BACKGROUND: The prevalence of anaemia is higher among women, including pregnant women. The estimation was about 24.8% of the population in the world suffering anaemia. Anaemia during pregnancy is a big problem because it can contribute morbidity and mortality, either in mother or newborn. The impacts of anaemia during pregnancy included post-partum haemorrhage, low birth weight (LBW), preterm delivery, and low Appearance, Pulse, Grimace, Activity, Respiration (APGAR) score. AIM: This study aimed to determine the correlation between haemoglobin concentration during pregnancy and the outcome of mothers and newborns. METHODS: It was a cohort study that included 200 pregnant women in second or third trimester at antenatal care of Sundari General Hospital Outpatient Clinic on February until September 2018. The participants were interviewed using a questionnaire, and their blood was checked to measure haemoglobin concentration using portable Easy Touch Hemoglobinometer. In the next three until six months, the following investigation was conducted to assess the maternal and neonatal outcome. RESULTS: The result of this study showed among the maternal outcome, only antepartum haemoglobin concentration had a statistically significant correlation with the haemoglobin concentration during pregnancy (p < 0.05), meanwhile, among the neonatal outcome. LBW was the only factor that statistically significantly correlated to the haemoglobin concentration during pregnancy (p < 0.05). CONCLUSION: We can conclude that once anaemia occurs in pregnant women, then the women kept suffering from anaemia with its correlation was statistically significant. Keywords : hemoglobin concentration, anemia during pregnancy, maternal, neonatal outcome
BACKGROUND:Nowadays, successful treatment of cancer is not only measured by 5-years survival rate, but also by the patient’s quality of life (QOL). Delayed in the seeking of cancer treatment resulted in high morbidity and impact on the quality of life.AIM:This study aims to assess the QOL of patients with gynecologic cancer after therapy. The results of this research can be used as a basis for cancer treatment that should be holistic, not only to eradicate the disease, but also improve QOL.METHODS:A total of 47 respondents who went to the Department of Oncology, Haji Adam Malik Hospital Medan from May to October 2015 were asked to fill out the FACT-G questionnaire for the QOL assessment. The patient’s personal and disease data was taken from the medical records. The data were analysed statistically by one-way ANOVA test.RESULTS:The results showed that the physical, social, emotional and functional of cancer patients were not much different based on the variables studied. The QOL was higher in patients with endometrial cancer compared with other types of cancer. The QOL was also higher in patients who had completed treatment (> 6 months) and early-stages cancer. There was no statistical difference between the QOL of patients with gynecologic cancer based on therapeutic modalities, duration of treatment and the stage of disease (p > 0.05).CONCLUSION:This current study found the QOL, physical, and emotional complaints are still encountered.
The Asian Society of Gynecologic Oncology International Workshop 2018 on gynecologic oncology was held in the Ajou University Hospital, Suwon, Korea on the 24th to 25th August 2018. The workshop was an opportunity for Asian doctors to discuss the latest findings of gynecologic cancer, including cervical, ovarian, and endometrial cancers, as well as the future of fertility-sparing treatments, minimally invasive/radical/debulking surgery, radiotherapy, chemotherapy, targeted therapy, and immunotherapy. Clinical guidelines and position statement of Asian countries were presented by experts. Asian clinical trials for gynecologic cancers were reviewed and experts emphasized the point that original Asian study is beneficial for Asian patients. In Junior session, young gynecologic oncologists presented their latest research on gynecologic cancers.
Background: Endometriosis is a benign disease that has malignant properties such as genetic polymorphism, loss control of cell proliferation, infiltration, and local spread or to distant places. Several endometriosis studies linking endometrioma/ ovarian endometriosis with an increased risk of ovarian malignancy give rise to a transformation phenomenon of endometriotic cysts into malignancy. Bax is a pro apoptotic protein whose expression decreases in a malignancy. This decrease is related to the poor prognosis of endometrioma and ovarian carcinoma. This study was aimed to identify the expression and the difference of Bax expression between endometrioma and ovarian carcinoma.Materials and Methods: Fifty of paraffin blocks of endometrioma tissue and ovarian carcinoma (serous, mucinous, clear cell, and endometrioid type) were examined by immunohistochemical using Bondmax Full Automatic with specific monoclonal antibody to identify Bax expression. The difference of Bax expression score between endometrioma tissue and ovarian carcinoma was tested by Mann-Whitney test with significant value was set at p<0.05.Results: This study found that mean Bax expression score in endometrioma tissue and ovarian carcinoma was 3.88 and 3.72. No difference of Bax expression between endometrioma tissue and ovarian carcinoma (p>0.05). No difference of Bax expression between the clinical stages and histopathological types of ovarian carcinoma (p>0.05).Conclusion: There are no statistically significant difference in Bax protein expression in ovarian cancer and endometrioma.Keywords: Bax expression, endometrioma, ovarian carcinoma, apoptotic resistance
Latar belakang: Kanker ovarium memiliki angka mortalitas yang cukup tinggi dikarenakan gejalanya yang tidak spesifik, sering ditemukan pada stadium lanjut, dan belum adanya metode deteksi dini yang sudah terbukti. Untuk menilai keberhasilan terapi penyintas kanker ovarium, tidak hanya dinilai dari aspek klinis tetapi juga dinilai dari kualitas hidup penyintas kanker ovarium yang penilaiannya berdasarkan skala fungsional dan skala gejala dalam kuesioner EORTC QLQ C30 dan EORTC QLQ OV28. Metode: Penelitian ini menggunakan desain penelitian cross sectional, menggunakan data primer dari hasil wawancara dengan kuesioner EORTC QLQ C30 dan EORTC QLQ OV28 serta data sekunder yang berasal dari rekam medik di RSUP Haji Adam Malik Medan tahun 2017 - 2018. Sampel penelitian dipilih dengan metode total sampling dari seluruh data rekam medik yang memenuhi kriteria penelitian. Hasil: Hasil penelitian ini didapatkan kualitas hidup global penyintas kanker ovarium 89.36% adalah baik, dan 10.64% adalah sedang serta tidak ada yang memiliki kualitas hidup buruk. Namun, didapatkan adanya gangguan pada skala fungsional berupa: fungsi emosional, fungsi kognitif, fungsi seksual, dan sikap terhadap penyakit, serta adanya permasalahan pada skala gejala berupa: kelelahan, nyeri, neuropati perifer, dan gejala menopause. Didapatkan juga tidak ada hubungan karakteristik usia, jenis histopatologis, stadium, lama terapi dengan kualitas hidup penyintas kanker ovarium, namun terdapat hubungan antara jenis terapi dengan kualitas hidup penyintas kanker ovarium. Kesimpulan: Kualitas hidup penyintas kanker ovarium secara global adalah baik. Kata Kunci: Kualitas Hidup, Penyintas Kanker Ovarium, EORTC QLQ C-30, EORTC QLQ OV-28 Abstract Background: Ovarian cancer has a high mortality rate due to nonspecific symptoms, often found at an advanced stage, and also the absence of proven early detection methods. To assess the success of ovarian cancer survivors therapy, it is not only assessed from the clinical aspect but also from the quality of life of ovarian cancer survivors which is based on the functional and symptom scale in the EORTC QLQ C30 and EORTC QLQ OV28 questionnaires. Methods: This study used a cross-sectional study design, using primary data from interviews with the survivors based on the questionnaire EORTC QLQ C30 and EORTC QLQ OV28 as well as secondary data derived from medical records at Haji Adam Malik General Hospital Medan in 2017 - 2018. The research sample was used with a total sampling method from all medical record data that fulfill the research criteria. Result: The quality of life of ovarian cancer survivors is generally good (89.36%), meanwhile the rest is moderate (10.64%) without the poor quality of life. However, there are disorders on the functional scale in the form of emotional function, cognitive function, sexual function, and attitude toward disease. Likewise on the scale of symptoms, there are problems including: fatigue, pain, peripheral neuropathy, and menopausal symptoms. Conclusion: The quality of life of ovarian cancer survivors globally is good. Keywords: Quality of Life, Ovarian Cancer Survivors, EORTC QLQ C-30, EORTC QLQ OV-28
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