Resting Heart Rate is Not Associated with Oxidative Stress in Healthy Adults

Abstract

Introduction: Although resting heart rate (RHR) and oxidative stress are risk factors for cardiovascular morbidity and mortality, the association between them has not been fully understood. The aim of the present study was to investigate the relationship between RHR and oxidative/antioxidative stress markers. Patients and Methods: The study consisted of 56 healthy volunteers (33 males; mean age: 44.1 ± 9.0 years). Subjects were divided into two groups according to heart rate quartiles: lower two quartiles as group 1 (n= 29) and upper two quartiles as group 2 (n= 27). We measured total oxidant status (TOS), total antioxidant capacity (TAC), oxidative stress index (OSI), and ceruloplasmin (CP) levels of subjects. Results: There was no any significant difference in baseline clinical characteristics and laboratory measurements between the groups (p> 0.05 for all variables). Mean RHRs were 71.3 ± 4.6 in group 1 and 82.4 ± 4.1 in group 2. The TAC, TOS, OSI, and CP levels were similar between the two groups (p> 0.05 for all variables). We did not detect any significant association between RHR and oxidative/antioxidative parameters. Conclusion: RHR was not associated with TOS, TAC, OSI, and CP levels in our study.