Dealloying-based interpenetrating-phase nanocomposites matching the elastic behavior of human bone

Okulov, Ilya; Weißmüller, J.; Markmann, Jürgen

doi:10.1038/s41598-017-00048-4

Cited by 93 publications

(62 citation statements)

References 34 publications

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“…With the recent advancements in nanotechnology, nanocomposites offer substrates with a dimension that mimics the native ECM, improving their biocompatibility. [4][5][6][7][8] Our group is currently developing a subcutaneous implant using a nanocomposite polyurethane. 4,5 This polyurethane polymer has been extensively tested and meets international standards (ISO 10993) for biocompatibility.…”

Section: Introductionmentioning

confidence: 99%

Argon plasma improves the tissue integration and angiogenesis of subcutaneous implants by modifying surface chemistry and topography

Palgrave¹,

Medrano²,

Butler³

et al. 2018

IJN

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BackgroundTissue integration and vessel formation are important criteria for the successful implantation of synthetic biomaterials for subcutaneous implantation.ObjectiveWe report the optimization of plasma surface modification (PSM) using argon (Ar), oxygen (O2) and nitrogen (N2) gases of a polyurethane polymer to enhance tissue integration and angiogenesis.MethodsThe scaffold’s bulk and surface characteristics were compared before and after PSM with either Ar, O2 and N2. The viability and adhesion of human dermal fibroblasts (HDFs) on the modified scaffolds were compared. The formation of extracellular matrix by the HDFs on the modified scaffolds was evaluated. Scaffolds were subcutaneously implanted in a mouse model for 3 months to analyze tissue integration, angiogenesis and capsule formation.ResultsSurface analysis demonstrated that interfacial modification (chemistry, topography and wettability) achieved by PSM is unique and varies according to the gas used. O2 plasma led to extensive changes in interfacial properties, whereas Ar treatment caused moderate changes. N2 plasma caused the least effect on surface chemistry of the polymer. PSM-treated scaffolds significantly (P<0.05) enhanced HDF activity and growth over 21 days. Among all three gases, Ar modification showed the highest protein adsorption. Ar-modified scaffolds also showed a significant upregulation of adhesion-related proteins (vinculin, focal adhesion kinase, talin and paxillin; P<0.05) and extracellular matrix marker genes (collagen type I, fibronectin, laminin and elastin) and deposition of associated proteins by the HDFs. Subcutaneous implantation after 3 months demonstrated the highest tissue integration and angiogenesis and the lowest capsule formation on Ar-modified scaffolds compared with O2- and N2-modified scaffolds.ConclusionPSM using Ar is a cost-effective and efficient method to improve the tissue integration and angiogenesis of subcutaneous implants.

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Section: Introductionmentioning

confidence: 99%

Argon plasma improves the tissue integration and angiogenesis of subcutaneous implants by modifying surface chemistry and topography

Palgrave¹,

Medrano²,

Butler³

et al. 2018

IJN

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“…To synthesize the 3DNP HEA, we utilized liquid metal dealloying (LMD), a unique technique to fabricate non‐noble porous materials used in structural, functional, and medical products by preventing oxidation in a metallic melt . The high‐entropy design of LMD based on the enthalpy of mixing is depicted in Figure a,b.…”

mentioning

confidence: 99%

Beating Thermal Coarsening in Nanoporous Materials via High‐Entropy Design

et al. 2019

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produced by dealloying have outstanding physical properties due to their unique structure with open porous networks, [3][4][5] the undesirable coarsening phenomenon leads to degradation of physical properties over time, even at room temperature. [6][7][8] The originally proposed idea behind high-entropy alloy (HEA) with multiprinciple elements is maximizing the configuration entropy to stabilize a solid-solution alloy without undesired ordered intermetallics. [9][10][11] Many studies have suggested that HEAs uniquely possesses combined desirable properties such as a high strength and ductility paired with high fracture toughness, [12][13][14] fatigue resistance, [15] and creep resistance. [16] HEAs also show promising properties in harsh environments resisting corrosion, [17][18][19] and irradiation [20] attacks. Atomic size differences between constituting elements in HEA increase the activation energy for grain growth, and sluggish diffusion kinetics has considered as the main reason for the exceptional high strength and structural stability of HEAs at high temperatures. [21,22] The rationale behind it, the multiprinciple elements cause larger fluctuations in lattice potential energy (LPE), providing many low-LPE sites that hinder atomic diffusion. [23] Grain growth and ligament coarsening rely on the same physical background of surface diffusion. In that context, the high-entropy design in nanoporous materials has a potential for achieving an exceptional stability against the coarsening.Controlling the feature sizes of 3D bicontinuous nanoporous (3DNP) materials is essential for their advanced applications in catalysis, sensing, energy systems, etc., requiring high specific surface area. However, the intrinsic coarsening of nanoporous materials naturally reduces their surface energy leading to the deterioration of physical properties over time, even at ambient temperatures. A novel 3DNP material beating the universal relationship of thermal coarsening is reported via high-entropy alloy (HEA) design. In newly developed TiVNbMoTa 3DNP HEAs, the nanoporous structure is constructed by very fine nanoscale ligaments of a solid-solution phase due to enhanced phase stability by maximizing the configuration entropy and suppressed surface diffusion. The smallest size of 3DNP HEA synthesized at 873 K is about 10 nm, which is one order of magnitude smaller than that of conventional porous materials. More importantly, the yield strength of ligament in 3DNP HEA approaches its theoretical strength of G/2π of the corresponding HEA alloy even after thermal exposure. This finding signifies the key benefit of high-entropy design in nanoporous materials-exceptional stability of size-related physical properties. This high-entropy strategy should thus open new opportunities for developing ultrastable nanomaterials against its environment.The ORCID identification number(s) for the author(s) of this article can be found under https://doi.

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“…Unfortunately, many alloys form intermetallics and many metals do not easily form solid solutions, which limits the dealloying methodology. Recently, nanoporous HEAs were produced through a rather novel method [55] by using liquid metal dealloying (LMD), a technique to fabricate non-noble porous materials by suppressing oxidation in a metallic melt [56][57][58][59][60][61][62]. It turned out that the structure of nanoporous TiVNbMoTa HEAs [55] can be described as nanoscale ligaments of a solid-solution phase, the stability of which is due to suppressed surface diffusion.…”

Section: Porous/cellular Systemsmentioning

confidence: 99%

High Entropy Alloys: Ready to Set Sail?

Basu

Hosson

2020

Metals

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Over the past decade, high entropy alloys (HEAs) have transcended the frontiers of material development in terms of their unprecedented structural and functional properties compared to their counterpart conventional alloys. The possibility to explore a vast compositional space further renders this area of research extremely promising in the near future for discovering society-changing materials. The introduction of HEAs has also brought forth a paradigm shift in the existing knowledge about material design and development. It is in this regard that a fundamental understanding of the metal physics of these alloys is critical in propelling mechanism-based HEA design. The current paper highlights some of the critical viewpoints that need greater attention in the future with respect to designing mechanically and functionally advanced materials. In particular, the interplay of large compositional gradients and defect topologies in these alloys and their corresponding impact on overall mechanical response are highlighted. From the point of view of functional response, such chemistry vis-à-vis topology correlations are extended to novel class of nano-porous HEAs that beat thermal coarsening effects despite a high surface to volume ratio owing to retarded diffusion kinetics. Recommendations on material design with regards to their potential use in diverse applications such as energy storage, actuators, and as piezoelectrics are additionally considered.

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Dealloying-based interpenetrating-phase nanocomposites matching the elastic behavior of human bone

Cited by 93 publications

References 34 publications

Argon plasma improves the tissue integration and angiogenesis of subcutaneous implants by modifying surface chemistry and topography

Argon plasma improves the tissue integration and angiogenesis of subcutaneous implants by modifying surface chemistry and topography

Beating Thermal Coarsening in Nanoporous Materials via High‐Entropy Design

High Entropy Alloys: Ready to Set Sail?

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