Insulin Receptor mRNA Levels are Modulated in a Tissue-Specific Manner in Cushing's Syndrome Patients

The administration of 5 x 10(-6) mol/l dexamethasone transiently increased insulin receptor (IR) mRNA levels in U-937 human promonocytic cells, which reached the maximum level at 15 h of treatment. Dexamethasone treatment did not affect the IR mRNA half-life (approximately 4 h), suggesting that the increase is regulated at the transcriptional level. The stimulatory action of dexamethasone was not prevented by the simultaneous presence of the protein synthesis inhibitor cycloheximide, indicating that the induction of IR gene transcription occurs as a direct response to the action of the synthetic glucocorticoid. Finally, the A isoform (lacking exon 11) was found to be the only IR isoform present in both untreated and dexamethasone treated-U-937 cells.

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Effect of dexamethasone on insulin receptor mRNA levels, RNA stability and isotype RNA pattern in U-937 human promonocytic cells

Leal

Aller

Calle

1996

J Endocrinol Invest

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Transcriptional inhibition of the human insulin receptor gene by aldosterone

Calle

Campión

Garcı́a-Arencibia

et al. 2003

The Journal of Steroid Biochemistry and Molecular Biology

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Inhibition by aldosterone of insulin receptor mRNA levels and insulin binding in U-937 human promonocytic cells

Campión

Maestro

Mata

et al. 1999

The Journal of Steroid Biochemistry and Molecular Biology

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Insulin Receptor mRNA Levels are Modulated in a Tissue-Specific Manner in Cushing's Syndrome Patients

Cited by 5 publications

References 4 publications

Effect of dexamethasone on insulin receptor mRNA levels, RNA stability and isotype RNA pattern in U-937 human promonocytic cells

Effect of dexamethasone on insulin receptor mRNA levels, RNA stability and isotype RNA pattern in U-937 human promonocytic cells

Transcriptional inhibition of the human insulin receptor gene by aldosterone

Inhibition by aldosterone of insulin receptor mRNA levels and insulin binding in U-937 human promonocytic cells

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