Bio-inspired poly-DL-serine materials resist the foreign-body response

Abstract

Implantation-caused foreign-body response (FBR) is a commonly encountered issue and can result in failure of implants. The high L-serine content in low immunogenic silk sericin, and the high D-serine content as a neurotransmitter together inspire us to prepare poly-DL-serine (PSer) materials in mitigating the FBR. Here we report highly water soluble, biocompatible and easily accessible PSer hydrogels that cause negligible inflammatory response after subcutaneous implantation in mice for 1 week and 2 weeks. No obvious collagen capsulation is found surrounding the PSer hydrogels after 4 weeks, 3 months and 7 months post implantation. Histological analysis on inflammatory cytokines and RNA-seq assay both indicate that PSer hydrogels show low FBR, comparable to the Mock group. The anti-FBR performance of PSer hydrogels at all time points surpass the poly(ethyleneglycol) hydrogels that is widely utilized as bio-inert materials, implying the potent and wide application of PSer materials in implantable biomaterials and biomedical devices.

Dynamic actuation enhances transport and extends therapeutic lifespan in an implantable drug delivery platform

“…Conventional strategies to mitigate the FBR have focused on changing the attributes of the implant material itself, such as its size, shape, topography and surface coating [20][21][22][23][24][25][26][27][28] , or involved the concomitant delivery of FBR modifying drugs, such as steroidal antiinflammatory, anti-fibrotic, and anti-proliferative agents 29 . While these strategies have shown promise, they have not succeeded in completely disarming the FBR and possess several limitations.…”

Preparation and characterisation of tough and porous polyvinyl alcohol/POC membrane for biomedical applications

“…Given the complex environment and the fact that the foreign body response is a highly sophisticated event involving various types of cells and stages, it would be more insightful to provide information to determine how material physiochemical properties impact host response once biomaterials are implanted [29,30]. Therefore, PVA, PP, and CPP fibrous membranes were subcutaneously implanted in a rat model, and the inflammatory response was thoroughly investigated.…”

Melamine Barbiturate as a Light-Induced Nanostructured Supramolecular Material for a Bioinspired Oxygen and Organic Radical Trap and Stabilization

“…Bioinspired material design has been a great trend in tissue engineering for at least a decade. − One crucial aspect of tissue engineering is oxygen delivery or production that requires novel derivatives of previously known functional materials . Several metal–organic frameworks are considered to trap oxygen due to their high porosity and specific surface area. − Some layered perovskites show the same function but without oxygen release. , Bioinspired materials that mimic biological systems’ functions or composition release oxygen under mild conditions, which is a great advantage of these materials …”