2005
DOI: 10.1002/dmrr.567
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Is insulin resistance caused by defects in insulin's target cells or by a stressed mind?

Abstract: The importance of understanding insulin action is emphasized by the increasing prevalence of insulin resistance in various populations and by the fact that it plays an important pathophysiological role in many common disorders, for example, diabetes, obesity, hypertension and dyslipidemia. The primary factors responsible for the development of insulin resistance are so far unknown, although both genetic and environmental factors are involved. The genetic defects responsible for the common forms of insulin resi… Show more

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Cited by 32 publications
(31 citation statements)
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“…However, the relationships are complex and both hyper-and hypocortisolism may arise as a consequence of fetal programming of the HPA axis during intrauterine life. Nonetheless, although not scrutinised in our present work, such a relationship between fetal events and adult-onset diabetes is intriguing, given the role of glucocorticoids and stress in the pathogenesis of type 2 diabetes [19].…”
Section: Discussionmentioning
confidence: 78%
“…However, the relationships are complex and both hyper-and hypocortisolism may arise as a consequence of fetal programming of the HPA axis during intrauterine life. Nonetheless, although not scrutinised in our present work, such a relationship between fetal events and adult-onset diabetes is intriguing, given the role of glucocorticoids and stress in the pathogenesis of type 2 diabetes [19].…”
Section: Discussionmentioning
confidence: 78%
“…In addition, release of adrenaline from the adrenal medulla is regulated largely by autonomic nerve activity. Sympathoadrenal activation will have profound metabolic effects including insulin resistance (3,13). For more long-term communication the brain can use the hypthalamo-pituitary hormonal systems and other neurohormonal pathways.…”
Section: Page 5 Of 28mentioning
confidence: 99%
“…Nonetheless, the ability of counter-regulatory hormones, including glucagon, adrenaline, cortisol and growth hormone, to increase blood glucose can contribute to insulin resistance and development of type 2 diabetes if there is an inappropriately large response (13) Insulin resistance in the pathobiology of type 2 diabetes Insulin resistance is an important component of the pathophysiological processes that underlies the development of type 2 diabetes, and it is likely to play a role in development of other conditions such as dyslipidemia, hypertension and atherosclerosis.…”
Section: Page 5 Of 28mentioning
confidence: 99%
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