“…Cushing's syndrome is a pathological model of insulin resistance produced by chronically high Cortisol levels {Nosadini, Del Prato, Hengo, Valerio, Muggeo, Opocher, Mantero, Duner, Marescotti, Mollo and Belloni 1983;Karnieli, Cohen, Barzilai, Ish Salom, Armoni, Rafaelov and Barzilai 1985). In isolated adipocytes from patients with this syndrome we have previously observed a decreased sensitivity to the antilipolytic action of insulin without changes in the total number of insulin receptors (IR)s on the cell surface (Calle, Carranza, Simon, Torres and Mayor 1987). Other laboratories also failed to detect insulin receptor defects in erythrocytes and monocytes from hypercortisolemic patients, despite the presence in these patients of a clear situation of insulin resistance (Nosadini et al 1983;Muggeo, Saviolakis, Wachslicht-Rodbard and Roth 1983).…”