Declarative Memory Performance Is Associated With the Number of Sleep Spindles in Elderly Women

Seeck‐Hirschner, Mareen; Baier, Paul Christian; Weinhold, Sara Lena; Dittmar, Manuela; Heiermann, Steffanie; Aldenhoff, Josef B.; Göder, Robert

doi:10.1097/jgp.0b013e31823033da

Cited by 34 publications

(43 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Relatively few studies have investigated this relationship in older adults (e.g., Rauchs et al., 2008, Seeck-Hirschner et al., 2012) and it may be that the role of spindles in memory consolidation diminishes with age.…”

Section: Discussionmentioning

confidence: 99%

Slow wave sleep and accelerated forgetting

Atherton

Nobre

Lázár

et al. 2016

Cortex

View full text Add to dashboard Cite

We investigated whether the benefit of slow wave sleep (SWS) for memory consolidation typically observed in healthy individuals is disrupted in people with accelerated long-term forgetting (ALF) due to epilepsy. SWS is thought to play an active role in declarative memory in healthy individuals and, furthermore, electrographic epileptiform activity is often more prevalent during SWS than during wakefulness or other sleep stages. We studied the relationship between SWS and the benefit of sleep for memory retention using a word-pair associates task. In both the ALF and the healthy control groups, sleep conferred a memory benefit. However, the relationship between the amount of SWS and sleep-related memory benefits differed significantly between the groups. In healthy participants, the amount of SWS correlated positively with sleep-related memory benefits. In stark contrast, the more SWS, the smaller the sleep-related memory benefit in the ALF group. Therefore, contrary to its role in healthy people, SWS-associated brain activity appears to be deleterious for memory in patients with ALF.

show abstract

Section: Discussionmentioning

confidence: 99%

Slow wave sleep and accelerated forgetting

Atherton

Nobre

Lázár

et al. 2016

Cortex

View full text Add to dashboard Cite

show abstract

“…In children and adults, spindle number and density strongly correlate with IQ scores (106,395,439,847,1038,1039) as well as overnight retention of memories (213,1057,1230). Abnormally large spindles or the absence of spindles were observed in mentally retarded and dyslexic children (93,148,400,455,456,1070,1071).…”

Section: Björn Rasch and Jan Bornmentioning

confidence: 93%

“…In rats, robust increases in sleep spindles (12)(13)(14)(15) Hz) were observed after learning odor-reward associations (354) and after avoidance training (397). Furthermore, indicators of sleep spindle expression consistently correlated with the amount of overnight retention of declarative memories (86,213,214,235,446,562,822,1016,1024,1037,1044,1057). Interestingly, spindle activity (11)(12)(13)(14)(15) Hz) also correlated with signs of overnight lexical integration of newly learned information, suggesting that spindles contribute to the integration of new memories into existing neocortical knowledge networks (1175).…”

Section: Relationship Between Spindles and Memorymentioning

confidence: 97%

About Sleep's Role in Memory

Rasch

Born

2013

Physiological Reviews

2,211

2,026

View full text Add to dashboard Cite

Over more than a century of research has established the fact that sleep benefits the retention of memory. In this review we aim to comprehensively cover the field of "sleep and memory" research by providing a historical perspective on concepts and a discussion of more recent key findings. Whereas initial theories posed a passive role for sleep enhancing memories by protecting them from interfering stimuli, current theories highlight an active role for sleep in which memories undergo a process of system consolidation during sleep. Whereas older research concentrated on the role of rapid-eye-movement (REM) sleep, recent work has revealed the importance of slow-wave sleep (SWS) for memory consolidation and also enlightened some of the underlying electrophysiological, neurochemical, and genetic mechanisms, as well as developmental aspects in these processes. Specifically, newer findings characterize sleep as a brain state optimizing memory consolidation, in opposition to the waking brain being optimized for encoding of memories. Consolidation originates from reactivation of recently encoded neuronal memory representations, which occur during SWS and transform respective representations for integration into long-term memory. Ensuing REM sleep may stabilize transformed memories. While elaborated with respect to hippocampus-dependent memories, the concept of an active redistribution of memory representations from networks serving as temporary store into long-term stores might hold also for non-hippocampus-dependent memory, and even for nonneuronal, i.e., immunological memories, giving rise to the idea that the offline consolidation of memory during sleep represents a principle of long-term memory formation established in quite different physiological systems.

show abstract

“…We were again surprised to see multiple reports of negative correlations between memory and SWS quantity (Lo, Sim, & Chee, 2014; Mazzoni et al, 1999; Seeck-Hirschner et al, 2012; refer back to Section C: Bastien et al, 2003; Buechel et al, 2011; Feinberg et al, 1967; Platt et al, 2011; Scullin, 2013; Spiegel, 1981), though some studies did not show a concomitant experimental sleep effect. One interpretation of negative SWS—cognition correlations is “overactive” synaptic downscaling (Table 1), whereby too much SWS might prune synapses that would otherwise support memory in older adults (Scullin, 2013; cf.…”

Section: Experimental Studies Of Memory Consolidationmentioning

confidence: 95%

Sleep, Cognition, and Normal Aging

Scullin

Bliwise

2015

Perspect Psychol Sci

387

155

View full text Add to dashboard Cite

Sleep is implicated in cognitive functioning in young adults. With increasing age there are substantial changes to sleep quantity and quality including changes to slow wave sleep, spindle density, and sleep continuity/fragmentation. A provocative question for the field of cognitive aging is whether such changes in sleep physiology affect cognition (e.g., memory consolidation). We review nearly a half-century of research studies across 7 diverse correlational and experimental literature domains, which historically have had little crosstalk. Broadly speaking, sleep and cognitive functions are often related in advancing age, though the prevalence of null effects (including correlations in the unexpected, negative direction) in healthy older adults indicates that age may be an effect modifier of these associations. We interpret the literature as suggesting that maintaining good sleep quality, at least in young adulthood and middle age, promotes better cognitive functioning and serves to protect against age-related cognitive declines.

show abstract

Declarative Memory Performance Is Associated With the Number of Sleep Spindles in Elderly Women

Cited by 34 publications

References 43 publications

Slow wave sleep and accelerated forgetting

Slow wave sleep and accelerated forgetting

About Sleep's Role in Memory

Sleep, Cognition, and Normal Aging

Contact Info

Product

Resources

About