The Wnt pathway has been recognized for its crucial role in human development and homeostasis, but its dysregulation has also been linked to several disorders, including cancer. Wnt signaling is crucial for the development and metastasis of several kinds of cancer. Moreover, members of the Wnt pathway have been proven to be effective biomarkers and promising cancer therapeutic targets. Abnormal stimulation of the Wnt signaling pathway has been linked to the initiation and advancement of cancer in both clinical research and in vitro investigations. A reduction in cancer incidence rate and an improvement in survival may result from targeting the Wnt/β-catenin pathway. As a result, blocking this pathway has been the focus of cancer research, and several candidates that can be targeted are currently being developed. Flavonoids derived from plants exhibit growth inhibitory, apoptotic, anti-angiogenic, and anti-migratory effects against various malignancies. Moreover, flavonoids influence different signaling pathways, including Wnt, to exert their anticancer effects. In this review, we comprehensively evaluate the influence of flavonoids on cancer development and metastasis by focusing on the Wnt/β-catenin signaling pathway, and we provide evidence of their impact on a number of molecular targets. Overall, this review will enhance our understanding of these natural products as Wnt pathway modulators.

No abstract

Anterior cruciate ligament (ACL) injury is a common indication for Magnetic Resonance imaging examination, the advancements in Magnetic Resonance imaging have provided the considerable potential for a one-stop shop radiation-free assessment with an all-in-one modality examination of the knee joint. The aim of this study is to the evaluation of the anterior cruciate ligament injury of the knee joint using magnetic resonance imaging. A study was performed to evaluate meniscal and anterior cruciate ligament injury of the knee using MRI. A total of 92 patients were examined in this study. The data was collected from two hospitals (King Salman Specialist Hospital and King Khaled) in the Hail region in Saudi Arabia from January 2022 to July 2022. The study found that (80.4%) of patients are male patients. The highest findings were found in the age groups ranging from 21-40 years old. The most common patient compiling was found knee injuries (31.5%) and the most common findings were ACL sprain (35.9%) and ACL tore. (29.3% ) MR has shown to be very useful in ACL insufficient or deficient and can detect many ACL and Meniscal abnormalities. Our data demonstrated that ACL sprain and ACL tearing the common abnormalities . The study concluded that MRI has a high sensitivity for the detection of ACL, meniscal, and articular cartilage in patients with knee injuries, and so plays a major role in determining the disease's diagnosis and management.

Multiple sclerosis (MS) is the most common chronic inflammatory demyelinating disease of the central nervous system (CNS). MS diagnosis and disease monitoring are mostly based on Magnetic Resonance Imaging (MRI). This study aims to compare a double inversion recovery MRI sequence with a fluidattenuated inversion recovery sequence in Multiple Sclerosis (MS) in the brain. A study was conducted on 75 patients whose aged between 10 and 70 years who were having MS in the brain to compare a double inversion recovery DIR sequence with a fluid-attenuated inversion recovery FLAIR sequence at King Salman Specialist Hospital. in this study the age group (30-49) and female patient represented the highest percentage (69%) and (60%) respectively, A correlation between DIR and FLAIR in terms of the number of MS lesions and mean ±SD was found. DIR detected a higher total number of MS lesions in 75 patients tested (a total of 1886 MS lesions were detected in DIR compared to 1723 MS lesions in FLAIR). FLAIR imaging showed higher rates of periventricular lesions (a total of 508 lesions, the Mean ±SD was 9.5± 9.5) than DIR imaging (a total of 423 lesions, the Mean ± SD was 9.0± 9.0), statistically significant (p = 0.007). The DIR sequence detected a higher total number of MS lesions than the FLAIR sequence, while the FLAIR sequence is better at detecting periventricular lesions. There was no statistically significant relationship between the patient's age groups and the number of lesions in DIR and FLAIR P-value > 0.05.