Deciphering the modulatory role of apigenin targeting oncogenic pathways in human cancers

Abstract

Cancer is a complicated malignancy controlled by numerous intrinsic and extrinsic pathways. There has been a significant increase in interest in recent years in the elucidation of cancer treatments based on natural extracts that have fewer side effects. Numerous natural product-derived chemicals have been investigated for their anticancer effects in the search for an efficient chemotherapeutic method.Therefore, the rationale behind this review is to provide a detailed insights about the anticancerous potential of apigenin via modulating numerous cell signaling pathways. An ingestible plant-derived flavonoid called apigenin has been linked to numerous anticancerous potential in numerous experimental and biological studies. Apigenin has been reported to induce cell growth arrest and apoptotic induction by modulating multiple cell signaling pathways in a wider range of human tumors including those of the breast, lung, liver, skin, blood, colon, prostate, pancreatic, cervical, oral, and stomach. Oncogenic protein networks, abnormal cell signaling, and modulation of the apoptotic machinery are only a few examples of diverse molecular interactions and processes that have not yet been thoroughly addressed by scientific research. Thus, keeping this fact in mind, we tried to focus our review towards summarizing the apigenin-mediated modulation of oncogenic pathways in various malignancies that can be further utilized to develop a potent therapeutic alternative for the treatment of various cancers.

Chemical Analysis and in Vitro Antiviral Effects of Northeast Türkiye Propolis Samples against HSV‐1

“…The biological activities of some phenolic components have been determined. [41,42] When evaluated from this point of view, it can be expected that a propolis containing a large amount of CAPE will show anti-cancer properties, and a propolis with a high amount of chrysin will exhibit antibacterial properties. [41,42] As a matter of fact, in the study conducted, it was determined that Ardahan propolis with the highest amount of chrysin showed more anti-HSV-1 activity than other samples.…”

“…Gallic acid, protocatechuic acid, p‐ OH benzoic acid, catechin, epicatechin, myricetin, resveratrol and hesperidin were not found in any extract. The biological activities of some phenolic components have been determined [41,42] . When evaluated from this point of view, it can be expected that a propolis containing a large amount of CAPE will show anti‐cancer properties, and a propolis with a high amount of chrysin will exhibit antibacterial properties [41,42] .…”

Targeting Wnt/β-Catenin Pathway by Flavonoids: Implication for Cancer Therapeutics

“…The biological and pharmacological aspects of apigenin have been studied for many years. A growing body of studies have revealed that apigenin can modify the expression of important signaling pathways implicated in the carcinogenesis process, thereby inducing apoptosis [149]. Recent studies have shown that apigenin can reduce different kinds of malignancies, such as prostate, breast, lung, colorectal, liver, leukemia, ovarian, pancreatic, and cervical cancers.…”

A comprehensive view on the apigenin impact on colorectal cancer: Focusing on cellular and molecular mechanisms

“…Apigenin has also been found to induce cell cycle arrest, trigger cell apoptosis and autophagy, stimulate an immune reaction, and suppress metastasis and aggression in multiple human cancers in vitro and in vivo via various biological mechanisms (Pandey et al, 2023;Yan et al, 2017;Zhong et al, 2021;Zhou et al, 2022).…”

“…Apigenin shows an oncolytic effect through apoptosis induction by modulating the quantity of caspases, BAX, Bcl2, p53, etc (Mabrouk Zayed et al, 2022 ). Apigenin also regulates cell cycle advancement by stopping the cycle arrest at G2/M or G0/G1 checkpoint (Pandey et al, 2023 ). In addition, it promotes autophagy, hinders migration and invasion, and deters angiogenesis (Chen et al, 2019 ).…”