Decrease in rate of ATP synthesis of Isolated rat heart mitochondria induced by dietary erucic acid

Houtsmuller, U.M.T.; Struijk, C.B.; Beek, A. van der

doi:10.1016/0005-2760(70)90025-1

Cited by 98 publications

(35 citation statements)

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“…riches en acides eicosénoïque (C20.lco9) et érucique (C22: j 0J9) provoquent, chez le jeune rat, une stéatose cardiaque dès les premières 24 h de mise au régime [2, 10,18]. Il s'agit surtout d'une accumulation intracellulaire de triglycérides qui renferment jusqu'à 50% des ces monoènes à très longue chaîne, tra-52 rats mâles Wistar SPF pris au sevrage (âge: 3 semaines) sont repartis en cages individuelles et reçoivent pendant 3 jours une provende commerciale contenant 6-10% de lipides dépourvus d'acides gras à très longue chaîne en C2(J et C22.…”

Section: Les Huiles De Colza ( Brassica Napus) Et De Navette ( Brassiunclassified

Influence des huiles de colza et de canbra sur les lipides plasmatiques du rat<sup>1</sup>

et al. 1974

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Rapeseed oil fed to male weanling rats as 15% by weight of the diet for 2 months does not influence the plasma content of triglycerides (TG), phospholipids (PL), nonesterified fatty acids (NEFA) and cholesterol esters (CE), as compared to peanut oil and canbra oil (‘zero erucic acid’ rapeseed oil). However, the fatty acid spectra are changed: erucic acid and eicosénoïque acid from dietary rapeseed oil are mainly incorporated in TG and NEFA, less in PL and practically not at all in CE. Feeding time has little effect. Therefore, the immediate but temporary cardiac steatosis which is obtained in weanling rats fed rapeseed oil cannot be explained by modifications of the plasma TG or NEFA concentration and/or their fatty acid composition. Rapeseed and canbra oil increase the percentages of ω3-polyunsaturated fatty acids and of nervonic acid in plasma PL.

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Section: Les Huiles De Colza ( Brassica Napus) Et De Navette ( Brassiunclassified

Influence des huiles de colza et de canbra sur les lipides plasmatiques du rat<sup>1</sup>

et al. 1974

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“…H o utsm uller et al [14] observed a decreased ADP/O-ratio in isolated heart mitochondria of RSO fed rats (2.52 vs. control 2.70). The effect is maximal after about 3 days of feeding and thereafter decreases slowly; this course roughly parallels the appearance of lipidosis in the heart.…”

Section: Experiments 3 Rapeseed Oh Absorption Capacity O F Ratsmentioning

confidence: 99%

Digestibility, Efficiency and other Metabolic Effects of Dietary Rapeseed Oil in Rats

Hornstra¹

1972

Ann Nutr Metab

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Rats were fed diets containing 60 cal% rapeseed oil (RSO) or sunflowerseed oil (SSO) for periods up to 64 weeks. When the animals were allowed to eat ad libitum, the food consumption in the RSO group was significantly lower than in the SSO group. It was shown that the RSO diet is less readily digested than the SSO diet. This is due solely to the lower digestion coefficient of the RSO and of its erucic acid fraction in particular, which can be explained by its chain length. The digestion coefficient of the non-fat calories is equal in both groups. The digestion capacity is not a limiting factor in RSO digestion. The absorbed erucic acid is almost totally metabolized. Rats fed a RSO-containing diet utilize the digested calories less efficiently than animals offered an SSO diet. Moreover, their oxygen consumption and water-vapour release are higher. It is assumed that the lower efficiency of the RSO diet is caused by a slightly uncoupled oxidative phosphorylation and a greater heat increment.

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“…5,6] but it has not been proved that heart cells are able to do this. In addition it has been shown that heart mitochondria from rats which have been fed with rapeseed-oil oxidize cu-oxoglutarate and succinate at a lower rate [7] . A direct inhibitory effect of erucylcarnitine on palmitate oxidation has been also reported…”

Section: Introductionmentioning

confidence: 99%

Erucic acid oxidation by beating heart cells in culture

Pinson¹,

Padieu²

1974

FEBS Letters

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Decrease in rate of ATP synthesis of Isolated rat heart mitochondria induced by dietary erucic acid

Cited by 98 publications

References 1 publication

Influence des huiles de colza et de canbra sur les lipides plasmatiques du rat<sup>1</sup>

Influence des huiles de colza et de canbra sur les lipides plasmatiques du rat<sup>1</sup>

Digestibility, Efficiency and other Metabolic Effects of Dietary Rapeseed Oil in Rats

Erucic acid oxidation by beating heart cells in culture

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