Healthy Adults

Baysal¹

2019

Kosuyolu Heart Journal

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Introduction: Although resting heart rate (RHR) and oxidative stress are risk factors for cardiovascular morbidity and mortality, the association between them has not been fully understood. The aim of the present study was to investigate the relationship between RHR and oxidative/antioxidative stress markers. Patients and Methods: The study consisted of 56 healthy volunteers (33 males; mean age: 44.1 ± 9.0 years). Subjects were divided into two groups according to heart rate quartiles: lower two quartiles as group 1 (n= 29) and upper two quartiles as group 2 (n= 27). We measured total oxidant status (TOS), total antioxidant capacity (TAC), oxidative stress index (OSI), and ceruloplasmin (CP) levels of subjects. Results: There was no any significant difference in baseline clinical characteristics and laboratory measurements between the groups (p> 0.05 for all variables). Mean RHRs were 71.3 ± 4.6 in group 1 and 82.4 ± 4.1 in group 2. The TAC, TOS, OSI, and CP levels were similar between the two groups (p> 0.05 for all variables). We did not detect any significant association between RHR and oxidative/antioxidative parameters. Conclusion: RHR was not associated with TOS, TAC, OSI, and CP levels in our study.

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Decreased oxidative stress may contribute to the disease process in placenta accreta

Cited by 15 publications

References 26 publications

Placenta Percreta Presents with Neoangiogenesis of Arteries with Von Willebrand Factor-Negative Endothelium

Placenta Percreta Presents with Neoangiogenesis of Arteries with Von Willebrand Factor-Negative Endothelium

Soluble FMS-Like Tyrosine Kinase: Role in placenta accreta spectrum disorder

Resting Heart Rate is Not Associated with Oxidative Stress in Healthy Adults

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