Dealing with the Foreign‐Body Response to Implanted Biomaterials: Strategies and Applications of New Materials

Zhang, Donghui; Chen, Qi; Shi, Chao; Chen, Minzhang; Ma, Kaiqian; Wan, Jianglin; Liu, Runhui

doi:10.1002/adfm.202007226

Cited by 164 publications

(159 citation statements)

References 338 publications

(311 reference statements)

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“…We introduced porosity in the bioelectronic patch using a laser engraver technology since porosity is a well-established design parameter for implantable devices shown to reduce the inflammatory response. 40 As shown in Figures 1D and 1E, the laser engraver successfully created regular and circular pores in the patch, achieved by melting the chitosan polymer. The pore shape was maintained following the polymerization of aniline on the surface of the chitosan substrate.…”

Section: Resultsmentioning

confidence: 88%

Impact of sterilization on a conjugated polymer based bioelectronic patch

Yan

Travaglini

Lau

et al. 2021

Preprint

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Translation into the clinic of organic bioelectronic devices having conjugated polymers as the active material will hinge on their long-term operation in vivo. This will require the device to be subject to clinically approved sterilization techniques without a deterioration in its physical and electronic properties. To date, there remains a gap in the literature addressing the impact of this critical pre-operative procedure on the properties of conjugated polymers. This study aims to address this gap by assessing the physical and electronic properties of a sterilized porous bioelectronic patch having polyaniline as the conjugated polymer. The patch was sterilized by autoclave, ethylene oxide and gamma (γ-) irradiation at 15, 25, and 50 kGy doses. Autoclaving resulted in cracking and macroscopic degradation of the patch, while patches sterilized by γ-irradiation at 50 kGy exhibited reduced mechanical and electronic properties, attributed to chain scission and non-uniform crosslinking caused by the high dose irradiation. Ethylene oxide and γ-irradiation at 15 and 25 kGy sterilization appeared to be the most effective at maintaining the mechanical and electronic properties of the patch, as well as inducing a minimal immune response as revealed by a receding fibrotic capsule after 4 weeks implantation. Our findings pave the way towards closing the gap for the translation of organic bioelectronic devices from acute to long-term in vivo models.

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Section: Resultsmentioning

confidence: 88%

Impact of sterilization on a conjugated polymer based bioelectronic patch

Yan

Travaglini

Lau

et al. 2021

Preprint

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“…These shortcomings of PEG have limited its long-term in vivo application for biomaterials and biomedical devices. It is imperative to develop anti-FBR materials because materials have been the bottleneck that greatly impedes the advance in this field and the development of implantable biomaterials and medical devices 11 , 13 . Inspired by the low immunogenic silk sericin, we speculated that poly-L-serine (P-L-Ser) materials may resist the FBR.…”

Section: Introductionmentioning

confidence: 99%

“…I mplantable biomaterials and devices will be recognized by the host immune system as foreign objects to initiate a series of interactions at the implant-host interface, which leads to the foreign-body response (FBR) including strong inflammatory responses, foreign-body giant cell formation, fibrosis, and eventually collagen encapsulation around the implants and isolation of implants from the host tissue [1][2][3][4][5][6][7][8][9][10][11][12] . The FBR of implants will lead to cutting off of nutrient transportation, painful tissue deformation, and even implant failure.…”

mentioning

confidence: 99%

Bio-inspired poly-DL-serine materials resist the foreign-body response

Zhang

Chen

et al. 2021

Nat Commun

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Implantation-caused foreign-body response (FBR) is a commonly encountered issue and can result in failure of implants. The high L-serine content in low immunogenic silk sericin, and the high D-serine content as a neurotransmitter together inspire us to prepare poly-DL-serine (PSer) materials in mitigating the FBR. Here we report highly water soluble, biocompatible and easily accessible PSer hydrogels that cause negligible inflammatory response after subcutaneous implantation in mice for 1 week and 2 weeks. No obvious collagen capsulation is found surrounding the PSer hydrogels after 4 weeks, 3 months and 7 months post implantation. Histological analysis on inflammatory cytokines and RNA-seq assay both indicate that PSer hydrogels show low FBR, comparable to the Mock group. The anti-FBR performance of PSer hydrogels at all time points surpass the poly(ethyleneglycol) hydrogels that is widely utilized as bio-inert materials, implying the potent and wide application of PSer materials in implantable biomaterials and biomedical devices.

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“…In the last decades, the rise in life expectancy, traumas, tumors, and other bone diseases increased the number of orthopedic surgeries, which demand implants with good biocompatibility, mechanical and surface properties [ 1 ]. Therefore, development of new materials and techniques is necessary to obtain more durable implants with lower rejection rates [ 2 , 3 ]. Thus, regenerative medicine continues to search for new scaffolds [ 4 , 5 ], artificial organs [ 6 ], biomaterials [ 7 , 8 , 9 , 10 , 11 , 12 ] and complementary therapies [ 13 , 14 , 15 , 16 , 17 ] in order to optimize tissue regeneration [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Osseointegration Improvement of Co-Cr-Mo Alloy Produced by Additive Manufacturing

et al. 2021

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Cobalt-base alloys (Co-Cr-Mo) are widely employed in dentistry and orthopedic implants due to their biocompatibility, high mechanical strength and wear resistance. The osseointegration of implants can be improved by surface modification techniques. However, complex geometries obtained by additive manufacturing (AM) limits the efficiency of mechanical-based surface modification techniques. Therefore, plasma immersion ion implantation (PIII) is the best alternative, creating nanotopography even in complex structures. In the present study, we report the osseointegration results in three conditions of the additively manufactured Co-Cr-Mo alloy: (i) as-built, (ii) after PIII, and (iii) coated with titanium (Ti) followed by PIII. The metallic samples were designed with a solid half and a porous half to observe the bone ingrowth in different surfaces. Our results revealed that all conditions presented cortical bone formation. The titanium-coated sample exhibited the best biomechanical results, which was attributed to the higher bone ingrowth percentage with almost all medullary canals filled with neoformed bone and the pores of the implant filled and surrounded by bone ingrowth. It was concluded that the metal alloys produced for AM are biocompatible and stimulate bone neoformation, especially when the Co-28Cr-6Mo alloy with a Ti-coated surface, nanostructured and anodized by PIII is used, whose technology has been shown to increase the osseointegration capacity of this implant.

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Dealing with the Foreign‐Body Response to Implanted Biomaterials: Strategies and Applications of New Materials

Cited by 164 publications

References 338 publications

Impact of sterilization on a conjugated polymer based bioelectronic patch

Impact of sterilization on a conjugated polymer based bioelectronic patch

Bio-inspired poly-DL-serine materials resist the foreign-body response

Osseointegration Improvement of Co-Cr-Mo Alloy Produced by Additive Manufacturing

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