Decrease in mast cells in oral squamous cell carcinoma: Possible failure in the migration of these cells

Oliveira-Neto, Helenisa Helena; Leite, Angélica Ferreira; Costa, Nádia Lago; Alencar, Rita C.G.; Lara, Vanessa Soares; Silva, Tarcı́lia Aparecida; Leles, Cláudio Rodrigues; Mendonça, Francisco Elismauro; Batista, Aline Carvalho

doi:10.1016/j.oraloncology.2006.05.004

Cited by 54 publications

(60 citation statements)

References 31 publications

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“…MC density may be highest initially in tumorigenesis (21), and poorly differentiated tumors had fewer MCs than welldifferentiated OSCCs (22), supporting the concept that SCF from more differentiated OSCCs may stimulate local MC differentiation and therefore be associated with a good prognosis. Reduced MC density in OSCCs with poor prognosis may also reflect microenvironmental changes during squamous epithelial carcinogenesis, making it more permissive to neoplastic cell proliferation (23). Thus, MCs may modulate immune responses, inhibit cancer growth or be a secondary phenomenon related to cancer cell differentiation and production of MC growth factors.…”

Section: Stromal Cells (Red Arrows) At the Invasive Front Of Carcinmentioning

confidence: 99%

Low Mast Cell Density Predicts Poor Prognosis in Oral Squamous Cell Carcinoma and Reduces Survival in Head and Neck Squamous Cell Carcinoma

Attramadal

Kumar

Gao

et al. 2016

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Abstract. Background: The cellular composition of the tumor microenvironment (TME) at the invading front of oral squamous cell carcinomas (OSCCsThe growth of oral squamous cell carcinoma cells is influenced by its stroma. Stromal cells such as mast cells (MCs), cancer-associated fibroblasts (CAFs), tumorassociated macrophages (TAMs), endothelial cells, pericytes, smooth muscle cells and lymphocytes promote tumor growth, local infiltration, proliferation, neovascularization and escape from immune defense (1). Such cancer-amended stroma is referred to as the tumor microenvironment (TME) (2), and is probably as important as the cancer itself in facilitating cancer cell invasion and metastasis. In the current study of early-stage oral squamous cell carcinomas (OSCCs), we examined the significance of MCs, CAFs, TAMs and endothelial cells in the TME of the invasive front, and their influence on disease recurrence. The MC findings were further explored in a larger cohort of patients with head and neck squamous cell carcinoma.MCs are especially present in surface mucosa such as the skin, bronchial tract, lungs and digestive tract, conjunctiva, nose and mouth, and are best known for their role in allergic immune reactions (3). The TME in OSCC contains more MCs than normal oral mucosa (4), but their role in TME is intricate and poorly understood. These MCs may promote cancer growth by stimulating angiogenesis and tissue remodeling, but also exert anticancerous effects, depending on cofactors and cell location (5).CAFs represent a common functional state of cancerstimulated mesenchymal cells. Their cell of origin is 5499

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Section: Stromal Cells (Red Arrows) At the Invasive Front Of Carcinmentioning

confidence: 99%

Low Mast Cell Density Predicts Poor Prognosis in Oral Squamous Cell Carcinoma and Reduces Survival in Head and Neck Squamous Cell Carcinoma

Attramadal

Kumar

Gao

et al. 2016

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“…Immune-inflammatory cell response in the tumor microenvironment is regulated by a heterogeneous family of tumor infiltrating lymphocytes (TILs), which may have a dual function of inhibiting or promoting tumor growth and progression (1,2). Many reasons account for the failure of host immune systems to control tumor growth, such as the development of tumor variants that escape immune recognition or down-regulation of the major histocompatibility complex class molecules.…”

Section: Introductionmentioning

confidence: 99%

T regulatory cell markers in oral squamous cell carcinoma: Relationship with survival and tumor aggressiveness

Moreira

Fulgêncio²,

Mendonça³

et al. 2010

Oncology Letters

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Abstract. Tumor-infiltrating lymphocytes (TILs) are a heterogeneous cell family which plays an important role in tumorassociated immune response. Of these, T regulatory (Treg) cells have also been shown to inhibit anti-tumor response. We aimed to evaluate the expression of T regulatory cell markers (CD4, CD25, CTLA-4 and FoxP3) in samples of oral cavity squamous cell carcinoma (OCSCC) and lip SCC (LSCC) by immunohistochemistry. The relationship of Treg markers with survival data and the proliferative index were also evaluated. We observed similar numbers of CD4-, CD25-and FoxP3+ cells in OCSCC and LSCC. On the other hand, numbers of CTLA-4 + cells were significantly lower in OCSCC than in LSCC. OCSCC samples with high numbers of CD4 exhibited a high proliferative index, while samples with high CTLA-4 counts demonstrated a low tumoral proliferative index. A log-rank test showed that patients with OCSCC that presented high counts of CD4 showed a significantly decreased survival compared with patients with low cell counts. In contrast, high CD25 + cell counts were associated with increased survival. Our results suggest an association of CD4 with poor prognosis, while CD25 expression is related with favorable prognosis. These findings result from the heterogeneity of TIL subsets that display an antagonistic role in tumor immune cell response.

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“…Oliveira Neto et al 8 showed a reduction in the number of mast cells in premalignant and malignant lesions of the oral cavity and suggested that this fact may be associated with a failure in the migration of these cells, possibly reflecting an important modification in the microenvironment during tumor initiation and progression.…”

Section: Discussionmentioning

confidence: 99%

“…7 Recent data suggest that mast cells may play opposing roles in tumor biology and that the microenvironment may polarize these cells to render either a promoting or inhibiting effect on tumors. 1,8 Angiogenesis, an important prognostic factor in many tumors, is a complex event mediated by angiogenic factors released by the neoplastic cells or by the host's immune cells. Among the host's immune cells, mast cells have been associated with tumor progression by promoting angiogenesis.…”

Section: 3mentioning

confidence: 99%

Comparação entre a concentração de mastócitos em carcinomas espinocelulares da pele e da cavidade oral

Parizi¹,

Barbosa

Parizi

et al. 2010

An. Bras. Dermatol.

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FUNDAMENTS:The lethality of squamous cell carcinomas (SCC) of the skin is considered low. SCC in the mouth is usually associated with poor prognosis. Current evidence suggests that mast cells in the normal tissue contribute to the tumorigenesis of SCC, probably by promoting angiogenesis. OBJECTIVE: The aim of this study was to compare the concentration of mast cells in SCC of the mouth and skin and evaluate whether there is a correlation with the degree of differentiation of these tumors. MATERIAL AND METHODS: Thirty cases of SCC of the skin and 34 of the mouth were investigated. Toluidine blue staining was used to identify mast cells in blocks containing the central portion of the neoplasm. RESULTS: A concentration of between 0 and 10 mast cells was found in one single case of SCC of the skin and there were no cases of SCC of the mouth with concentrations of mast cells in the tumor >201. In the majority of cases of SCC of the mouth (47%; n=16), mast cell concentration was between 0 and 10, with a concentration >51 mast cells in 80% of cases of SCC of the skin. All the cases of SCC of the mouth with a concentration of mast cells between 100 and 200 and 80% of those with a concentration of 51-99 were located on the lip. The concentration of mast cells was unrelated to the degree of differentiation of the tumor. CONCLUSION: The concentration of mast cells is lower in SCC of the mouth except when the tumor is located on the lip. This may reflect a lower need for cell activation in the microenvironment to improve vascularization in oral cancer.

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Decrease in mast cells in oral squamous cell carcinoma: Possible failure in the migration of these cells

Cited by 54 publications

References 31 publications

Low Mast Cell Density Predicts Poor Prognosis in Oral Squamous Cell Carcinoma and Reduces Survival in Head and Neck Squamous Cell Carcinoma

Low Mast Cell Density Predicts Poor Prognosis in Oral Squamous Cell Carcinoma and Reduces Survival in Head and Neck Squamous Cell Carcinoma

T regulatory cell markers in oral squamous cell carcinoma: Relationship with survival and tumor aggressiveness

Comparação entre a concentração de mastócitos em carcinomas espinocelulares da pele e da cavidade oral

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