Decrease in cell-mediated immunity by surgical intervention and its prevention by levamisole

“…Following the reports that levamisole enhanced certain immune functions [14], especially in cancer patients whose immune function had been highly suppressed either by tumor burden or by therapies [19,29,30], the possible application of levamisole for tumor therapy was proposed. The studies on human patients and experimental animals have resulted in mixed and sometimes contradictory findings [17].…”

Section: Reprint Requests Should Be Addressed To H Shaumentioning

confidence: 99%

Regulation of human natural killing by levamisole

Shau

Dawson

1982

Cancer Immunol Immunother

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The effect of levamisole on human natural killing (NK) has been studied. In short-term chromium release assays, levamisole at a concentration of 10(-3) M was inhibitory to NK when present in the assays. Pretreatment of NK effector cells and K562 target cells with levamisole separately indicated that the effect was on effector cell activity and was not due to any change in target cell susceptibility. Inactivation of the effector cells required greater than 4 h pretreatment with levamisole if NK activity was subsequently tested in the absence of the drug. Pretreatment with levamisole for up to 19 h had no effect on the lymphocyte proliferative response to phytohemagglutinin (PHA). NK activity of drug-inactivated effector cells recovered after further incubation in levamisole-free medium. Levamisole at 10(-4) M or less had no effect on NK either by pretreatment or by its presence in the NK assays.

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Effect of operation on peripheral lymphocyte counts and production of adenosine triphosphate (ATP) in cancer patients

Mukherjee¹,

Sahasrabuddhe

1982

Journal of Surgical Oncology

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Lymphocyte bioenergetics in cancer patients undergoing surgery is largely unexplored. The effect of surgery on total lymphocyte counts and adenosine triphosphate (ATP) production is reported. Lymphocyte ATP was assayed by the coupled enzymatic method using hexokinase and glucose 6-phosphate dehydrogenase and lymphocyte counts were calculated from total leukocyte counts and differential counts. Lymphocyte ATP assay and counts were carried out in 13 patients pre- and postoperatively, and lymphocyte counts were scored in six more patients similarly. In 69% of the patients lymphocyte ATP production was depressed postoperatively, and this condition appeared to be associated with cancer spread and immunosuppressive tumors. Postoperative increase in lymphocyte ATP was observed following hysterectomy, colostomy, and also after blood transfusion. The significance of the findings are discussed. Changes in postoperative lymphocyte counts correlated with lymphocyte ATP in 62% of the cases.

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Decrease in cell-mediated immunity by surgical intervention and its prevention by levamisole

Cited by 13 publications

References 11 publications

Augmentation of the Antibody Response by Lipoic Acid in Mice II. Restoration of the Antibody Response in Immunosuppressed Mice

Augmentation of the Antibody Response by Lipoic Acid in Mice II. Restoration of the Antibody Response in Immunosuppressed Mice

Regulation of human natural killing by levamisole

Effect of operation on peripheral lymphocyte counts and production of adenosine triphosphate (ATP) in cancer patients

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